SF3A2 - splicing factor 3a subunit 2 Gene

中文名称：剪接因子 3a 亚基 2

种属: Homo sapiens

同用名: PRP11; SAP62; PRPF11; SF3a66

关于 SF3A2

功能概要

该基因编码剪接因子 3a 蛋白复合物的第 2 亚基。剪接因子 3a 异源三聚体包括亚基 1、2 和 3，并且是将 15S U2 snRNP 体外转化为活性 17S 颗粒以执行 pre-mRNA 剪接所必需的。亚基 2 通过其氨基末端与亚基 1 相互作用，而亚基 2 的单个锌指结构域在其与 15S U2 snRNP 的结合中发挥作用。亚基 2 也可以独立于其 RNA 剪接功能作为微管结合蛋白发挥作用。[RefSeq 提供，2008 年 7 月]

This gene encodes subunit 2 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 2 interacts with subunit 1 through its amino-terminus while the single zinc finger domain of subunit 2 plays a role in its binding to the 15S U2 snRNP. Subunit 2 may also function independently of its RNA splicing function as a microtubule-binding protein. [provided by RefSeq, Jul 2008]