ZGPAT - zinc finger CCCH-type and G-patch domain containing Gene

中文名称：含锌指 CCCH 型和 G 补丁域

种属: Homo sapiens

同用名: ZIP; ZC3H9; GPATC6; GPATCH6; ZC3HDC9; KIAA1847

基因 ID: 84619 | 基因类型: protein coding

关于 ZGPAT

Cytogenetic location: 20q13.33 Genomic coordinates (GRCh38): 20:63,707,442-63,736,142 (from NCBI)

This gene has 11 transcripts (splice variants), 199 orthologues and 2 paralogues. Ubiquitous expression in liver (RPKM 22.1), kidney (RPKM 17.5) and 25 other tissues.

功能概要

启用 DNA 结合转录抑制活性、RNA 聚合酶 II 特异性和 RNA 聚合酶 II 顺式调控区域序列特异性 DNA 结合活性。参与表皮生长因子激活受体活性的负调节和 RNA 聚合酶 II 转录的负调节。位于核质和质膜中。 [由基因组资源联盟提供，2022 年 4 月]

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of epidermal growth factor-activated receptor activity and negative regulation of transcription by RNA polymerase II. Located in nucleoplasm and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

ZGPAT 基因产物(5)

mRNA	Protein	Name
NM_001083113.2	NP_001076582.1	zinc finger CCCH-type with G patch domain-containing protein isoform c
NM_001195653.2	NP_001182582.1	zinc finger CCCH-type with G patch domain-containing protein isoform c
NM_001195654.2	NP_001182583.1	zinc finger CCCH-type with G patch domain-containing protein isoform d
NM_032527.5	NP_115916.3	zinc finger CCCH-type with G patch domain-containing protein isoform a
NM_181485.3	NP_852150.2	zinc finger CCCH-type with G patch domain-containing protein isoform c

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables DNA-binding transcription factor activity	IDA IDA: 通过直接分析推断	19644445	GOA
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: 通过直接分析推断	19644445	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: 通过直接分析推断	19644445	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	19644445	GOA
enables sequence-specific DNA binding	IDA IDA: 通过直接分析推断	19644445	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	19644445	GOA
involved in negative regulation of epidermal growth factor-activated receptor activity	IDA IDA: 通过直接分析推断	19644445	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	19644445	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in nucleus	IDA IDA: 通过直接分析推断	19644445	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ZGPAT 蛋白结构

G-patch

0
100
200
300
400
500
531 a.a.

