NR4A1 - nuclear receptor subfamily 4 group A member 1 Gene

中文名称：核受体亚家族 4 A 组成员 1

种属: Homo sapiens

同用名: HMR; N10; TR3; NP10; GFRP1; NAK-1; NGFIB; NUR77

基因 ID: 3164 | 基因类型: protein coding

关于 NR4A1

Cytogenetic location: 12q13.13 Genomic coordinates (GRCh38): 12:52,022,832-52,059,503 (from NCBI)

This gene has 22 transcripts (splice variants), 268 orthologues and 2 paralogues. Broad expression in adrenal (RPKM 103.3), ovary (RPKM 73.7) and 19 other tissues.

功能概要

该基因编码类固醇-甲状腺激素-类视黄醇受体超家族的成员。表达由人淋巴细胞中的植物血凝素和停滞的成纤维细胞的血清刺激诱导。编码的蛋白质充当核转录因子。蛋白质从细胞核转移到线粒体会诱导细胞凋亡。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供，2011 年 1 月]

This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces Apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

NR4A1 基因产物(4)

mRNA	Protein	Name
NM_001202233.2	NP_001189162.1	nuclear receptor subfamily 4 group A member 1 isoform 2
NM_001202234.2	NP_001189163.1	nuclear receptor subfamily 4 group A member 1 isoform 3
NM_002135.5	NP_002126.2	nuclear receptor subfamily 4 group A member 1 isoform 1
NM_173157.3	NP_775180.1	nuclear receptor subfamily 4 group A member 1 isoform 1

NR4A1 蛋白结构

zf-C4

Hormone_recep

0
100
200
300
400
500
598 a.a.

蛋白主名

其他名称

nuclear receptor subfamily 4 group A member 1

ST-59

关联疾病

疾病名称

别名

Pseudohypoaldosteronism

Pyomyositis

Tropical Pyomyositis	Myositis Tropicans
Myositis Purulenta Tropica	Pm
Suppurative Myositis	Purulent Myositis

Adrenal Cortical Carcinoma

Adrenocortical Carcinoma	Adrenal Cortex Carcinoma
Carcinoma Of The Adrenal Cortex	Acc
Adrenocortical Cancer	Carcinoma Adrenocortical

46,Xy Sex Reversal 2

Dosage-Sensitive Sex Reversal	Dss
SRXY2	46,Xy Sex Reversal, Dax1-Related
46xy Sex Reversal 2, Dosage-Sensitive	46,Xy Sex Reversal Dax1-Related

Night Blindness, Congenital Stationary, Type 1h

Congenital Stationary Night Blindness 1h	CSNB1H
Congenital Stationary Night Blindness Type 1h	Night Blindness, Congenital Stationary, 1h

46,Xy Sex Reversal

Swyer Syndrome	Pure Gonadal Dysgenesis 46,Xy
Gonadal Dysgenesis, Xy Female Type	Gonadal Dysgenesis, 46,Xy
46,Xy Cgd	46,Xy Complete Gonadal Dysgenesis
46,Xy Pure Gonadal Dysgenesis	46 Xy Gonadal Dysgenesis
46, Xy Cgd	46, Xy Complete Gonadal Dysgenesis
46, Xy Pure Gonadal Dysgenesis	Xy Pure Gonadal Dysgenesis
Female With 46,Xy Karyotype	Xy Females

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Rhabdomyosarcoma

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Alzheimer Disease, Familial, 1

Alzheimer Disease	Alzheimer'S Disease
Presenile And Senile Dementia	AD1
Alzheimer Disease, Susceptibility To	Alzheimer Disease, Late-Onset, Susceptibility To
Alzheimer Disease 1, Familial	AD
Familial Alzheimer Disease	Alzheimer Disease, Late-Onset
Alzheimers Dementia	Alzheimer Dementia
Alzheimer Sclerosis	Alzheimer Syndrome
Alzheimer-Type Dementia	Dat
Primary Senile Degenerative Dementia	Sdat
Alzheimer Disease 1	Autosomal Dominant Alzheimer Disease
Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy	Late Onset Alzheimer Disease
Alzheimers Disease	Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy
Late-Onset Alzheimers Disease	Alzheimer'S Disease Pathway Kegg
Dementia Due To Alzheimer'S Disease	Alzheimer Disease Type 1
Alzheimers

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

目录号	产品名	作用方式	纯度	是否罕见病
HY-P1624	Teduglutide	Activator	99.94%	否
HY-P1624A	Teduglutide TFA	Activator	/	否

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-N2148	Cytosporone B	Agonist	98.63%	否
HY-112055	DIM-C-pPhOH		99.05%	否
HY-112056	DIM-C-pPhCO2Me	Antagonist	99.47%	否
HY-RS09550	NR4A1 Human Pre-designed siRNA Set A		/	否
HY-160498	Amoitone B	Agonist	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	NR4A1	VGNC	VGNC:32245
Canis familiaris	NR4A1	VGNC	VGNC:43954
Mus musculus	NR4A1	MGD	MGI:1352454
Rattus norvegicus	NR4A1	RGD	RGD:620029
Felis catus	NR4A1	VGNC	VGNC:68554
Macaca mulatta	NR4A1	VGNC	VGNC:75517

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