1. Gene
  2. ZNF24 - zinc finger protein 24 Gene

ZNF24 - zinc finger protein 24 Gene

中文名称:锌指蛋白 24

种属: Homo sapiens

同用名: KOX17; RSG-A; ZNF191; ZSCAN3; Zfp191

基因 ID: 7572 | 基因类型: protein coding

关于 ZNF24

Cytogenetic location: 18q12.2 Genomic coordinates (GRCh38): 18:35,332,227-35,344,420 (from NCBI)

This gene has 6 transcripts (splice variants), 105 orthologues and 31 paralogues. Ubiquitous expression in thyroid (RPKM 22.0), brain (RPKM 18.9) and 25 other tissues.

功能概要

启用 DNA 结合转录激活剂活性,RNA 聚合酶 II 特异性;相同的蛋白质结合活性;和序列特异性 DNA 结合活性。参与转录的负调控、DNA 模板化和 RNA 聚合酶 II 对转录的正调控。位于核质中。 [由基因组资源联盟提供,2022 年 4 月]

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; identical protein binding activity; and sequence-specific DNA binding activity. Involved in negative regulation of transcription, DNA-templated and positive regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

ZNF24 基因产物(3)

mRNA Protein Name
NM_001308123.2 NP_001295052.1 zinc finger protein 24 isoform 2
NM_001375815.1 NP_001362744.1 zinc finger protein 24 isoform 1
NM_006965.4 NP_008896.2 zinc finger protein 24 isoform 1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
11532988 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
31515488 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16169070 GOA
enables sequence-specific DNA binding IDA
IDA: 通过直接分析推断
11532988 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
10585455 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
11532988 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

ZNF24 蛋白结构

SCAN

SCAN: SCAN domain (47 - 140)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (268 - 290)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (294 - 317)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (322 - 345)

