2. Gene
  3. PRMT8 - protein arginine methyltransferase 8 Gene

PRMT8 - protein arginine methyltransferase 8 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：蛋白质精氨酸甲基转移酶 8

种属: Homo sapiens

同用名: HRMT1L3; HRMT1L4

基因 ID: 56341 | 基因类型: protein coding

关于 PRMT8

Cytogenetic location: 12p13.32 Genomic coordinates (GRCh38): 12:3,381,349-3,593,973 (from NCBI)

This gene has 4 transcripts (splice variants), 281 orthologues and 7 paralogues. Biased expression in brain (RPKM 5.7), testis (RPKM 0.8) and 1 other tissue.

功能概要

精氨酸甲基化是一种广泛存在的翻译后修饰，由精氨酸甲基转移酶 (如 PRMT8) 介导。精氨酸甲基化参与许多细胞过程，包括 DNA 修复、RNA 转录、信号转导、蛋白质区室化和可能的蛋白质翻译 (Lee 等人，2005 [PubMed 16051612]) 。[OMIM 提供，2008 年 3 月]

Arginine methylation is a widespread posttranslational modification mediated by arginine methyltransferases, such as PRMT8. Arginine methylation is involved in a number of cellular processes, including DNA repair, RNA transcription, signal transduction, protein compartmentalization, and possibly protein translation (Lee et al., 2005 [PubMed 16051612]).[supplied by OMIM, Mar 2008]

PRMT8 基因产物(9)

mRNA Protein Name
NM_001256536.1 NP_001243465.1 protein arginine N-methyltransferase 8 isoform 2
XM_047429157.1 XP_047285113.1 protein arginine N-methyltransferase 8 isoform X3
XM_047429159.1 XP_047285115.1 protein arginine N-methyltransferase 8 isoform X5
XM_017019644.2 XP_016875133.1 protein arginine N-methyltransferase 8 isoform X1
XM_017019645.1 XP_016875134.1 protein arginine N-methyltransferase 8 isoform X2
XM_047429158.1 XP_047285114.1 protein arginine N-methyltransferase 8 isoform X4
NM_001256537.1
NR_046301.1
NM_019854.5 NP_062828.3 protein arginine N-methyltransferase 8 isoform 1

PRMT8 蛋白结构

PrmA

PrmA: Ribosomal protein L11 methyltransferase (PrmA) (108 - 184)

  • 0
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  • 300
  • 394 a.a.
蛋白主名 其他名称

protein arginine N-methyltransferase 8

HMT1 hnRNP methyltransferase-like 3

arginine methyltransferase 8

heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 4

protein arginine N-methyltransferase 4

相关产品

Pre-clinical Phase
生物活性分子 (8)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-19615 MS023 Inhibitor 99.73% 否
HY-12970A EPZ020411 hydrochloride Inhibitor 98.15% 否
HY-12970 EPZ020411 Inhibitor 98.06% 否
HY-19615B MS023 dihydrochloride Inhibitor 99.78% 否
HY-100360 MS049 Inhibitor ≥98.0% 否
HY-128717B GSK3368715 trihydrochloride Inhibitor / 否
HY-146810 PRMT4-IN-1 Inhibitor / 否
HY-161334 CARM1-IN-4 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus PRMT8 RGD RGD:1587677
Mus musculus PRMT8 MGD MGI:3043083
Felis catus PRMT8 VGNC VGNC:67652
Bos taurus PRMT8 VGNC VGNC:33353
Canis familiaris PRMT8 VGNC VGNC:45001
Macaca mulatta PRMT8 VGNC VGNC:76360
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