LSM2 - LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated Gene

中文名称：LSM2 同系物、U6 小核 RNA 和 mRNA 降解相关

种属: Homo sapiens

同用名: G7B; snRNP; C6orf28; YBL026W

基因 ID: 57819 | 基因类型: protein coding

关于 LSM2

Cytogenetic location: 6p21.33 Genomic coordinates (GRCh38): 6:31,797,396-31,806,966 (from NCBI)

This gene has 7 transcripts (splice variants), 1 gene allele and 188 orthologues. Ubiquitous expression in lymph node (RPKM 15.9), appendix (RPKM 13.7) and 25 other tissues.

功能概要

该基因编码 RNA 结合蛋白 LSm 家族的成员。 LSm 蛋白形成稳定的异聚体，特异性结合 U6 snRNA 的 3'-末端寡核苷酸 (U) 束，并可能通过介导 U4/U6 snRNP 形成在 pre-mRNA 剪接中发挥作用。该基因的假基因位于 6 号和 19 号染色体的短臂上。[RefSeq 提供，2011 年 11 月]

This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Pseudogenes of this gene are located on the short arm of chromosomes 6 and 19. [provided by RefSeq, Nov 2011]

LSM2 基因产物(1)

mRNA	Protein	Name
NM_021177.5	NP_067000.1	U6 snRNA-associated Sm-like protein LSm2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	14667819	GOA
enables small GTPase binding	IPI IPI: 通过物理相互作用推断	24056301	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
acts upstream of or within mRNA catabolic process	IDA IDA: 通过直接分析推断	12515382	GOA
involved in mRNA splicing, via spliceosome	IDA IDA: 通过直接分析推断	28781166	GOA
acts upstream of or within spliceosomal tri-snRNP complex assembly	IDA IDA: 通过直接分析推断	10523320	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of Lsm2-8 complex	IDA IDA: 通过直接分析推断	10523320	GOA
part of U2-type precatalytic spliceosome	IDA IDA: 通过直接分析推断	28781166	GOA
part of U4/U6 x U5 tri-snRNP complex	IDA IDA: 通过直接分析推断	10523320	GOA
part of U4/U6 x U5 tri-snRNP complex	IPI IPI: 通过物理相互作用推断	30975767	GOA
part of catalytic step 2 spliceosome	IDA IDA: 通过直接分析推断	11991638	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	12515382	GOA
located in nucleus	IDA IDA: 通过直接分析推断	10523320	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

LSM2 蛋白结构

LSM

0
95 a.a.

