LMO1 - LIM domain only 1 Gene

中文名称：仅 LIM 域 1

种属: Homo sapiens

同用名: TTG1; RBTN1; RHOM1

关于 LMO1

功能概要

该基因座编码一个转录调节器，该调节器包含两个富含半胱氨酸的 LIM 结构域，但缺少 DNA 结合结构域。 LIM 结构域可能在蛋白质相互作用中发挥作用；因此，编码的蛋白质可以通过竞争性结合特定的 DNA 结合转录因子来调节转录。该基因座的改变与急性淋巴细胞 T 细胞白血病有关。在该基因座和至少两个基因座之间观察到染色体重排，即 T 细胞抗原受体基因的 delta 亚基和 LIM 结构域结合 1 基因。已经描述了选择性剪接的转录物变体。[RefSeq 提供，2012 年 7 月]

This locus encodes a transcriptional regulator that contains two cysteine-rich LIM domains but lacks a DNA-binding domain. LIM domains may play a role in protein interactions; thus the encoded protein may regulate transcription by competitively binding to specific DNA-binding transcription factors. Alterations at this locus have been associated with acute lymphoblastic T-cell leukemia. Chromosomal rearrangements have been observed between this locus and at least two loci, the delta subunit of the T-cell antigen receptor gene and the LIM domain binding 1 gene. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2012]