RCC1 - regulator of chromosome condensation 1 Gene

中文名称：染色体凝缩调节因子 1

种属: Homo sapiens

同用名: CHC1; RCC1-I

基因 ID: 1104 | 基因类型: protein coding

关于 RCC1

Cytogenetic location: 1p35.3 Genomic coordinates (GRCh38): 1:28,506,043-28,538,989 (from NCBI)

This gene has 14 transcripts (splice variants), 218 orthologues and 9 paralogues. Ubiquitous expression in testis (RPKM 13.1), lymph node (RPKM 11.7) and 25 other tissues.

功能概要

启用多种功能，包括胍基核苷酸交换因子活性；核小体 DNA 结合活性；和蛋白质异二聚化活性。参与多个过程，包括有丝分裂细胞周期的 G1/S 转换；有丝分裂核分裂的调节；和主轴组织。位于染色质；细胞质；和核。部分含蛋白质复合物。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including guanyl-nucleotide exchange factor activity; nucleosomal DNA binding activity; and protein heterodimerization activity. Involved in several processes, including G1/S transition of mitotic cell cycle; regulation of mitotic nuclear division; and spindle organization. Located in chromatin; cytoplasm; and nucleus. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]

RCC1 基因产物(6)

mRNA	Protein	Name
NM_001048194.4	NP_001041659.1	regulator of chromosome condensation isoform a
NM_001048195.4	NP_001041660.1	regulator of chromosome condensation isoform b
NM_001048199.3	NP_001041664.1	regulator of chromosome condensation isoform c
NM_001269.6	NP_001260.1	regulator of chromosome condensation isoform c
NM_001381865.2	NP_001368794.1	regulator of chromosome condensation isoform c
NM_001381866.2	NP_001368795.1	regulator of chromosome condensation isoform c

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables chromatin binding	IDA IDA: 通过直接分析推断	2677018	GOA
enables guanyl-nucleotide exchange factor activity	IDA IDA: 通过直接分析推断	1944575	GOA
enables guanyl-nucleotide exchange factor activity	IMP IMP: 通过突变表型推断	11336674	GOA
enables histone binding	IDA IDA: 通过直接分析推断	11375490	GOA
enables nucleosomal DNA binding	IDA IDA: 通过直接分析推断	17435751	GOA
enables nucleosome binding	IMP IMP: 通过突变表型推断	20347844	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	1961752	GOA
enables protein heterodimerization activity	IPI IPI: 通过物理相互作用推断	11336674	GOA
enables small GTPase binding	IDA IDA: 通过直接分析推断	11336674	GOA
enables sulfate binding	IDA IDA: 通过直接分析推断	11336674	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in G1/S transition of mitotic cell cycle	IMP IMP: 通过突变表型推断	3678831	GOA
involved in chromosome segregation	IMP IMP: 通过突变表型推断	17435751	GOA
involved in mitotic spindle organization	IDA IDA: 通过直接分析推断	15014043	GOA
involved in regulation of mitotic nuclear division	IDA IDA: 通过直接分析推断	15014043	GOA
involved in spindle assembly	IMP IMP: 通过突变表型推断	17435751	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in chromatin	IDA IDA: 通过直接分析推断	12121620	GOA
located in condensed nuclear chromosome	IDA IDA: 通过直接分析推断	15014043	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	17435751	GOA
located in nucleus	IDA IDA: 通过直接分析推断	17435751	GOA
part of protein-containing complex	IDA IDA: 通过直接分析推断	11336674	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RCC1 蛋白结构

RCC1

0
100
200
300
421 a.a.

蛋白主名

其他名称

regulator of chromosome condensation

cell cycle regulatory protein

RCC1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	RCC1	P18754	RAN	Homo sapiens	P62826	SLC	31467278
种属内	RCC1	P18754	RAN	Homo sapiens	P62826	Lumier	29997244
种属内	RCC1	P18754	RAN	Homo sapiens	P62826	MAPPIT	31467278
种属内	RCC1	P18754	RAN	Homo sapiens	P62826	X-Ray Diffraction	11336674
种属内	RCC1	P18754	XPO1	Homo sapiens	O14980	Pull Down	11932251
种属内	RCC1	P18754	RANBP3	Homo sapiens	Q9H6Z4	Pull Down	11932251
种属内	RCC1	P18754	RANBP3	Homo sapiens	Q9H6Z4	Y2H	11932251

种属间: 跨种属相互作用 种属内: 同种属相互作用

RCC1 抗体

目录号	产品名	应用	反应物种
HY-P82897	RCC1 Antibody (YA2642)	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat

关联疾病

疾病名称

别名

Microcystic Meningioma

Raynaud Disease

Raynaud'S Disease	Raynaud Phenomenon
Raynaud'S Syndrome	Raynaud'S
Cold Fingers, Hereditary	Raynaud'S Phenomenon
Raynaud'S Disease/Phenomenon	Raynauds Syndrome
Raynauds Phenomenon	Secondary Raynaud'S Phenomenon
Raynaud Syndrome

Retinitis Pigmentosa 3

RP3	Retinitis Pigmentosa 15
Rp15	Choroidoretinal Degeneration With Retinal Reflex In Heterozygous Women
Cone-Rod Degeneration, X-Linked	Retinitis Pigmentosa Type 15
X-Linked Cone-Rod Degeneration	X-Linked Retinitis Pigmentosa 3
Xlrp3	Xlrp-3
Retinitis Pigmentosa-3	Retinitis Pigmentosa, Type 3

Joubert Syndrome 7

JBTS7	Cerebello-Oculo-Renal Syndrome 3
Cors3	Joubert Syndrome, Type 7

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Cone-Rod Dystrophy 2

Cone-Rod Dystrophy	CORD2
Cone-Rod Retinal Dystrophy	Rcrd2
Cone-Rod Retinal Dystrophy 2	Crd2
Cord	Crd
Retinal Cone-Rod Dystrophy	Cone-Rod Retinal Dystrophy-2
Retinal Cone-Rod Dystrophy 2	Tapetoretinal Degeneration
Cone-Rod Degeneration	Cone Rod Dystrophy
Dystrophy, Cone-Rod	Dystrophy, Cone-Rod, Type 2
Retinitis Pigmentosa	Retinitis Pigmentosa 2
Progressive Cone-Rod Dystrophy

Fundus Dystrophy

Retinal Dystrophy	Retinal Dystrophies
Dystrophy, Retinal

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-119425	Razoxane	Inhibitor	99.16%	否
HY-RS11783	RCC1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	RCC1	RGD	RGD:1592835
Bos taurus	RCC1	VGNC	VGNC:33825
Macaca mulatta	RCC1	VGNC	VGNC:107115
Felis catus	RCC1	VGNC	VGNC:64544
Mus musculus	RCC1	MGD	MGI:1913989
Canis familiaris	RCC1	VGNC	VGNC:45440
Others	RCC1	NCBI

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