1. Gene
  2. XPO1 - exportin 1 Gene

XPO1 - exportin 1 Gene

中文名称:输出 1

种属: Homo sapiens

同用名: emb; CRM1; exp1; CRM-1

基因 ID: 7514 | 基因类型: protein coding

关于 XPO1

Cytogenetic location: 2p15 Genomic coordinates (GRCh38): 2:61,477,849-61,538,612 (from NCBI)

This gene has 55 transcripts (splice variants), 229 orthologues, 1 paralogue and is associated with 91 phenotypes. Ubiquitous expression in testis (RPKM 38.6), lymph node (RPKM 33.8) and 25 other tissues.

功能概要

这种细胞周期调节基因编码一种介导富含亮氨酸的核输出信号 (NES) 依赖性蛋白质转运的蛋白质。该蛋白特异性抑制 Rev 和 U snRNA 的核输出。它通过控制细胞周期蛋白 B、MPAK 和 MAPKAP 激酶 2 的定位参与多个细胞过程的控制。该蛋白还调节 NFAT 和 AP-1。[RefSeq 提供,2015 年 1 月]

This cell-cycle-regulated gene encodes a protein that mediates leucine-rich nuclear export signal (NES)-dependent protein transport. The protein specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. This protein also regulates NFAT and AP-1. [provided by RefSeq, Jan 2015]

XPO1 基因产物(2)

mRNA Protein Name
NM_001410799.1 NP_001397728.1 exportin-1 isoform 2
NM_003400.4 NP_003391.1 exportin-1 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables nuclear export signal receptor activity IDA
IDA: 通过直接分析推断
29666234 GOA
enables nuclear export signal receptor activity IMP
IMP: 通过突变表型推断
12724356 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
10358091 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in nucleocytoplasmic transport IMP
IMP: 通过突变表型推断
11000203 GOA
involved in protein export from nucleus IDA
IDA: 通过直接分析推断
22250199 GOA
acts upstream of or within protein export from nucleus IMP
IMP: 通过突变表型推断
22427340 GOA
involved in protein export from nucleus IMP
IMP: 通过突变表型推断
12773398 GOA
involved in protein export from nucleus IPI
IPI: 通过物理相互作用推断
29666234 GOA
involved in regulation of proteasomal ubiquitin-dependent protein catabolic process IDA
IDA: 通过直接分析推断
29666234 GOA
involved in ribosomal large subunit export from nucleus IMP
IMP: 通过突变表型推断
12773398 GOA
involved in ribosomal small subunit export from nucleus IMP
IMP: 通过突变表型推断
12773398 GOA
involved in ribosomal subunit export from nucleus IMP
IMP: 通过突变表型推断
12724356 GOA
involved in ribosome biogenesis IMP
IMP: 通过突变表型推断
12724356 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in annulate lamellae IDA
IDA: 通过直接分析推断
12210765 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
23782956 GOA
located in kinetochore IDA
IDA: 通过直接分析推断
17363900 GOA
located in nucleolus IDA
IDA: 通过直接分析推断
23782956 GOA
part of protein-containing complex IDA
IDA: 通过直接分析推断
10557333 GOA
part of ribonucleoprotein complex IDA
IDA: 通过直接分析推断
18809582 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

XPO1 蛋白结构

IBN_N

IBN_N: Importin-beta N-terminal domain (46 - 111)

Xpo1

Xpo1: Exportin 1-like protein (124 - 268)

CRM1_C

CRM1_C: CRM1 C terminal (709 - 1027)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1071 a.a.
蛋白主名 其他名称

exportin-1

chromosome region maintenance 1 homolog

XPO1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
XPO1 O14980 YWHAZ Homo sapiens P63104
Pull Down
15161933
种属内
XPO1 O14980 DHX9 Homo sapiens Q08211
Anti Bait CoIP
19955415
种属内
XPO1 O14980 PHB1 Homo sapiens P35232
Anti Bait CoIP
16319068
种属内
XPO1 O14980 TP53 Homo sapiens P04637
Anti Bait CoIP
17268548
种属内
XPO1 O14980 TP53 Homo sapiens P04637
Anti Bait CoIP
18952844
种属内
XPO1 O14980 BIRC5 Homo sapiens O15392
Pull Down
17099693
种属内
XPO1 O14980 SNUPN Homo sapiens O95149
ITC
19339969
种属内
XPO1 O14980 SNUPN Homo sapiens O95149
X-Ray Diffraction
19339969
种属内
XPO1 O14980 SNUPN Homo sapiens O95149
Pull Down
19339969
种属内
XPO1 O14980 SNUPN Homo sapiens O95149
SAXS
23850451
种属内
XPO1 O14980 SNUPN Homo sapiens O95149
GMS
19339969
种属内
XPO1 O14980 SNUPN Homo sapiens O95149
Pull Down
19339972
种属内
XPO1 O14980 RCC1 Homo sapiens P18754
Anti Tag CoIP
35271311
种属间
XPO1 O14980 rev Human immunodeficiency virus P04618
Pull Down
19339969
种属间
XPO1 O14980 rev Human immunodeficiency virus P04618
Pull Down
19339972
种属间: 跨种属相互作用 种属内: 同种属相互作用

