PHC2 - polyhomeotic homolog 2 Gene

中文名称：多同源同系物 2

种属: Homo sapiens

同用名: PH2; EDR2; HPH2

关于 PHC2

功能概要

在果蝇中，基因的“多梳”组 (PcG) 是负责基因活性稳定遗传的细胞记忆系统的一部分。 PcG 蛋白形成一个大的多聚体、染色质相关蛋白复合物。由该基因编码的蛋白质与果蝇 PcG 蛋白“多同源” (Ph) 具有同源性，并且已知与 EDR1 异二聚化并与 BMI1 在人类细胞间期核中共定位。在人体细胞中的具体功能尚未确定。已发现该基因的两个转录本变体编码不同的亚型。[RefSeq 提供，2008 年 7 月]

In Drosophila melanogaster, the 'Polycomb' group (PcG) of genes are part of a cellular memory system that is responsible for the stable inheritance of gene activity. PcG proteins form a large multimeric, chromatin-associated protein complex. The protein encoded by this gene has homology to the Drosophila PcG protein 'polyhomeotic' (Ph) and is known to heterodimerize with EDR1 and colocalize with BMI1 in interphase nuclei of human cells. The specific function in human cells has not yet been determined. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]