蛋白主名

其他名称

zinc finger CCCH-type with G patch domain-containing protein

g patch domain-containing protein 6

ZGPAT 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	ZGPAT	Q8N5A5	KRT40	Homo sapiens	Q6A162	Y2H Prey Pooling	25416956
种属内	ZGPAT	Q8N5A5	MID2	Homo sapiens	Q9UJV3-2	Y2H Array	25416956
种属内	ZGPAT	Q8N5A5	TP53BP2	Homo sapiens	Q13625-3	Y2H Array	25416956
种属内	ZGPAT	Q8N5A5	TP53BP2	Homo sapiens	Q13625-3	Validated Y2H	25416956
种属内	ZGPAT	Q8N5A5	FAM9B	Homo sapiens	Q8IZU0	Y2H Prey Pooling	25416956
种属内	ZGPAT	Q8N5A5	AMOTL2	Homo sapiens	Q9Y2J4-4	Y2H Array	25416956
种属内	ZGPAT	Q8N5A5	AMOTL2	Homo sapiens	Q9Y2J4-4	Y2H Prey Pooling	25416956
种属内	ZGPAT	Q8N5A5	TFIP11	Homo sapiens	Q9UBB9	Y2H Array	31515488
种属内	ZGPAT	Q8N5A5	TFIP11	Homo sapiens	Q9UBB9	Y2H Array	25416956
种属内	ZGPAT	Q8N5A5	DHX15	Homo sapiens	O43143	Y2H Array	25416956
种属内	ZGPAT	Q8N5A5	DHX15	Homo sapiens	O43143	Anti Tag CoIP	19644445
种属内	ZGPAT	Q8N5A5	DHX15	Homo sapiens	O43143	Y2H Prey Pooling	25416956
种属内	ZGPAT	Q8N5A5	DHX15	Homo sapiens	O43143	Validated Y2H	25416956
种属内	ZGPAT	Q8N5A5	KIFC3	Homo sapiens	Q9BVG8	Y2H	21516116
种属内	ZGPAT	Q8N5A5	KIFC3	Homo sapiens	Q9BVG8	Validated Y2H	25416956
种属内	ZGPAT	Q8N5A5	KIFC3	Homo sapiens	Q9BVG8	Y2H Array	25416956
种属内	ZGPAT	Q8N5A5	TRIM54	Homo sapiens	Q9BYV2	Validated Y2H	25416956
种属内	ZGPAT	Q8N5A5	TRIM54	Homo sapiens	Q9BYV2	Y2H Array	25416956
种属内	ZGPAT	Q8N5A5	SSX2IP	Homo sapiens	Q9Y2D8	Y2H	21516116
种属内	ZGPAT	Q8N5A5	SSX2IP	Homo sapiens	Q9Y2D8	Validated Y2H	25416956
种属内	ZGPAT	Q8N5A5	SSX2IP	Homo sapiens	Q9Y2D8	Y2H Array	25416956
种属内	ZGPAT	Q8N5A5	BLZF1	Homo sapiens	Q9H2G9	Y2H Array	25416956
种属内	ZGPAT	Q8N5A5	MIPOL1	Homo sapiens	Q8TD10	Y2H Array	25416956
种属内	ZGPAT	Q8N5A5	MIPOL1	Homo sapiens	Q8TD10	Validated Y2H	25416956
种属内	ZGPAT	Q8N5A5	CCDC57	Homo sapiens	Q2TAC2	Y2H Prey Pooling	25416956
种属内	ZGPAT	Q8N5A5	GOLGA2	Homo sapiens	Q08379	Validated Y2H	25416956
种属内	ZGPAT	Q8N5A5	PHC2	Homo sapiens	Q8IXK0	Validated Y2H	25416956
种属内	ZGPAT	Q8N5A5	PHC2	Homo sapiens	Q8IXK0	Y2H Array	25416956
种属内	ZGPAT	Q8N5A5	TLE5	Homo sapiens	Q08117	Validated Y2H	25416956
种属内	ZGPAT	Q8N5A5	TLE5	Homo sapiens	Q08117	Y2H Prey Pooling	25416956
种属内	ZGPAT	Q8N5A5	TLE5	Homo sapiens	Q08117	Y2H Array	25416956
种属内	ZGPAT	Q8N5A5	TRIM27	Homo sapiens	P14373	Validated Y2H	25416956
种属内	ZGPAT	Q8N5A5	TRIM27	Homo sapiens	P14373	Y2H Array	25416956
种属内	ZGPAT	Q8N5A5	BEND5	Homo sapiens	Q7L4P6	Y2H Array	25416956
种属内	ZGPAT	Q8N5A5	BEND5	Homo sapiens	Q7L4P6	Validated Y2H	25416956
种属内	ZGPAT	Q8N5A5	KRT15	Homo sapiens	P19012	Y2H Array	25416956
种属内	ZGPAT	Q8N5A5	CEP70	Homo sapiens	Q8NHQ1	Validated Y2H	25416956
种属内	ZGPAT	Q8N5A5	DYDC1	Homo sapiens	Q8WWB3	Validated Y2H	25416956
种属内	ZGPAT	Q8N5A5	DYDC1	Homo sapiens	Q8WWB3	Y2H Array	25416956
种属内	ZGPAT	Q8N5A5	DYDC1	Homo sapiens	Q8WWB3	Y2H Prey Pooling	25416956
种属内	ZGPAT	Q8N5A5	LDOC1	Homo sapiens	O95751	Y2H Array	31515488
种属内	ZGPAT	Q8N5A5	LZTS2	Homo sapiens	Q9BRK4	Y2H Prey Pooling	25416956
种属内	ZGPAT	Q8N5A5	ZBTB8A	Homo sapiens	Q96BR9	Y2H Prey Pooling	25416956
种属内	ZGPAT	Q8N5A5	ZBTB8A	Homo sapiens	Q96BR9	Validated Y2H	25416956
种属内	ZGPAT	Q8N5A5	ZBTB8A	Homo sapiens	Q96BR9	Y2H Array	25416956
种属内	ZGPAT	Q8N5A5	AIMP2	Homo sapiens	Q13155	Y2H Prey Pooling	25416956
种属内	ZGPAT	Q8N5A5	AIMP2	Homo sapiens	Q13155	Y2H Array	25416956
种属内	ZGPAT	Q8N5A5	AIMP2	Homo sapiens	Q13155	Validated Y2H	25416956
种属内	ZGPAT	Q8N5A5	STAC3	Homo sapiens	Q96MF2	Y2H Prey Pooling	25416956
种属内	ZGPAT	Q8N5A5	IKZF3	Homo sapiens	Q9UKT9	Y2H Prey Pooling	25416956
种属内	ZGPAT	Q8N5A5	IKZF3	Homo sapiens	Q9UKT9	Y2H Array	25416956
种属内	ZGPAT	Q8N5A5	CCNDBP1	Homo sapiens	O95273	Y2H Prey Pooling	25416956
种属内	ZGPAT	Q8N5A5	CCNDBP1	Homo sapiens	O95273	Y2H	21516116

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Melnick-Needles Syndrome

MNS	Melnick-Needles Osteodysplasty
Osteodysplasty Of Melnick And Needles	Osteochondrodysplasias

Otopalatodigital Syndrome Spectrum Disorder

Opd Spectrum Disorder	Opsd
Fronto-Otopalatodigital Osteodysplasia

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS16066	ZGPAT Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	ZGPAT	MGD	MGI:2449939
Macaca mulatta	ZGPAT	VGNC	VGNC:98469
Canis familiaris	ZGPAT	VGNC	VGNC:54747
Bos taurus	ZGPAT	VGNC	VGNC:57036
Rattus norvegicus	ZGPAT	RGD	RGD:1310801

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