SNRPE - small nuclear ribonucleoprotein polypeptide E Gene

中文名称：小核核糖核蛋白多肽 E

种属: Homo sapiens

同用名: SME; Sm-E; HYPT11; snRNP-E

基因 ID: 6635 | 基因类型: protein coding

关于 SNRPE

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:203,861,599-203,871,152 (from NCBI)

This gene has 6 transcripts (splice variants), 178 orthologues and is associated with 3 phenotypes. Ubiquitous expression in colon (RPKM 16.8), ovary (RPKM 16.5) and 25 other tissues.

功能概要

该基因编码的蛋白质是 U 小核核糖核蛋白的核心成分，是 pre-mRNA 加工剪接体的关键成分。编码的蛋白质在组蛋白转录物的 3' 端加工中发挥作用。这种蛋白质是自身免疫性疾病系统性红斑狼疮的靶标之一，该基因的突变与少毛症有关。已经鉴定了该基因的几个假基因。[RefSeq 提供，2016 年 6 月]

The protein encoded by this gene is a core component of U small nuclear ribonucleoproteins, which are key components of the pre-mRNA processing spliceosome. The encoded protein plays a role in the 3' end processing of histone transcripts. This protein is one of the targets in the autoimmune disease systemic lupus erythematosus, and mutations in this gene have been associated with hypotrichosis. Several pseudogenes of this gene have been identified. [provided by RefSeq, Jun 2016]

SNRPE 基因产物(4)

mRNA	Protein	Name
NM_001304464.2	NP_001291393.1	small nuclear ribonucleoprotein E isoform 2
NM_001328637.2	NP_001315566.1	small nuclear ribonucleoprotein E isoform 3
NM_001328638.2	NP_001315567.1	small nuclear ribonucleoprotein E isoform 4
NM_003094.4	NP_003085.1	small nuclear ribonucleoprotein E isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	9417867	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in mRNA splicing, via spliceosome	IDA IDA: 通过直接分析推断	28076346	GOA
involved in spliceosomal snRNP assembly	IDA IDA: 通过直接分析推断	18984161	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of SMN-Sm protein complex	IDA IDA: 通过直接分析推断	18984161	GOA
part of U1 snRNP	IDA IDA: 通过直接分析推断	21113136	GOA
part of U1 snRNP	IPI IPI: 通过物理相互作用推断	33677607	GOA
part of U12-type spliceosomal complex	IDA IDA: 通过直接分析推断	15146077	GOA
part of U2-type catalytic step 2 spliceosome	IDA IDA: 通过直接分析推断	28076346	GOA
part of U2-type precatalytic spliceosome	IDA IDA: 通过直接分析推断	28781166	GOA
part of U2-type spliceosomal complex	IDA IDA: 通过直接分析推断	32494006	GOA
part of U4 snRNP	IDA IDA: 通过直接分析推断	21516107	GOA
part of U4/U6 x U5 tri-snRNP complex	IDA IDA: 通过直接分析推断	26912367	GOA
part of U4/U6 x U5 tri-snRNP complex	IPI IPI: 通过物理相互作用推断	30975767	GOA
part of U7 snRNP	IDA IDA: 通过直接分析推断	11574479	GOA
part of catalytic step 2 spliceosome	IDA IDA: 通过直接分析推断	11991638	GOA
located in cytosol	IDA IDA: 通过直接分析推断	18984161	GOA
part of methylosome	IDA IDA: 通过直接分析推断	18984161	GOA
located in nucleus	IDA IDA: 通过直接分析推断	23246290	GOA
part of pICln-Sm protein complex	IDA IDA: 通过直接分析推断	18984161	GOA
part of spliceosomal complex	IPI IPI: 通过物理相互作用推断	33677607	GOA
part of telomerase holoenzyme complex	IDA IDA: 通过直接分析推断	18082603	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SNRPE 蛋白结构

LSM

0
92 a.a.

蛋白主名

其他名称

small nuclear ribonucleoprotein E

sm protein E

SNRPE 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	SNRPE	P62304	SF3A2	Homo sapiens	Q15428	Anti Tag CoIP	33961781
Intra	SNRPE	P62304	SF3A2	Homo sapiens	Q15428	Anti Tag CoIP	28514442
Intra	SNRPE	P62304	LSM2	Homo sapiens	Q9Y333	Anti Tag CoIP	28514442
Intra	SNRPE	P62304	LSM2	Homo sapiens	Q9Y333	Anti Tag CoIP	33961781
Intra	SNRPE	P62304	SNRPF	Homo sapiens	P62306	Validated Y2H	32296183
Intra	SNRPE	P62304	SNRPF	Homo sapiens	P62306	Anti Tag CoIP	33961781
Intra	SNRPE	P62304	SNRPF	Homo sapiens	P62306	Y2H Array	32296183
Intra	SNRPE	P62304	SNRPF	Homo sapiens	P62306	Anti Tag CoIP	28514442
Intra	SNRPE	P62304	SNRPF	Homo sapiens	P62306	Comig Non-Denat Gel	18984161
Intra	SNRPE	P62304	SNRPF	Homo sapiens	P62306	Y2H	9417867
Intra	SNRPE	P62304	SNRPF	Homo sapiens	P62306	Y2H Prey Pooling	32296183
Intra	SNRPE	P62304	SNRPF	Homo sapiens	P62306	Y2H	22365833
Intra	SNRPE	P62304	SNRPF	Homo sapiens	P62306	GMS	18984161
Intra	SNRPE	P62304	LSM5	Homo sapiens	Q9Y4Y9	Validated Y2H	32296183
Intra	SNRPE	P62304	LSM5	Homo sapiens	Q9Y4Y9	Anti Tag CoIP	33961781
Intra	SNRPE	P62304	GEMIN5	Homo sapiens	Q8TEQ6	Anti Tag CoIP	28514442
Intra	SNRPE	P62304	GEMIN5	Homo sapiens	Q8TEQ6	Anti Tag CoIP	33961781
Intra	SNRPE	P62304	SNRPG	Homo sapiens	P62308	Anti Tag CoIP	33961781
Intra	SNRPE	P62304	SNRPG	Homo sapiens	P62308	Validated Y2H	32296183
Intra	SNRPE	P62304	SNRPG	Homo sapiens	P62308	GMS	18984161
Intra	SNRPE	P62304	SNRPG	Homo sapiens	P62308	Comig Non-Denat Gel	18984161
Intra	SNRPE	P62304	SNRPG	Homo sapiens	P62308	Y2H	9417867
Intra	SNRPE	P62304	GEMIN6	Homo sapiens	Q8WXD5	Anti Tag CoIP	33961781
Intra	SNRPE	P62304	GEMIN6	Homo sapiens	Q8WXD5	Anti Tag CoIP	28514442