XPO1 抗体

目录号 产品名 应用 反应物种
HY-P81809 CRM1 Antibody (YA1554) WB, IHC-P, ICC/IF, FC Human, Mouse, Rat

关联疾病

疾病名称 别名
Primary Mediastinal Large B-Cell Lymphoma

Mediastinal Large B-Cell Lymphoma

Large Cell Lymphoma Of The Mediastinum

Med-Dlbcl

Mediastinal Diffuse Large-Cell Lymphoma With Sclerosis

Primary Mediastinal Clear Cell Lymphoma Of B-Cell Type

Mediastinal Large B-Cell Lymphoma

Influenza

Flu

Influenza With Non-Respiratory Manifestation

Influenza With Other Manifestations

Influenza, Human

Influenza, Susceptibility To

Seasonal Influenza, Virus Identified

Venezuelan Equine Encephalitis

Venezuelan Equine Fever

Venezuelan Equine Encephalomyelitis

Encephalitis Venezuelan Equine

Encephalomyelitis, Venezuelan Equine

Venezuelan Encephalitis

Disorder Due To Venezuelan Equine Encephalitis Virus

Venezuelan Equine Encephalitis Virus Infection

Venezuelan Equine Encephalomyelitis Virus Disease

Suppression Of Tumorigenicity 12

Prostate Adenocarcinoma

Adenocarcinoma Of Prostate

ST12

Prostate Adenocarcinoma 1

Pac1

Encephalitis

Mumps Encephalitis

Mumps Meningoencephalitis

Herpes Simplex Neuroinvasion

Herpetic Encephalitis

Herpetic Encephalopathy

Herpes Simplex Encephalitis, Myelitis Or Encephalomyelitis

Encephalitis Due To Herpesviridae

Encephalitis Due To Herpesvirus

Herpes Encephalitis

Herpesviral Encephalitis

Herpes Simplex Encephalitis

Hsv - [Herpes Simplex Virus] Encephalitis

Herpes Virus Encephalitis

Simian B Disease

Simian B Disorder

Encephalitis Nec

Idiopathic Encephalitis

Leukemia, Chronic Lymphocytic

Chronic Lymphocytic Leukemia

B-Cell Chronic Lymphocytic Leukemia

CLL

B-Cell Chronic Lymphoid Leukemia

Chronic Lymphatic Leukemia

Chronic Lymphocytic Leukaemia

Lymphoplasmacytic Leukemia

Small Lymphocytic Lymphoma

Leukemia, Chronic Lymphatic

B-Cell Chronic Lymphocytic Leukaemia

Chronic Lymphatic Leukaemia

Lymphoplasmacytic Leukaemia

B Cell Chronic Lymphocytic Leukemia

Chronic B-Cell Lymphocytic Leukemia

Leukemia, Lymphocytic, Chronic

B-Cll

Chronic Lymphoid Leukemia

Leukemia Lymphocytic Chronic

Lymphoma Small Lymphocytic

Leukemia, Lymphocytic, Chronic, B-Cell

Mediastinal Gray Zone Lymphoma

Mediastinal B-Cell Lymphoma, Unclassifiable, With Features Intermediate Between Diffuse Large B-Cell Lymphoma And Classical Hodgkin Lymphoma

Mediastinal Malignant Lymphoma

Lymphoma Of Mediastinum

Mediastinal Lymphoma

T-Cell Acute Lymphoblastic Leukemia

T-Cell Leukemia

Acute T Cell Leukemia

Precursor T Lymphoblastic Leukemia

Precursor T-Lymphoblastic Lymphoma/Leukemia

T Acute Lymphoblastic Leukemia

T-Cell Acute Lymphocytic Leukaemia

T-Cell Lymphoblastic Leukemia/Lymphoma

Leukemia T-Cell

Leukemia, T-Cell

Leukemia, Acute, Lymphoblastic, T-Cell

Leukemia, T-Cell Acute Lymphoblastic

Leukemia, Acute T-Cell

Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

Precursor T-Cell Lymphoblastic Lymphoma

Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma

Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

Chromosome 2p16.1-P15 Deletion Syndrome

2p15p16.1 Microdeletion Syndrome

2p15-P16.1 Microdeletion Syndrome

Del(2)(P15p16.1)

Monosomy 2p15p16.1

Monosomy 2p15-P16.1

Relapsed/Refractory Diffuse Large B-Cell Lymphoma
Primary Mediastinal B-Cell Lymphoma

