2. Gene
  3. HNRNPR - heterogeneous nuclear ribonucleoprotein R Gene

HNRNPR - heterogeneous nuclear ribonucleoprotein R Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：异质核核糖核蛋白 R

种属: Homo sapiens

同用名: HNRPR; NEDDFSB; hnRNP-R

基因 ID: 10236 | 基因类型: protein coding

关于 HNRNPR

Cytogenetic location: 1p36.12 Genomic coordinates (GRCh38): 1:23,304,688-23,344,284 (from NCBI)

This gene has 14 transcripts (splice variants), 1 gene allele, 236 orthologues, 24 paralogues and is associated with 1 phenotype. Ubiquitous expression in lymph node (RPKM 17.7), appendix (RPKM 17.6) and 25 other tissues.

功能概要

该基因编码一种 RNA 结合蛋白，它是剪接体 C 复合体的成员，在 pre-mRNA 加工和运输中发挥作用。编码的蛋白质还促进 c-Fos 基因的转录。可变剪接导致多个转录本变体。该基因在 4、11 和 10 号染色体上存在假基因。[RefSeq 提供，2014 年 7 月]

This gene encodes an RNA-binding protein that is a member of the spliceosome C complex, which functions in pre-mRNA processing and transport. The encoded protein also promotes transcription at the c-Fos gene. Alternative splicing results in multiple transcript variants. There are pseudogenes for this gene on chromosomes 4, 11, and 10. [provided by RefSeq, Jul 2014]

HNRNPR 基因产物(7)

mRNA Protein Name
NM_001102397.3 NP_001095867.1 heterogeneous nuclear ribonucleoprotein R isoform 4
NM_001102398.3 NP_001095868.1 heterogeneous nuclear ribonucleoprotein R isoform 1
NM_001102399.3 NP_001095869.1 heterogeneous nuclear ribonucleoprotein R isoform 3
NM_001297620.2 NP_001284549.1 heterogeneous nuclear ribonucleoprotein R isoform 5
NM_001297621.2 NP_001284550.1 heterogeneous nuclear ribonucleoprotein R isoform 7
NM_001297622.2 NP_001284551.1 heterogeneous nuclear ribonucleoprotein R isoform 6
NM_005826.5 NP_005817.1 heterogeneous nuclear ribonucleoprotein R isoform 2
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16169070 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of catalytic step 2 spliceosome IDA
IDA: 通过直接分析推断
11991638 GOA
NOT located in nucleolus IDA
IDA: 通过直接分析推断
9421497 GOA
located in nucleoplasm IDA
IDA: 通过直接分析推断
9421497 GOA
located in nucleus IDA
IDA: 通过直接分析推断
31079900 GOA
part of ribonucleoprotein complex IDA
IDA: 通过直接分析推断
17289661 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

HNRNPR 蛋白结构

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (167 - 231)

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (248 - 309)

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (343 - 404)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 633 a.a.
蛋白主名 其他名称

heterogeneous nuclear ribonucleoprotein R

HNRNPR 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
HNRNPR O43390 NCK1 Homo sapiens P16333
Peptide Array
17474147
种属内
HNRNPR O43390 KHDRBS2 Homo sapiens Q5VWX1
Y2H Prey Pooling
25416956
种属内
HNRNPR O43390 KHDRBS2 Homo sapiens Q5VWX1
Validated Y2H
25416956
种属内
HNRNPR O43390 PRMT1 Homo sapiens Q99873
Y2H Prey Pooling
25416956
种属内
HNRNPR O43390 PRMT1 Homo sapiens Q99873
Y2H Pooling
16169070
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 HNRNPR 蛋白

目录号 产品名 蛋白编号 纯度
HY-P73920 HNRNPR Protein, Human (sf9, His-GST) O43390-2 (A2-K636) ≥95%

关联疾病

疾病名称 别名
Neurodevelopmental Disorder With Dysmorphic Facies And Skeletal And Brain Abnormalities

NEDDFSB
Spinal Muscular Atrophy

Sma

5q Sma

Proximal Sma

Sma-Associated Sma

Spinal Amyotrophies

Spinal Amyotrophy

Spinal Muscle Degeneration

Spinal Muscle Wasting

Muscular Atrophy Spinal

Atrophy, Muscular, Spinal

Hereditary Motor Neuronopathy

Progressive Muscular Atrophy

Sma - [Spinal Muscular Atrophy]
Muscular Atrophy

Muscle Wasting

Amyotrophia

Wasting - Muscle

Skeletal Muscle Atrophy
Spinal Muscular Atrophy, Type Iii

SMA3

Juvenile Spinal Muscular Atrophy

Kugelberg-Welander Disease

Sma Iii

Kugelberg-Welander Syndrome

Kws

Muscular Atrophy, Juvenile

Spinal Muscular Atrophy, Mild Childhood And Adolescent Form

Spinal Muscular Atrophy-3

Spinal Muscular Atrophy Type 3

Spinal Muscular Atrophy, Type Iii, Modifier Of

Type Iii Spinal Muscular Atrophy

Sma 3

Proximal Spinal Muscular Atrophy Type 3

Sma Type 3

Sma Type Iii

Sma-Iii

Spinal Muscular Atrophy 3

Spinal Muscular Atrophy Mild Childhood And Adolescent Form

Spinal Muscular Atrophy Type Iii

Wohlfart-Kugelberg-Welander Disease

Atrophy, Muscular, Spinal, Type Iii
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06277 HNRNPR Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus HNRNPR RGD RGD:631348
Felis catus HNRNPR VGNC VGNC:67612
Mus musculus HNRNPR MGD MGI:1891692
Canis familiaris HNRNPR VGNC VGNC:41735
Bos taurus HNRNPR VGNC VGNC:29899
Macaca mulatta HNRNPR VGNC VGNC:73499
Others HNRNPR NCBI
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