2. Gene
  3. VBP1 - VHL binding protein 1 Gene

VBP1 - VHL binding protein 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：VHL 结合蛋白 1

种属: Homo sapiens

同用名: PFD3; PFDN3; VBP-1; HIBBJ46

基因 ID: 7411 | 基因类型: protein coding

关于 VBP1

Cytogenetic location: Xq28 Genomic coordinates (GRCh38): X:155,197,007-155,239,841 (from NCBI)

This gene has 4 transcripts (splice variants) and 218 orthologues. Ubiquitous expression in brain (RPKM 27.3), heart (RPKM 18.7) and 25 other tissues.

功能概要

该基因编码的蛋白质与 Von Hippel-Lindau 蛋白相互作用形成细胞内复合物。编码的蛋白质起伴侣蛋白的作用，并可能在 Von Hippel-Lindau 蛋白从核周颗粒向细胞核或细胞质的转运中发挥作用。可变剪接和替代转录起始位点的使用导致编码不同蛋白质亚型的多个转录变体。[RefSeq 提供，2015 年 1 月]

The protein encoded by this gene interacts with the Von Hippel-Lindau protein to form an intracellular complex. The encoded protein functions as a chaperone protein, and may play a role in the transport of the Von Hippel-Lindau protein from the perinuclear granules to the nucleus or cytoplasm. Alternative splicing and the use of alternate transcription start sites results in multiple transcript variants encoding different protein isoforms. [provided by RefSeq, Jan 2015]

VBP1 基因产物(4)

mRNA Protein Name
NM_001303543.1 NP_001290472.1 prefoldin subunit 3 isoform 2
NM_001303544.1 NP_001290473.1 prefoldin subunit 3 isoform 3
NM_001303545.1 NP_001290474.1 prefoldin subunit 3 isoform 4
NM_003372.7 NP_003363.1 prefoldin subunit 3 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables amyloid-beta binding IDA
IDA: 通过直接分析推断
23614719 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
17698809 GOA
enables unfolded protein binding IDA
IDA: 通过直接分析推断
30955883 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of amyloid fibril formation IDA
IDA: 通过直接分析推断
23614719 GOA
involved in protein folding IDA
IDA: 通过直接分析推断
30955883 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of prefoldin complex IDA
IDA: 通过直接分析推断
23614719 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

VBP1 蛋白结构

Prefoldin

Prefoldin: Prefoldin subunit (60 - 182)

