2. Gene
  3. PRMT8 - protein arginine methyltransferase 8 Gene

PRMT8 - protein arginine methyltransferase 8 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：蛋白质精氨酸甲基转移酶 8

种属: Homo sapiens

同用名: HRMT1L3; HRMT1L4

基因 ID: 56341 | 基因类型: protein coding

关于 PRMT8

Cytogenetic location: 12p13.32 Genomic coordinates (GRCh38): 12:3,381,349-3,593,973 (from NCBI)

This gene has 4 transcripts (splice variants), 281 orthologues and 7 paralogues. Biased expression in brain (RPKM 5.7), testis (RPKM 0.8) and 1 other tissue.

功能概要

精氨酸甲基化是一种广泛存在的翻译后修饰，由精氨酸甲基转移酶 (如 PRMT8) 介导。精氨酸甲基化参与许多细胞过程，包括 DNA 修复、RNA 转录、信号转导、蛋白质区室化和可能的蛋白质翻译 (Lee 等人，2005 [PubMed 16051612]) 。[OMIM 提供，2008 年 3 月]

Arginine methylation is a widespread posttranslational modification mediated by arginine methyltransferases, such as PRMT8. Arginine methylation is involved in a number of cellular processes, including DNA repair, RNA transcription, signal transduction, protein compartmentalization, and possibly protein translation (Lee et al., 2005 [PubMed 16051612]).[supplied by OMIM, Mar 2008]

PRMT8 基因产物(9)

mRNA Protein Name
NM_001256536.1 NP_001243465.1 protein arginine N-methyltransferase 8 isoform 2
XM_047429157.1 XP_047285113.1 protein arginine N-methyltransferase 8 isoform X3
XM_047429159.1 XP_047285115.1 protein arginine N-methyltransferase 8 isoform X5
XM_017019644.2 XP_016875133.1 protein arginine N-methyltransferase 8 isoform X1
XM_017019645.1 XP_016875134.1 protein arginine N-methyltransferase 8 isoform X2
XM_047429158.1 XP_047285114.1 protein arginine N-methyltransferase 8 isoform X4
NM_001256537.1
NR_046301.1
NM_019854.5 NP_062828.3 protein arginine N-methyltransferase 8 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables S-adenosyl-L-methionine binding IDA
IDA: 通过直接分析推断
26876602 GOA
enables S-adenosylmethionine-dependent methyltransferase activity IDA
IDA: 通过直接分析推断
16051612 GOA
enables enzyme binding IDA
IDA: 通过直接分析推断
16051612 GOA
enables histone H4 methyltransferase activity IDA
IDA: 通过直接分析推断
16051612 GOA
enables identical protein binding IDA
IDA: 通过直接分析推断
26876602 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16051612 GOA
enables protein homodimerization activity IPI
IPI: 通过物理相互作用推断
16051612 GOA
enables protein-arginine omega-N asymmetric methyltransferase activity IDA
IDA: 通过直接分析推断
16051612 GOA
enables protein-arginine omega-N monomethyltransferase activity IDA
IDA: 通过直接分析推断
16051612 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in peptidyl-arginine methylation IDA
IDA: 通过直接分析推断
18320585 GOA
involved in protein homooligomerization IDA
IDA: 通过直接分析推断
26876602 GOA
involved in protein methylation IMP
IMP: 通过突变表型推断
26876602 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasmic side of plasma membrane IDA
IDA: 通过直接分析推断
26876602 GOA
NOT located in nucleus IDA
IDA: 通过直接分析推断
16051612 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
16051612 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PRMT8 蛋白结构

PrmA

PrmA: Ribosomal protein L11 methyltransferase (PrmA) (108 - 184)

  • 0
  • 100
  • 200
  • 300
  • 394 a.a.
蛋白主名 其他名称

protein arginine N-methyltransferase 8

HMT1 hnRNP methyltransferase-like 3

arginine methyltransferase 8

heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 4

protein arginine N-methyltransferase 4

PRMT8 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra PRMT8 Q9NR22 SYNCRIP Homo sapiens O60506
Y2H Array
19060904
Intra PRMT8 Q9NR22 SYNCRIP Homo sapiens O60506
Y2H
23455924
Intra PRMT8 Q9NR22 SYNCRIP Homo sapiens O60506
Anti Tag CoIP
33961781
Intra PRMT8 Q9NR22 SYNCRIP Homo sapiens O60506
Y2H Pooling
19060904
Intra PRMT8 Q9NR22 PRMT1 Homo sapiens Q99873-3
Y2H Array
32296183
Intra PRMT8 Q9NR22 PRMT1 Homo sapiens Q99873-3
Y2H Prey Pooling
32296183
Intra PRMT8 Q9NR22 PRMT1 Homo sapiens Q99873-3
MAPPIT
32296183
Intra PRMT8 Q9NR22 PRMT8 Homo sapiens Q9NR22
Y2H
23455924
Intra PRMT8 Q9NR22 PRMT8 Homo sapiens Q9NR22
Y2H Pooling
16189514
Intra PRMT8 Q9NR22 PRMT8 Homo sapiens Q9NR22
Y2H Prey Pooling
32296183
Intra PRMT8 Q9NR22 PRMT8 Homo sapiens Q9NR22
Y2H Array
19060904
Intra PRMT8 Q9NR22 PRMT8 Homo sapiens Q9NR22
Validated Y2H
32296183
Intra PRMT8 Q9NR22 PRMT8 Homo sapiens Q9NR22
Y2H Pooling
19060904
Intra PRMT8 Q9NR22 PRMT8 Homo sapiens Q9NR22
Y2H Array
32296183
Intra PRMT8 Q9NR22 PRMT1 Homo sapiens Q99873
Y2H
23455924
Intra PRMT8 Q9NR22 PRMT1 Homo sapiens Q99873
Anti Tag CoIP
33961781
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (8)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-19615 MS023 Inhibitor 99.73% 否
HY-12970A EPZ020411 hydrochloride Inhibitor 98.15% 否
HY-12970 EPZ020411 Inhibitor 98.06% 否
HY-19615B MS023 dihydrochloride Inhibitor 99.78% 否
HY-100360 MS049 Inhibitor ≥98.0% 否
HY-128717B GSK3368715 trihydrochloride Inhibitor / 否
HY-146810 PRMT4-IN-1 Inhibitor / 否
HY-161334 CARM1-IN-4 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus PRMT8 RGD RGD:1587677
Mus musculus PRMT8 MGD MGI:3043083
Felis catus PRMT8 VGNC VGNC:67652
Bos taurus PRMT8 VGNC VGNC:33353
Canis familiaris PRMT8 VGNC VGNC:45001
Macaca mulatta PRMT8 VGNC VGNC:76360
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