2. Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease
  3. Nuclear Hormone Receptor 4A/NR4A FXR
  4. Teduglutide TFA

Teduglutide TFA  (Synonyms: ALX-0600 TFA)

目录号: HY-P1624A
产品使用指南

摩尔计算器

Teduglutide TFA 是一种二肽基肽酶 IV 耐药胰高血糖素样肽 2 (GLP-2) 类似物。Teduglutide TFA 可以激活人肝星状细胞中的核受体亚家族 4 组 a 成员 1 (NR4a1)/nur77 表达和肠道 FXR 信号传导，从而改善硬化性胆管炎小鼠的肝脏炎症和纤维化。Teduglutide TFA 可以缓解小鼠的肠功能不全，改善肺损伤，改善肥胖相关神经炎症和细胞凋亡 (apoptosis)。

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Custom Peptide Synthesis

Teduglutide TFA Chemical Structure

Teduglutide TFA Chemical Structure

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Teduglutide TFA 的其他形式现货产品:

Customer Review

Other Forms of Teduglutide TFA:

Teduglutide TFA 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

查看 Nuclear Hormone Receptor 4A/NR4A 亚型特异性产品:

查看所有亚型
Nurr1/NR4A2 Nur77/NR4A1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Teduglutide TFA is a dipeptidyl peptidase IV resistant glucagon-like peptide 2 (GLP-2) analogue. Teduglutide TFA can activate the expression of nuclear receptor subfamily 4 group a member 1 (NR4a1)/nur77 and intestinal FXR signaling in human hepatic stellate cells, thereby improving liver inflammation and fibrosis in mice with sclerosing cholangitis. Teduglutide TFA can alleviate intestinal dysfunction in mice, improve lung injury, alleviate obesity related neuroinflammation and cell apoptosis[1][2][3][4].
体外研究
(In Vitro)

Teduglutide (2.5 μM, 36 h) TFA 可以激活人肝星状细胞中的核受体亚家族 4 组 a 成员 1 (NR4a1)/nur77 表达[4]。
Teduglutide TFA 可以增加短肠新生仔猪模型中所有肠段上皮细胞的增殖并减少细胞凋亡[5]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Teduglutide TFA 相关抗体:

Real Time qPCR[4].

Cell Line: Human Hepatic Stellate Cells (HSC)
Concentration: 2.5 μM
Incubation Time: 36 h
Result: Increased transcription levels of NR4a1/Nur77.
体内研究
(In Vivo)

Teduglutide (0.1 mg/kg; 每天 2 次; 2 周; 皮下注射) TFA 可以缓解盲肠切除小鼠的肠功能不全和核苷酸寡聚结构域 2 (Nod2) 功能障碍引起的的肠衰竭[1]。
Teduglutide (200 μg/kg; 每天 2 次; 10 天; 皮下注射) TFA 对肺损伤小鼠具有抗凋亡和抗氧化活性[2]。
Teduglutide (5 μg; 每天 1 次; 4 周; 腹腔注射) TFA 可以改善高脂饮食喂养小鼠的肥胖相关的神经炎症、中枢应激状况和细胞凋亡[3]。
Teduglutide (0.05 mg/kg; 每天 1 次; 4 周; 腹腔注射) TFA 通过激活肝星状细胞中的 NR4a1/nur77 和肠道 FXR 信号传导来改善硬化性胆管炎 Mdr2 小鼠模型中的肝脏炎症和纤维化[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male mice undergoing 12-cm ileocecal and cecal resection (ICR)[1].
Dosage: 0.1 mg/kg
Administration: Subcutaneous injection (s.c.); twice daily; 2 weeks
Result: Resulted in a decrease in plasma aldosterone concentration, a decrease in fecal water content, and a decrease in fecal sodium loss.
Animal Model: A mouse model with lung injury induced by tumor necrosis factor-alpha (TNF-α) and actinomycin D (Act D)[2].
Dosage: 200 μg/kg
Administration: Subcutaneous injection (s.c.); twice daily; 10 days
Result: Attenuated structural damage, cell apoptosis, and oxidative stress by reducing lipid peroxidation in mice receiving TNF - α/AtD.
Animal Model: Mice fed a high-fat diet (HFD)[3].
Dosage: 5 μg
Administration: Intraperitoneal injection (i.p.); once daily; 4 weeks
Result: Reduced the expression of HFD induced pro-inflammatory mediators (NF kB, IL-8, TNF - α, IL-1 β, and IL-6), glial fibrillary acidic protein (GFAP), glial proliferation and neurodegeneration index, stress marker proteins (p-ERK, Hsp60, and i-NOS), and amyloid beta precursor protein (APP).
Animal Model: The Mdr2/Abcb4 mouse model of sclerosing cholangitis displaying hepatic inflammation and fibrosis[4].
Dosage: 0.05 mg/kg
Administration: Intraperitoneal injection (i.p.); once daily; 4 weeks
Result: Resulted in an increase in intrahepatic level of muricholic acids and serum Fgf15 level, as well as a decrease in mRNA levels of Cyp7a1 and FXR.
Clinical Trial
分子量

3752.13 (free acid)

Formula

C164H252N44O55S.xC2HF3O2
Sequence Shortening

HGDGSFSDEMNTILDNLAARDFINWLIQTKITD
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Teduglutide TFA 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TeduglutideALX-0600ALX0600ALX 0600Nuclear Hormone Receptor 4A/NR4AFXRNerve Growth Factor IB-like ReceptorNR1H4HSCintestinal functionlung injuryobesityInhibitorinhibitorinhibit

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