  • 0
  • 100
  • 197 a.a.
蛋白主名 其他名称

prefoldin subunit 3

von Hippel-Lindau binding protein 1

VBP1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
VBP1 P61758 SULT1B1 Homo sapiens O43704
Validated Y2H
32814053
种属内
VBP1 P61758 SULT1B1 Homo sapiens O43704
Y2H Pooling
32814053
种属内
VBP1 P61758 SULT1B1 Homo sapiens O43704
Y2H Array
32814053
种属内
VBP1 P61758 ZNF410 Homo sapiens Q86VK4-3
Validated Y2H
32296183
种属内
VBP1 P61758 LMO3 Homo sapiens Q8TAP4-4
Validated Y2H
32296183
种属内
VBP1 P61758 TCEANC Homo sapiens Q8N8B7-2
Validated Y2H
32296183
种属内
VBP1 P61758 VEZF1 Homo sapiens Q14119
Validated Y2H
32296183
种属内
VBP1 P61758 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
种属内
VBP1 P61758 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
种属内
VBP1 P61758 MEOX2 Homo sapiens Q6FHY5
Validated Y2H
32296183
种属内
VBP1 P61758 THAP3 Homo sapiens Q8WTV1
Y2H Pooling
32814053
种属内
VBP1 P61758 THAP3 Homo sapiens Q8WTV1
Validated Y2H
32814053
种属内
VBP1 P61758 THAP3 Homo sapiens Q8WTV1
Y2H Array
32814053
种属内
VBP1 P61758 MISP Homo sapiens Q8IVT2
Validated Y2H
32296183
种属内
VBP1 P61758 ZNF488 Homo sapiens Q96MN9-2
Validated Y2H
32814053
种属内
VBP1 P61758 ZNF488 Homo sapiens Q96MN9-2
Y2H Pooling
32814053
种属内
VBP1 P61758 ZNF488 Homo sapiens Q96MN9-2
Y2H Array
32814053
种属内
VBP1 P61758 UBL7 Homo sapiens Q96S82
Y2H Prey Pooling
25416956
种属内
VBP1 P61758 UBL7 Homo sapiens Q96S82
Y2H Prey Pooling
32296183
种属内
VBP1 P61758 UBL7 Homo sapiens Q96S82
Validated Y2H
25416956
种属内
VBP1 P61758 UBL7 Homo sapiens Q96S82
Validated Y2H
32296183
种属内
VBP1 P61758 UBL7 Homo sapiens Q96S82
Anti Tag CoIP
33961781
种属内
VBP1 P61758 UBL7 Homo sapiens Q96S82
Y2H Array
32296183
种属内
VBP1 P61758 UBL7 Homo sapiens Q96S82
Anti Tag CoIP
28514442
种属内
VBP1 P61758 PFDN4 Homo sapiens Q9NQP4
Validated Y2H
32296183
种属内
VBP1 P61758 PFDN4 Homo sapiens Q9NQP4
Y2H Array
32296183
种属内
VBP1 P61758 PFDN4 Homo sapiens Q9NQP4
Y2H Prey Pooling
25416956
种属内
VBP1 P61758 PFDN4 Homo sapiens Q9NQP4
Y2H Prey Pooling
32296183
种属内
VBP1 P61758 PFDN5 Homo sapiens Q99471
Y2H Array
32296183
种属内
VBP1 P61758 PFDN5 Homo sapiens Q99471
Anti Tag CoIP
33961781
种属内
VBP1 P61758 PFDN5 Homo sapiens Q99471
Anti Tag CoIP
28514442
种属内
VBP1 P61758 PFDN5 Homo sapiens Q99471
Y2H Prey Pooling
32296183
种属内
VBP1 P61758 PFDN5 Homo sapiens Q99471
Validated Y2H
32296183
种属内
VBP1 P61758 PFDN2 Homo sapiens Q9UHV9
Y2H Array
32814053
种属内
VBP1 P61758 PFDN2 Homo sapiens Q9UHV9
Y2H Pooling
32814053
种属内
VBP1 P61758 PFDN2 Homo sapiens Q9UHV9
Validated Y2H
32296183
种属内
VBP1 P61758 PFDN2 Homo sapiens Q9UHV9
Validated Y2H
32814053
种属内
VBP1 P61758 ZNF576 Homo sapiens Q9H609
Validated Y2H
32296183
种属内
VBP1 P61758 GABPB1 Homo sapiens Q06547-2
Validated Y2H
32814053
种属内
VBP1 P61758 GABPB1 Homo sapiens Q06547-2
Y2H Pooling
32814053
种属内
VBP1 P61758 GABPB1 Homo sapiens Q06547-2
Y2H Array
32814053
种属内
VBP1 P61758 GLIS2 Homo sapiens Q9BZE0
Validated Y2H
32296183
种属内
VBP1 P61758 TSC22D4 Homo sapiens Q9Y3Q8
Y2H Prey Pooling
32296183
种属内
VBP1 P61758 TSC22D4 Homo sapiens Q9Y3Q8
Validated Y2H
32296183
种属内
VBP1 P61758 TSC22D4 Homo sapiens Q9Y3Q8
Y2H Array
32296183
种属内
VBP1 P61758 DDIT4L Homo sapiens Q96D03
Validated Y2H
32296183
种属内
VBP1 P61758 EFHC1 Homo sapiens Q5JVL4
Validated Y2H
32296183
种属内
VBP1 P61758 ENKD1 Homo sapiens Q9H0I2
Validated Y2H
32296183
种属内
VBP1 P61758 MYOZ1 Homo sapiens Q9NP98
Validated Y2H
32296183
种属内
VBP1 P61758 ZNF581 Homo sapiens Q9P0T4
Y2H Array
32814053
种属内
VBP1 P61758 ZNF581 Homo sapiens Q9P0T4
Y2H Pooling
32814053
种属内
VBP1 P61758 ZNF581 Homo sapiens Q9P0T4
Validated Y2H
32814053
种属内
VBP1 P61758 IKZF3 Homo sapiens Q9UKT9
Validated Y2H
32296183
种属内
VBP1 P61758 IKZF3 Homo sapiens Q9UKT9
Y2H Array
32296183
种属内
VBP1 P61758 IKZF3 Homo sapiens Q9UKT9
Y2H Prey Pooling
32296183
种属内
VBP1 P61758 ZNF232 Homo sapiens Q9UNY5
Validated Y2H
32814053
种属内
VBP1 P61758 ZNF232 Homo sapiens Q9UNY5
Y2H Pooling
32814053
种属内
VBP1 P61758 ZNF232 Homo sapiens Q9UNY5
Y2H Array
32814053
种属内
VBP1 P61758 AIRIM Homo sapiens Q9NX04
Validated Y2H
32296183
种属内
VBP1 P61758 BECN1 Homo sapiens Q14457
Validated Y2H
32814053
种属内
VBP1 P61758 BECN1 Homo sapiens Q14457
Y2H Array
32814053
种属内
VBP1 P61758 BECN1 Homo sapiens Q14457
Y2H Pooling
32814053
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
X-Linked Intellectual Disability-Cardiomegaly-Congestive Heart Failure Syndrome