Large Cell Lymphoma Of The Mediastinum

Mediastinal Diffuse Large-Cell Lymphoma With Sclerosis

Primary Mediastinal Clear Cell Lymphoma Of B-Cell Type

Immune Deficiency Disease

Immunodeficiency

Primary Immunodeficiency

Primary Immunodeficiency Disease

Immunologic Deficiency Syndromes

Hypoimmunity

Immune Deficiency Disorder

Immunodeficiency Syndrome

Immune Disorder

Primary Immune Deficiency Disorder

Immune System Diseases

Human Immunodeficiency Virus Infection

Hiv - [Human Immunodeficiency Virus Infection]

Hiv Positive Nos

Hiv Disease

Acquired Immune Deficiency Syndrome-Related Complex

Aids-Like Syndrome

Aids-Related Complex Nos

Arc - [Aids-Related Complex]

Immunodeficiency Due To Human Immunodeficiency Virus Infection

Unspecified Human Immunodeficiency Virus Disease

Hiv Disease Nos

Human Immunodeficiency Virus Positive Nos

Hiv Nos

Deficiency Of Complement Initial Pathway

Deficiency Of Complement Terminal Pathway

Cfdd - [Complement Factor D Deficiency]

Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency

Nonfamilial Hypogammaglobulinaemia

Common Variable Immune Deficiency

Nonfamilial Agammaglobulinaemia

Common Variable Agammaglobulinaemia

Agammaglobulinaemia Nos

Agammaglobulinaemia Antibody Deficiency Syndrome

Hypogammaglobulinaemia Antibody Deficiency Syndrome

Acquired Agammaglobulinaemia Nos

Hypogammaglobulinaemia Nos

Hyper Igm

Peroxisome Biogenesis Disorder 11a

PBD11A

Peroxisome Biogenesis Disorder Complementation Group 13

PBD-CG13

Cg13

Pbd-Cgh

Peroxisome Biogenesis Disorder Complementation Group H

Peroxisome Biogenesis Disorder, Type 11a

Peroxisome Biogenesis Disorder, Complementation Group 13

Retinitis Pigmentosa 61

RP61

Retinitis Pigmentosa, Type 61

Mantle Cell Lymphoma

Lymphoma, Mantle Cell

Lcm

Mcl

Mantle Zone Lymphoma

Lymphoma Mantle-Cell

Lymphoma, Mantle-Cell

Malignant Lymphoma, Lymphocytic, Intermediate Differentiation, Diffuse

Malignant Lymphoma - Lymphocytic, Intermediate Differentiation

Diffuse Small Cleaved-Cell Lymphoma

Diffuse Small Cleaved Cell Malignant Lymphoma

Small Cleaved Cell Non-Hodgkin Lymphoma

Diffuse Non-Hodgkin Small Cleaved Cell Lymphoma

Malignant Lymphomatous Polyposis

Malignant Small Cell, Noncleaved, Diffuse Lymphoma

Malignant Undifferentiated Cell, Non-Burkitt Lymphoma

Cleaved Cell Lymphoma

Small Cell Mantle Cell Lymphoma

Small Cleaved Cell Malignant Lymphoma

Leukemia, Acute Myeloid

Acute Myeloid Leukemia

Leukemia, Acute Myelogenous

Acute Myelogenous Leukemia

AML

Leukemia, Acute Myeloid, Susceptibility To

Acute Myeloblastic Leukemia

Leukemia, Acute Myeloid, Reduced Survival In, Somatic

Acute Myeloid Leukaemia

Leukemia, Myelocytic, Acute

Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

Secondary Aml

Acute Myelocytic Leukemia

Acute Myeloid Leukemia, Somatic

Leukemia, Acute Myeloid, Somatic

Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

Acute Myeloblastic Leukaemia

Acute Myelogenous Leukaemia

Aml - Acute Myeloid Leukemia

Acute Myeloid Leukemia With Cebpa Somatic Mutations

Aml With Cebpa Somatic Mutations

Inherited Acute Myeloid Leukemia

Familial Aml

Inherited Aml

Pure Familial Aml

Pure Familial Acute Myeloid Leukemia

Secondary Acute Myeloid Leukemia

Therapy-Related Aml And Myelodysplastic Syndrome

Acute Myeloid Leukemia, Secondary

Acute Non-Lymphoblastic Leukemia

Acute Non-Lymphocytic Leukemia

Acute Biphenotypic Leukemia

Acute Undifferentiated Leukemia

Acute Myeloblastic Leukaemia With Multilineage Dysplasia

Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

Acute Myeloid Leukaemia With Myelodysplasia-Related Features

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus XPO1 RGD RGD:620517
Felis catus XPO1 VGNC VGNC:81260
Mus musculus XPO1 MGD MGI:2144013
Bos taurus XPO1 VGNC VGNC:36997
Macaca mulatta XPO1 VGNC VGNC:78812
Canis familiaris XPO1 VGNC VGNC:48460