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  • 368 a.a.
蛋白主名 其他名称

zinc finger protein 24

retinoic acid suppression protein A

ZNF24 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra ZNF24 P17028 ZSCAN22 Homo sapiens P10073
Y2H Array
32296183
Intra ZNF24 P17028 ZSCAN22 Homo sapiens P10073
Y2H Prey Pooling
32296183
Intra ZNF24 P17028 UBE2I Homo sapiens Q7KZS0
Y2H Array
32296183
Intra ZNF24 P17028 UBE2I Homo sapiens Q7KZS0
Y2H Prey Pooling
32296183
Intra ZNF24 P17028 UBE2I Homo sapiens Q7KZS0
Validated Y2H
32296183
Intra ZNF24 P17028 ZGPAT Homo sapiens Q8N5A5-2
Validated Y2H
32296183
Intra ZNF24 P17028 ZNF483 Homo sapiens Q6P088
Y2H Array
25416956
Intra ZNF24 P17028 ZSCAN21 Homo sapiens Q9Y5A6
Validated Y2H
32296183
Intra ZNF24 P17028 PGBD1 Homo sapiens Q96JS3
Y2H Array
31515488
Intra ZNF24 P17028 PGBD1 Homo sapiens Q96JS3
Y2H Array
25416956
Intra ZNF24 P17028 ZNF174 Homo sapiens Q15697-2
Validated Y2H
32296183
Intra ZNF24 P17028 ZNF174 Homo sapiens Q15697-2
Anti Tag CoIP
28514442
Intra ZNF24 P17028 ZNF410 Homo sapiens Q86VK4-3
Validated Y2H
32296183
Intra ZNF24 P17028 NEK6 Homo sapiens Q9HC98-4
Validated Y2H
32296183
Intra ZNF24 P17028 LMO2 Homo sapiens P25791-3
Validated Y2H
32296183
Intra ZNF24 P17028 ZNF444 Homo sapiens Q8N0Y2-2
Validated Y2H
32296183
Intra ZNF24 P17028 APOE Homo sapiens P02649
Validated Y2H
32814053
Intra ZNF24 P17028 APOE Homo sapiens P02649
Y2H Array
32814053
Intra ZNF24 P17028 APOE Homo sapiens P02649
Y2H Pooling
32814053
Intra ZNF24 P17028 ZNF396 Homo sapiens Q96N95-3
Validated Y2H
32296183
Intra ZNF24 P17028 ZNF396 Homo sapiens Q96N95-3
Y2H Array
32296183
Intra ZNF24 P17028 ZNF396 Homo sapiens Q96N95-3
Y2H Prey Pooling
32296183
Intra ZNF24 P17028 ZNF396 Homo sapiens Q96N95-3
MAPPIT
32296183
Intra ZNF24 P17028 MAP1LC3C Homo sapiens Q9BXW4
Validated Y2H
32296183
Intra ZNF24 P17028 ZKSCAN4 Homo sapiens Q969J2
Y2H Array
31515488
Intra ZNF24 P17028 ZKSCAN4 Homo sapiens Q969J2
Validated Y2H
32296183
Intra ZNF24 P17028 SQSTM1 Homo sapiens Q13501
Validated Y2H
32814053
Intra ZNF24 P17028 SQSTM1 Homo sapiens Q13501
Y2H Array
32814053
Intra ZNF24 P17028 SQSTM1 Homo sapiens Q13501
Y2H Pooling
32814053
Intra ZNF24 P17028 DDX6 Homo sapiens P26196
Validated Y2H
25416956
Intra ZNF24 P17028 DDX6 Homo sapiens P26196
Y2H Prey Pooling
25416956
Intra ZNF24 P17028 DDX6 Homo sapiens P26196
Y2H Array
25416956
Intra ZNF24 P17028 ZNF446 Homo sapiens Q9NWS9
Anti Tag CoIP
28514442
Intra ZNF24 P17028 ZNF446 Homo sapiens Q9NWS9
Anti Tag CoIP
33961781
Intra ZNF24 P17028 ZNF446 Homo sapiens Q9NWS9
Y2H Array
20211142
Intra ZNF24 P17028 ZNF620 Homo sapiens Q6ZNG0
Validated Y2H
32296183
Intra ZNF24 P17028 ZNF620 Homo sapiens Q6ZNG0
Y2H Prey Pooling
32296183
Intra ZNF24 P17028 ZNF620 Homo sapiens Q6ZNG0
Y2H Array
32296183
Intra ZNF24 P17028 SPRED1 Homo sapiens Q7Z699
Y2H Array
32814053
Intra ZNF24 P17028 SPRED1 Homo sapiens Q7Z699
Y2H Pooling
32814053
Intra ZNF24 P17028 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32814053
Intra ZNF24 P17028 ZSCAN23 Homo sapiens Q3MJ62
Validated Y2H
32296183
Intra ZNF24 P17028 ZSCAN32 Homo sapiens Q9NX65
Y2H Prey Pooling
25416956
Intra ZNF24 P17028 ZSCAN32 Homo sapiens Q9NX65
Validated Y2H
25416956
Intra ZNF24 P17028 ZSCAN32 Homo sapiens Q9NX65
Y2H Array
25416956
Intra ZNF24 P17028 ZSCAN32 Homo sapiens Q9NX65
Y2H Pooling
16189514
Intra ZNF24 P17028 YJU2B Homo sapiens P13994
Y2H Pooling
16189514
Intra ZNF24 P17028 YJU2B Homo sapiens P13994
Y2H Array
31515488
Intra ZNF24 P17028 YJU2B Homo sapiens P13994
Y2H Prey Pooling
32296183
Intra ZNF24 P17028 YJU2B Homo sapiens P13994
Y2H Array
32296183
Intra ZNF24 P17028 FAM161A Homo sapiens Q3B820
Validated Y2H
32296183
Intra ZNF24 P17028 ZSCAN16 Homo sapiens Q9H4T2
Validated Y2H
32296183
Intra ZNF24 P17028 LMO2 Homo sapiens P25791
Y2H Array
25416956
Intra ZNF24 P17028 LMO2 Homo sapiens P25791
Y2H Prey Pooling
25416956
Intra ZNF24 P17028 ZNF446 Homo sapiens Q9NWS9-2
Y2H Prey Pooling
25416956
Intra ZNF24 P17028 ZNF446 Homo sapiens Q9NWS9-2
Complementation
32296183
Intra ZNF24 P17028 ZNF446 Homo sapiens Q9NWS9-2
Y2H Pooling
16189514
Intra ZNF24 P17028 ZNF446 Homo sapiens Q9NWS9-2
Validated Y2H
32296183
Intra ZNF24 P17028 ZNF446 Homo sapiens Q9NWS9-2
MAPPIT
32296183
Intra ZNF24 P17028 ZNF165 Homo sapiens P49910
Y2H Array
32296183
Intra ZNF24 P17028 ZNF165 Homo sapiens P49910
Y2H Prey Pooling
32296183
Intra ZNF24 P17028 ZNF165 Homo sapiens P49910
Validated Y2H
32296183
Intra ZNF24 P17028 SCAND1 Homo sapiens P57086
Validated Y2H
32296183
Intra ZNF24 P17028 SCAND1 Homo sapiens P57086
Y2H Pooling
16189514
Intra ZNF24 P17028 SCAND1 Homo sapiens P57086
Anti Tag CoIP
28514442
Intra ZNF24 P17028 SCAND1 Homo sapiens P57086
Anti Tag CoIP
33961781
Intra ZNF24 P17028 APLP1 Homo sapiens P51693
Y2H Pooling
16169070
Intra ZNF24 P17028 ZNF232 Homo sapiens Q9UNY5
Validated Y2H
32296183
Intra ZNF24 P17028 TCAF1 Homo sapiens Q9Y4C2
Y2H Prey Pooling
25416956
Intra ZNF24 P17028 TCAF1 Homo sapiens Q9Y4C2
Y2H Array
25416956
Intra ZNF24 P17028 LMO1 Homo sapiens P25800
Validated Y2H
32296183
Intra ZNF24 P17028 DZIP3 Homo sapiens Q86Y13
Y2H Array
29892012
Intra ZNF24 P17028 DZIP3 Homo sapiens Q86Y13
Y2H Prey Pooling
25416956
Intra ZNF24 P17028 DZIP3 Homo sapiens Q86Y13
Y2H Array
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

直系同源

种属 基因名 来源 基因 ID
Felis catus ZNF24 VGNC VGNC:107735
Mus musculus ZNF24 MGD MGI:1929704
Macaca mulatta ZNF24 VGNC VGNC:81614
Rattus norvegicus ZNF24 RGD RGD:727963
Bos taurus ZNF24 VGNC VGNC:37232
Canis familiaris ZNF24 VGNC VGNC:48680