Mental Retardation, X-Linked, Syndromic 32

Mrxs32
Non-Syndromic X-Linked Intellectual Disability 72

Mrx72
Hypomelanosis Of Ito

Incontinentia Pigmenti Achromians

Nevus Of Ito

Ipa

Ito Hypomelanosis

Ito

Pigmentation Disorders

HMI

Incontinentia Pigmenti, Type I, Formerly

Ip1, Formerly

Bloch-Siemans Syndrome

Incontinentia Pigmenti Achromians Syndrome

Ito'S Nevus

Incontinentia Pigmenti Type 1

Nevi Of Ito

Nevus Fuscocaeruleus Acromiodeltoideus

Bloch Sulzberger Syndrome

Skin Pigmentation Disorder
Schimmelpenning-Feuerstein-Mims Syndrome

Nevus Sebaceus Of Jadassohn

Organoid Nevus Phakomatosis

Linear Nevus Sebaceous Syndrome

Sfm Syndrome

Jadassohn Nevus Phakomatosis

Jnp

Schimmelpenning Syndrome

Solomon Syndrome

SFM

Linear Sebaceous Nevus Syndrome

Schimmelpenning-Feuerstein-Mims Syndrome, Somatic Mosaic

Nevus Sebaceus Syndrome

Organoid Nevus Syndrome

Schimmelpenning Feuerstein Mims Syndrome

Sebaceous Nevus Syndrome, Linear

Epidermal Nevus Syndrome, Formerly

Sebaceous Nevus Syndrome Linear

Linear Nevus Sebaceus Syndrome

Epidermal Nevus Syndrome

Ss

Nevus Sebaceous
Non-Syndromic X-Linked Intellectual Disability

X-Linked Non-Syndromic Intellectual Disability

Non-Specific X-Linked Mental Retardation

X-Linked Non-Specific Intellectual Disability
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS15617 VBP1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus VBP1 VGNC VGNC:36777
Mus musculus VBP1 MGD MGI:1333804
Rattus norvegicus VBP1 RGD RGD:1590535
Canis familiaris VBP1 VGNC VGNC:48239
Felis catus VBP1 VGNC VGNC:66929
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