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Hypotrichosis 11

HYPT11

Hypotrichosis, Type 11

Hypotrichosis Simplex

Hereditary Hypotrichosis Simplex

Hhs

Hypotrichosis

Hypotrichosis 7

Woolly Hair, Autosomal Recessive 2, With Or Without Hypotrichosis	HYPT7
Hypotrichosis, Localized, Autosomal Recessive 2	Lah2
Ah	Total Hypotrichosis, Mari Type
Wh/Ht	Hypotrichosis, Autosomal Recessive
Hypotrichosis, Total, Mari Type	Woolly Hair, Autosomal Recessive 2 With Or Without Hypotrichosis
Total Mari Type Hypotrichosis	Alopecia Universalis Congenita, Mari Type
Mari Type Alopecia Universalis Congenita	Autosomal Recessive Hypotrichosis
Autosomal Recessive Localized Hypotrichosis	Autosomal Recessive Woolly Hair With Or Without Hypotrichosis
Htl	Hypotrichoses
Hypotrichosis	Lah
Alopecia Universalis Congenita Mari Type	Hypotrichosis Autosomal Recessive
Hypotrichosis Localized Autosomal Recessive 2	Total Hypotrichosis Mari Type
Woolly Hair Autosomal Recessive 2	ARWH2
Woolly Hair Autosomal Recessive 2 With Or Without Hypotrichosis

Lupus Erythematosus

Lupus	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus, Systemic
Subacute Cutaneous Lupus	Le - [Lupus Erythematosus]

Hypotrichosis 4

HYPT4	Marie Unna Hereditary Hypotrichosis 1
Muhh1	Hypotrichosis, Marie Unna Type, 1
Hypotrichosis Marie Unna 1	Marie Unna Hereditary Hypotrichosis Type 1
Hypotrichosis, Hereditary, Marie Unna Type, 1	Hypotrichosis, Type 4

Hypotrichosis 6

HYPT6	Lah1
Hypotrichosis, Localized, Autosomal Recessive	Monilethrix-Like Hypotrichosis
Hypotrichosis, Localized, Autosomal Recessive 1	Lah
Htl	Autosomal Recessive Localized Hypotrichosis
Hypotrichosis Localized Autosomal Recessive	Hypotrichosis Localized Autosomal Recessive 1
Hypotrichosis, Type 6

Hypotrichosis 8

HYPT8	Lah3
Hypotrichosis, Localized, Autosomal Recessive 3	Woolly Hair, Autosomal Recessive 1, With Or Without Hypotrichosis
Autosomal Recessive Woolly Hair 1, With Or Without Hypotrichosis	Hypotrichosis Localized Autosomal Recessive 3
Woolly Hair Autosomal Recessive 1 With Or Without Hypotrichosis	ARWH1
Hypotrichosis, Type 8

Hypotrichosis 13

HYPT13	Hypotrichosis With Woolly Hair
Hypotrichosis, Type 13

Muscular Atrophy

Muscle Wasting	Amyotrophia
Wasting - Muscle	Skeletal Muscle Atrophy

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Spinal Muscular Atrophy

Sma	5q Sma
Proximal Sma	Sma-Associated Sma
Spinal Amyotrophies	Spinal Amyotrophy
Spinal Muscle Degeneration	Spinal Muscle Wasting
Muscular Atrophy Spinal	Atrophy, Muscular, Spinal
Hereditary Motor Neuronopathy	Progressive Muscular Atrophy
Sma - [Spinal Muscular Atrophy]

Alopecia, Neurologic Defects, And Endocrinopathy Syndrome

Ane Syndrome	ANES
Alopecia-Progressive Neurological Defect-Endocrinopathy Syndrome	Alopecia-Progressive Neurological Defect-Endocrinopathy
Endocrine System Diseases

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS13508	SNRPE Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	SNRPE	MGD	MGI:98346
Rattus norvegicus	SNRPE	RGD	RGD:2321675
Macaca mulatta	SNRPE	VGNC	VGNC:100145

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

SNRPE - small nuclear ribonucleoprotein polypeptide E Gene

关于 SNRPE

功能概要

SNRPE 基因产物(4)

SNRPE 蛋白结构

SNRPE 蛋白互作信息

关联疾病

直系同源

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SNRPE - small nuclear ribonucleoprotein polypeptide E Gene

关于 SNRPE

功能概要

SNRPE 基因产物(4)

SNRPE 蛋白结构

SNRPE 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z