蛋白主名

其他名称

U6 snRNA-associated Sm-like protein LSm2

LSM2 U6 small nuclear RNA and mRNA degradation associated

LSM2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	LSM2	Q9Y333	KRT13	Homo sapiens	A1A4E9	Y2H Prey Pooling	25416956
种属内	LSM2	Q9Y333	KRT13	Homo sapiens	A1A4E9	Validated Y2H	25416956
种属内	LSM2	Q9Y333	MAGEA6	Homo sapiens	P43360	Y2H Array	32296183
种属内	LSM2	Q9Y333	MAGEA6	Homo sapiens	P43360	Y2H Prey Pooling	25416956
种属内	LSM2	Q9Y333	MAGEA6	Homo sapiens	P43360	Validated Y2H	25416956
种属内	LSM2	Q9Y333	MAGEA6	Homo sapiens	P43360	Y2H Prey Pooling	32296183
种属内	LSM2	Q9Y333	LZTS1	Homo sapiens	Q9Y250	Y2H Array	32296183
种属内	LSM2	Q9Y333	LZTS1	Homo sapiens	Q9Y250	Y2H Prey Pooling	32296183
种属内	LSM2	Q9Y333	TRIM54	Homo sapiens	Q9BYV2	Y2H Array	25416956
种属内	LSM2	Q9Y333	SNRPD2	Homo sapiens	P62316	Y2H	15231747
种属内	LSM2	Q9Y333	SNRPD2	Homo sapiens	P62316	Y2H	22365833
种属内	LSM2	Q9Y333	SNRPD2	Homo sapiens	P62316	Y2H	14667819
种属内	LSM2	Q9Y333	REL	Homo sapiens	Q04864	Y2H Prey Pooling	25416956
种属内	LSM2	Q9Y333	LSM1	Homo sapiens	O15116	Y2H Prey Pooling	32296183
种属内	LSM2	Q9Y333	LSM1	Homo sapiens	O15116	Y2H	15231747
种属内	LSM2	Q9Y333	LSM1	Homo sapiens	O15116	Y2H Array	32296183
种属内	LSM2	Q9Y333	ZNF408	Homo sapiens	Q9H9D4	Y2H	14667819
种属内	LSM2	Q9Y333	ZNF408	Homo sapiens	Q9H9D4	Y2H	15231747
种属内	LSM2	Q9Y333	LSM8	Homo sapiens	O95777	GMS	19628699
种属内	LSM2	Q9Y333	LSM8	Homo sapiens	O95777	Y2H	22365833
种属内	LSM2	Q9Y333	LSM8	Homo sapiens	O95777	Y2H	14667819
种属内	LSM2	Q9Y333	LSM8	Homo sapiens	O95777	Y2H	15231747
种属内	LSM2	Q9Y333	LSM8	Homo sapiens	O95777	Ion Exchange Chrom	19628699
种属内	LSM2	Q9Y333	SNRPE	Homo sapiens	P62304	Y2H	14667819
种属内	LSM2	Q9Y333	SNRPE	Homo sapiens	P62304	Y2H	15231747
种属内	LSM2	Q9Y333	LSM3	Homo sapiens	P62310	Y2H Pooling	16169070
种属内	LSM2	Q9Y333	LSM3	Homo sapiens	P62310	GMS	19628699
种属内	LSM2	Q9Y333	LSM3	Homo sapiens	P62310	Y2H	21516116
种属内	LSM2	Q9Y333	LSM3	Homo sapiens	P62310	Lumier	37398436
种属内	LSM2	Q9Y333	LSM3	Homo sapiens	P62310	Y2H Prey Pooling	25416956
种属内	LSM2	Q9Y333	LSM3	Homo sapiens	P62310	Y2H Array	31467278
种属内	LSM2	Q9Y333	LSM3	Homo sapiens	P62310	Ion Exchange Chrom	19628699
种属内	LSM2	Q9Y333	LSM3	Homo sapiens	P62310	Y2H Array	25416956
种属内	LSM2	Q9Y333	LSM3	Homo sapiens	P62310	SLC	31467278
种属内	LSM2	Q9Y333	LSM3	Homo sapiens	P62310	SLC	27107012
种属内	LSM2	Q9Y333	LSM3	Homo sapiens	P62310	Y2H	14667819
种属内	LSM2	Q9Y333	LSM3	Homo sapiens	P62310	Y2H	15231747
种属内	LSM2	Q9Y333	LSM3	Homo sapiens	P62310	BRET	37398436
种属内	LSM2	Q9Y333	LSM3	Homo sapiens	P62310	BFG-2H	27107012
种属内	LSM2	Q9Y333	LSM3	Homo sapiens	P62310	Y2H Array	32296183
种属内	LSM2	Q9Y333	LSM7	Homo sapiens	Q9UK45	Y2H	22365833
种属内	LSM2	Q9Y333	LSM7	Homo sapiens	Q9UK45	Y2H	14667819
种属内	LSM2	Q9Y333	LSM7	Homo sapiens	Q9UK45	Y2H Prey Pooling	32296183
种属内	LSM2	Q9Y333	LSM7	Homo sapiens	Q9UK45	Ion Exchange Chrom	19628699
种属内	LSM2	Q9Y333	LSM7	Homo sapiens	Q9UK45	Y2H	15231747
种属内	LSM2	Q9Y333	LSM7	Homo sapiens	Q9UK45	GMS	19628699
种属内	LSM2	Q9Y333	LSM7	Homo sapiens	Q9UK45	Y2H Array	32296183
种属内	LSM2	Q9Y333	SNRPB	Homo sapiens	P14678-2	Y2H Prey Pooling	32296183
种属内	LSM2	Q9Y333	SNRPB	Homo sapiens	P14678-2	Y2H Array	32296183
种属内	LSM2	Q9Y333	LSM6	Homo sapiens	P62312	Y2H Prey Pooling	32296183
种属内	LSM2	Q9Y333	LSM6	Homo sapiens	P62312	Ion Exchange Chrom	19628699
种属内	LSM2	Q9Y333	LSM6	Homo sapiens	P62312	GMS	19628699
种属内	LSM2	Q9Y333	LSM6	Homo sapiens	P62312	Y2H Array	32296183
种属内	LSM2	Q9Y333	LSM6	Homo sapiens	P62312	Y2H	22365833
种属内	LSM2	Q9Y333	MAGEA3	Homo sapiens	P43357	Y2H Array	32296183
种属内	LSM2	Q9Y333	MAGEA3	Homo sapiens	P43357	Y2H Prey Pooling	32296183
种属内	LSM2	Q9Y333	TLE5	Homo sapiens	Q08117	Validated Y2H	25416956
种属内	LSM2	Q9Y333	TLE5	Homo sapiens	Q08117	Y2H Prey Pooling	25416956
种属内	LSM2	Q9Y333	CLNS1A	Homo sapiens	P54105	Y2H	22365833
种属内	LSM2	Q9Y333	CLNS1A	Homo sapiens	P54105	Y2H Array	25416956
种属内	LSM2	Q9Y333	CLNS1A	Homo sapiens	P54105	Y2H Array	32296183
种属内	LSM2	Q9Y333	CLNS1A	Homo sapiens	P54105	Y2H Prey Pooling	25416956
种属内	LSM2	Q9Y333	CLNS1A	Homo sapiens	P54105	Validated Y2H	25416956
种属内	LSM2	Q9Y333	CLNS1A	Homo sapiens	P54105	Y2H Prey Pooling	32296183
种属内	LSM2	Q9Y333	LSM12	Homo sapiens	Q3MHD2	Y2H Prey Pooling	32296183
种属内	LSM2	Q9Y333	LSM12	Homo sapiens	Q3MHD2	Y2H Array	32296183
种属内	LSM2	Q9Y333	LNX1	Homo sapiens	Q8TBB1	Y2H Prey Pooling	25416956
种属内	LSM2	Q9Y333	LNX1	Homo sapiens	Q8TBB1	Validated Y2H	25416956
种属内	LSM2	Q9Y333	DNAAF11	Homo sapiens	Q86X45	Y2H Prey Pooling	32296183
种属内	LSM2	Q9Y333	DNAAF11	Homo sapiens	Q86X45	Y2H Array	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Mixed Connective Tissue Disease

