2. Gene
  3. THAP3 - THAP domain containing 3 Gene

THAP3 - THAP domain containing 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：含 THAP 域 3

种属: Homo sapiens

基因 ID: 90326 | 基因类型: protein coding

关于 THAP3

Cytogenetic location: 1p36.31 Genomic coordinates (GRCh38): 1:6,624,868-6,635,595 (from NCBI)

This gene has 8 transcripts (splice variants), 148 orthologues and 7 paralogues. Ubiquitous expression in kidney (RPKM 8.5), spleen (RPKM 6.2) and 25 other tissues.

功能概要

预测可启用 DNA 结合活性和金属离子结合活性。参与 RNA 聚合酶 II 对转录的正调控。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable DNA binding activity and metal ion binding activity. Involved in positive regulation of transcription by RNA polymerase II. [provided by Alliance of Genome Resources, Apr 2022]

THAP3 基因产物(8)

mRNA Protein Name
NM_001195752.2 NP_001182681.1 THAP domain-containing protein 3 isoform 1
NM_001195753.2 NP_001182682.1 THAP domain-containing protein 3 isoform 3
NM_001394496.1 NP_001381425.1 THAP domain-containing protein 3 isoform 4
NM_001394497.1 NP_001381426.1 THAP domain-containing protein 3 isoform 5
NM_001394498.1 NP_001381427.1 THAP domain-containing protein 3 isoform 6
NM_001394499.1 NP_001381428.1 THAP domain-containing protein 3 isoform 7
NM_001394500.1 NP_001381429.1 THAP domain-containing protein 3 isoform 8
NM_138350.4 NP_612359.2 THAP domain-containing protein 3 isoform 2
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
20200153 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
20200153 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

THAP3 蛋白结构

THAP

THAP: THAP domain (3 - 86)

  • 0
  • 100
  • 200
  • 239 a.a.
蛋白主名 其他名称

THAP domain-containing protein 3

THAP domain containing, apoptosis associated protein 3

THAP3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra THAP3 Q8WTV1 UBL5 Homo sapiens Q9BZL1
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Brain Malformations With Or Without Urinary Tract Defects

Chromosome 1p32-P31 Deletion Syndrome

Nfia-Related Disorder

Chromosome 1, Monosomy 1p32

BRMUTD

1p31p32 Microdeletion Syndrome

Nfia Haploinsufficiency

Del(1)(P31p32)

Monosomy 1p31p32

Nfia-Related Disorders
Dystonia 3, Torsion, X-Linked

X-Linked Dystonia-Parkinsonism

DYT3

Xdp

Lubag

Dystonia-Parkinsonism, X-Linked

Torsion Dystonia-Parkinsonism, Filipino Type

Dyt-Taf1

X-Linked Dystonia-Parkinsonism Syndrome

X-Linked Torsion Dystonia-Parkinsonism Syndrome

Dystonia Musculorum Deformans

X-Linked Dystonia-Parkinsonism/Lubag

Lubag Syndrome

Dystonia-3

Torsion Dystonia-Parkinsonism Filipino Type

X-Linked Torsion Dystonia 3

Dystonia, Torsion, X-Linked, Type 3
Chromosome 1p36 Deletion Syndrome

1p36 Deletion Syndrome

Deletion 1p36

Monosomy 1p36

Subtelomeric 1p36 Deletion

Monosomy 1p36 Syndrome

Distal Monosomy 1p36

Del(1)(P36)

Deletion 1pter

Monosomy 1pter
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14474 THAP3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus THAP3 VGNC VGNC:66150
Rattus norvegicus THAP3 RGD RGD:1308109
Macaca mulatta THAP3 VGNC VGNC:79290
Mus musculus THAP3 MGD MGI:1917126
Bos taurus THAP3 VGNC VGNC:35822
Canis familiaris THAP3 VGNC VGNC:47328
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