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  2. DHX15 - DEAH-box helicase 15 Gene

DHX15 - DEAH-box helicase 15 Gene

中文名称:DEAH 盒解旋酶 15

种属: Homo sapiens

同用名: DBP1; DDX15; PRP43; PRPF43; hPrp43; PrPp43p

基因 ID: 1665 | 基因类型: protein coding

关于 DHX15

Cytogenetic location: 4p15.2 Genomic coordinates (GRCh38): 4:24,527,475-24,584,554 (from NCBI)

This gene has 10 transcripts (splice variants), 271 orthologues and 18 paralogues. Ubiquitous expression in bone marrow (RPKM 42.0), lymph node (RPKM 36.6) and 25 other tissues.

功能概要

由该基因编码的蛋白质是一种推定的 ATP 依赖性 RNA 解旋酶,与 pre-mRNA 剪接有关。[RefSeq 提供,2008 年 7 月]

The protein encoded by this gene is a putative ATP-dependent RNA helicase implicated in pre-mRNA splicing. [provided by RefSeq, Jul 2008]

DHX15 基因产物(1)

mRNA Protein Name
NM_001358.3 NP_001349.2 ATP-dependent RNA helicase DHX15
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables RNA binding IDA
IDA: 通过直接分析推断
32179686 GOA
enables RNA helicase activity IDA
IDA: 通过直接分析推断
32179686 GOA
enables double-stranded RNA binding IDA
IDA: 通过直接分析推断
21266579 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
17332742 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in antiviral innate immune response IDA
IDA: 通过直接分析推断
24990078 GOA
involved in defense response to virus IDA
IDA: 通过直接分析推断
24990078 GOA
involved in positive regulation of canonical NF-kappaB signal transduction IDA
IDA: 通过直接分析推断
24990078 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of U12-type spliceosomal complex IDA
IDA: 通过直接分析推断
15146077 GOA
part of U2-type post-mRNA release spliceosomal complex IDA
IDA: 通过直接分析推断
19103666 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

DHX15 蛋白结构

DEAD

DEAD: DEAD/DEAH box helicase (148 - 296)

Helicase_C

Helicase_C: Helicase conserved C-terminal domain (382 - 476)

HA2

HA2: Helicase associated domain (HA2) (539 - 628)

OB_NTP_bind

OB_NTP_bind: Oligonucleotide/oligosaccharide-binding (OB)-fold (662 - 765)

  • 0
  • 200
  • 400
  • 600
  • 795 a.a.
蛋白主名 其他名称

ATP-dependent RNA helicase DHX15

ATP-dependent RNA helicase #46

DHX15 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra DHX15 O43143 ZGPAT Homo sapiens Q8N5A5-2
Y2H Prey Pooling
25416956
Intra DHX15 O43143 ZGPAT Homo sapiens Q8N5A5-2
Validated Y2H
25416956
Intra DHX15 O43143 ZGPAT Homo sapiens Q8N5A5-2
Y2H Prey Pooling
32296183
Intra DHX15 O43143 ZGPAT Homo sapiens Q8N5A5-2
Validated Y2H
32296183
Intra DHX15 O43143 ZGPAT Homo sapiens Q8N5A5-2
Y2H Array
25416956
Intra DHX15 O43143 ZGPAT Homo sapiens Q8N5A5-2
Y2H Array
32296183
Intra DHX15 O43143 FXR1 Homo sapiens P51114-2
Y2H Prey Pooling
32296183
Intra DHX15 O43143 FXR1 Homo sapiens P51114-2
Y2H Array
32296183
Intra DHX15 O43143 FXR1 Homo sapiens P51114-2
Validated Y2H
32296183
Intra DHX15 O43143 CAMSAP3 Homo sapiens Q9P1Y5-2
Validated Y2H
32296183
Intra DHX15 O43143 CAMSAP3 Homo sapiens Q9P1Y5-2
Y2H Prey Pooling
32296183
Intra DHX15 O43143 CAMSAP3 Homo sapiens Q9P1Y5-2
Y2H Array
32296183
Intra DHX15 O43143 NUDCD1 Homo sapiens Q96RS6-1
Anti Tag CoIP
29021621
Intra DHX15 O43143 SF3A2 Homo sapiens Q15428
Anti Tag CoIP
24304693
Intra DHX15 O43143 SUGP1 Homo sapiens Q8IWZ8
Y2H
22365833
Intra DHX15 O43143 KRT75 Homo sapiens O95678
Validated Y2H
32296183
Intra DHX15 O43143 KRT75 Homo sapiens O95678
Y2H Prey Pooling
32296183
Intra DHX15 O43143 KRT75 Homo sapiens O95678
Y2H Array
32296183
Intra DHX15 O43143 ZGPAT Homo sapiens Q8N5A5
Y2H Prey Pooling
25416956
Intra DHX15 O43143 ZGPAT Homo sapiens Q8N5A5
Y2H Array
25416956
Intra DHX15 O43143 RBM5 Homo sapiens P52756
Y2H
22569250
Intra DHX15 O43143 RBM5 Homo sapiens P52756
Anti Tag CoIP
22569250
Intra DHX15 O43143 RBM5 Homo sapiens P52756
Y2H
22365833
Intra DHX15 O43143 RBM5 Homo sapiens P52756
Anti Tag CoIP
22365833
Intra DHX15 O43143 RBM5 Homo sapiens P52756
Anti Tag CoIP
24304693
Intra DHX15 O43143 RBM10 Homo sapiens P98175
Anti Tag CoIP
29021621
Intra DHX15 O43143 RBM17 Homo sapiens Q96I25
Y2H Array
32296183
Intra DHX15 O43143 RBM17 Homo sapiens Q96I25
Anti Tag CoIP
22365833
Intra DHX15 O43143 RBM17 Homo sapiens Q96I25
Anti Tag CoIP
29021621
Intra DHX15 O43143 RBM17 Homo sapiens Q96I25
Y2H Prey Pooling
32296183
Intra DHX15 O43143 RBM17 Homo sapiens Q96I25
Y2H
22365833
Intra DHX15 O43143 RBM17 Homo sapiens Q96I25
Y2H Prey Pooling
25416956
Intra DHX15 O43143 RBM17 Homo sapiens Q96I25
Validated Y2H
32296183
Intra DHX15 O43143 AGGF1 Homo sapiens Q8N302
Y2H Array
32296183
Intra DHX15 O43143 AGGF1 Homo sapiens Q8N302
Validated Y2H
32296183
Intra DHX15 O43143 AGGF1 Homo sapiens Q8N302
Y2H Prey Pooling
32296183
Intra DHX15 O43143 GPANK1 Homo sapiens O95872
Validated Y2H
32296183
Intra DHX15 O43143 NKRF Homo sapiens O15226
Anti Tag CoIP
29021621
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
X-Linked Intellectual Disability-Short Stature-Overweight Syndrome

Mrx12

Mrx35

X-Linked Mental Retardation 12

X-Linked Mental Retardation 35

Posterior Cerebral Artery Infarction

Infarction, Posterior Cerebral Artery

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus DHX15 RGD RGD:1308072
Mus musculus DHX15 MGD MGI:1099786
Felis catus DHX15 VGNC VGNC:61474
Canis familiaris DHX15 VGNC VGNC:39939
Bos taurus DHX15 VGNC VGNC:28048
Macaca mulatta DHX15 VGNC VGNC:71760