Sharp Syndrome	Mctd
Connective Tissue Disease Overlap Syndrome	Mixed Collagen Vascular Disease
Mctd - [Mixed Connective Tissue Disease]

Spinal Muscular Atrophy

Sma	5q Sma
Proximal Sma	Sma-Associated Sma
Spinal Amyotrophies	Spinal Amyotrophy
Spinal Muscle Degeneration	Spinal Muscle Wasting
Muscular Atrophy Spinal	Atrophy, Muscular, Spinal
Hereditary Motor Neuronopathy	Progressive Muscular Atrophy
Sma - [Spinal Muscular Atrophy]

Cystic Echinococcosis

Echinococcus Granulosus Infection	Echinococcus Granulosus Infection Of Lung
Echinococcus Granulosus	Echinococcus Granulosus Infection Of Thyroid
Echinococcus Granulosus Infectious Disease	Echinococcus Granulosus Infectious Disease Of Liver
Echinococcus Granulosus Infectious Disease Of Thyroid	Liver Echinococcus Granulosus
Lung Echinococcus Granulosus	Thyroid Echinococcus Granulosus
Unilocular Echinococcosis	Unilocular Hydatid Disease
Hydatid Disease	Hydatidosis
Echinococcosis

Connective Tissue Disease

Connective Tissue Diseases	Connective Tissue Disorder
Abnormality Of Connective Tissue	Disorder Of Connective Tissue
Connective Tissue Disorders

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS07857	LSM2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	LSM2	VGNC	VGNC:81088
Bos taurus	LSM2	VGNC	VGNC:31054
Felis catus	LSM2	VGNC	VGNC:102452
Rattus norvegicus	LSM2	RGD	RGD:1598536
Mus musculus	LSM2	MGD	MGI:90676

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

LSM2 - LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated Gene

关于 LSM2

功能概要

LSM2 基因产物(1)

LSM2 蛋白结构

LSM2 蛋白互作信息

关联疾病

直系同源

热门区域

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LSM2 - LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated Gene

关于 LSM2

功能概要

LSM2 基因产物(1)

LSM2 蛋白结构

LSM2 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

N

Q

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