2. Gene
  3. PRMT1 - protein arginine methyltransferase 1 Gene

PRMT1 - protein arginine methyltransferase 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：蛋白质精氨酸甲基转移酶 1

种属: Homo sapiens

同用名: ANM1; HCP1; IR1B4; HRMT1L2

基因 ID: 3276 | 基因类型: protein coding

关于 PRMT1

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:49,676,153-49,688,447 (from NCBI)

This gene has 21 transcripts (splice variants), 206 orthologues and 7 paralogues. Ubiquitous expression in ovary (RPKM 42.8), heart (RPKM 38.0) and 25 other tissues.

功能概要

该基因编码蛋白质精氨酸 N-甲基转移酶 (PRMT) 家族的成员。 PRMTs 对目标蛋白的翻译后修饰在许多生物过程中起着重要的调节作用，PRMTs 通过将甲基从 S-腺苷-L-甲硫氨酸转移到末端胍基氮原子来甲基化精氨酸残基。编码的蛋白质是 I 型 PRMT，负责大部分细胞精氨酸甲基化活性。该基因表达增加可能在许多类型的癌症中发挥作用。已经观察到该基因编码多种亚型的选择性剪接转录变体，并且该基因的假基因位于 5 号染色体的长臂上。[RefSeq 提供，2011 年 12 月]

This gene encodes a member of the protein arginine N-methyltransferase (PRMT) family. Post-translational modification of target proteins by PRMTs plays an important regulatory role in many biological processes, whereby PRMTs methylate arginine residues by transferring methyl groups from S-adenosyl-L-methionine to terminal guanidino nitrogen atoms. The encoded protein is a type I PRMT and is responsible for the majority of cellular arginine methylation activity. Increased expression of this gene may play a role in many types of Cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2011]

PRMT1 基因产物(9)

mRNA Protein Name
XM_047438742.1 XP_047294698.1 protein arginine N-methyltransferase 1 isoform X1
NR_033397.5
NM_198319.2
XM_017026735.2 XP_016882224.1 protein arginine N-methyltransferase 1 isoform X2
XM_017026736.2 XP_016882225.1 protein arginine N-methyltransferase 1 isoform X3
NM_001207042.3 NP_001193971.1 protein arginine N-methyltransferase 1 isoform 4
NM_001536.6 NP_001527.3 protein arginine N-methyltransferase 1 isoform 1
XM_047438743.1 XP_047294699.1 protein arginine N-methyltransferase 1 isoform X1
NM_198318.5 NP_938074.2 protein arginine N-methyltransferase 1 isoform 3

PRMT1 蛋白结构

Methyltransf_31

Methyltransf_31: Methyltransferase domain (88 - 162)

  • 0
  • 100
  • 200
  • 300
  • 371 a.a.
蛋白主名 其他名称

protein arginine N-methyltransferase 1

HMT1 (hnRNP methyltransferase, S. cerevisiae)-like 2

heterogeneous nuclear ribonucleoprotein methyltransferase 1-like 2

highly conserved protein 1

histone-arginine N-methyltransferase PRMT1

interferon receptor 1-bound protein 4

关联疾病

疾病名称 别名
Ewing Sarcoma

Neuroepithelioma

Ewing'S Tumor

Ewings Sarcoma

Ewing'S Sarcoma

Peripheral Neuroepithelioma

Primitive Neuroectodermal Tumor

ES

Ewings Sarcoma-Primitive Neuroectodermal Tumor

Localized Peripheral Primitive Neuroectodermal Tumor

Peripheral Primitive Neuroectodermal Tumor

Ewing Tumor

Sarcoma, Ewing'S

Extraosseous Ewing Tumor

Askin Tumor

Ewing'S Family Localized Tumor

Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor

Localized Ewing Sarcoma

Localized Ewing'S Sarcoma

Localized Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor

Localized Ewing'S Tumor

Pnet Of Thoracopulmonary Region

Ewing Family Of Tumors

Tumor Of The Ewing Family

Skeletal Ewing Sarcoma

Osseous Ewing Sarcoma

Ppnet

Peripheral Pnet

Extraskeletal Ewing Sarcoma

Eoe

Extraosseous Ewing Sarcoma

Extraskeletal Ewing Tumor

Esft

Ewing Sarcoma Family Of Tumors

Pne

Pnet

Pnet Of The Chest Wall

Sarcoma, Ewing

Neuroectodermal Tumors, Primitive, Peripheral

Neuroectodermal Tumor, Primitive

Disorder Of Eye

Askin'S Tumor

Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor

Neuroepithelioma, Peripheral
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Spinal Cord Primitive Neuroectodermal Neoplasm

Spinal Cord Pnet

Spinal Cord Primitive Neuroectodermal Tumor
Encephalopathy, Neonatal Severe, Due To Mecp2 Mutations

Severe Congenital Encephalopathy Due To Mecp2 Mutation

Severe Neonatal-Onset Encephalopathy With Microcephaly

Encephalopathy, Neonatal Severe

Neonatal Severe Encephalopathy Due To Mecp2 Mutations

Mecp2-Related Severe Neonatal Encephalopathy

Methyl-Cytosine Phosphate Guanine Binding Protein 2 Related Severe Neonatal Encephalopathy

Severe Neonatal Encephalopathy Due To Mecp2 Mutations

ENS-MECP2

Encephalopathy, Neonatal, Severe
Spinal Cord Neuroblastoma

Neuroblastoma Of The Spinal Cord
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (14)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-19615 MS023 Inhibitor 99.73% 否
HY-18962 AMI-1 Inhibitor ≥98.0% 否
HY-12970A EPZ020411 hydrochloride Inhibitor 98.15% 否
HY-12970 EPZ020411 Inhibitor 98.06% 否
HY-107574 TC-E 5003 Inhibitor 98.03% 否
HY-110137 Furamidine dihydrochloride Inhibitor ≥99.0% 否
HY-19615B MS023 dihydrochloride Inhibitor 99.78% 否
HY-122096 DCLX069 Inhibitor 98.03% 否
HY-128717B GSK3368715 trihydrochloride Inhibitor / 否
HY-161334 CARM1-IN-4 Inhibitor / 否
HY-146810 PRMT4-IN-1 Inhibitor / 否
HY-149005 PRMT5-IN-19 Inhibitor / 否
HY-162230 PRMT5-IN-33 Inhibitor / 否
HY-164456 AMI-408 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus PRMT1 VGNC VGNC:103742
Macaca mulatta PRMT1 VGNC VGNC:97809
Canis familiaris PRMT1 VGNC VGNC:44995
Mus musculus PRMT1 MGD MGI:107846
Bos taurus PRMT1 VGNC VGNC:52239
Rattus norvegicus PRMT1 RGD RGD:62020
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