Tauro-β-muricholic acid sodium  (Synonyms: T-βMCA sodium)

Tauro-β-muricholic Acid sodium (T-βMCA sodium), a endogenous metabolite, is a competitive and reversible farnesoid X receptor (FXR) antagonist, with an IC₅₀ of 40 μM^[1][2][3].

IC50: 40 μM (FXR)^[1]

T-βMCA sodium inhibits FXR reporter activity in the CRC cell line HT29 (EC₅₀ ~10 μM)^[3].
T-βMCA sodium dose-dependently increases WNT signaling in HT29 and HCT116 cells^[3].
T-βMCA sodium induces proliferation and DNA damage in Lgr5⁺ cells^[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

T-βMCA sodium (400 mg/kg; i.g.; twice a week; for 6 weeks) can effectively recapitulate the ability of HFD to promote CRC progression^[3].
T-βMCA sodium treatment also significantly increases levels of serum cytokines, including IFN-γ, IL-6, and IL-17^[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

537.68

C₂₆H₄₄NNaO₇S

145022-92-0

固体

White to off-white

Room temperature in continental US; may vary elsewhere.

-20°C, stored under nitrogen, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

• [1]. Sayin SI, et al. Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist. Cell Metab. 2013 Feb 5;17(2):225-35.  [Content Brief]

  [2]. Wahlström A, et al. Induction of farnesoid X receptor signaling in germ-free mice colonized with a human microbiota. J Lipid Res. 2017 Feb;58(2):412-419.  [Content Brief]

  [3]. Fu T, et al. FXR Regulates Intestinal Cancer Stem Cell Proliferation. Cell. 2019 Feb 21;176(5):1098-1112.e18.  [Content Brief]