UBL5 - ubiquitin like 5 Gene

中文名称：泛素样 5

种属: Homo sapiens

同用名: HUB1

关于 UBL5

功能概要

该基因编码一组类似于泛素的蛋白质。编码的蛋白质被认为不会像泛素那样降解蛋白质，而是通过异肽键与靶蛋白结合来影响它们的功能。基于其在 Psammomys obesus (肥胖沙鼠) 中的表达，该基因产物已被研究为与肥胖易感性的联系，这是肥胖研究的动物模型。发现该基因的变异与某些代谢特征 (PMID: 15331561) 显着相关，但与儿童肥胖无关 (PMID: 19189687) 。该基因的假基因位于 3、5 和 17 号染色体上。已鉴定出编码相同蛋白质的多个选择性剪接变体。[RefSeq 提供，2013 年 1 月]

This gene encodes a member of a group of proteins similar to ubiquitin. The encoded protein is not thought to degrade proteins like ubiquitin but to affect their function through being bound to target proteins by an isopeptide bond. The gene product has been studied as a link to predisposition to obesity based on its expression in Psammomys obesus, the fat sand rat, which is an animal model for obesity studies. Variation in this gene was found to be significantly associated with some metabolic traits (PMID: 15331561) but not associated with childhood obesity (PMID: 19189687). Pseudogenes of this gene are located on chromosomes 3, 5 and 17. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2013]