RAN - RAN, member RAS oncogene family Gene

中文名称：RAN，成员 RAS 致癌基因家族

种属: Homo sapiens

同用名: TC4; Gsp1; ARA24

关于 RAN

功能概要

RAN (Ras 相关核蛋白) 是一种小的 GTP 结合蛋白，属于 Ras 超家族，对于 RNA 和蛋白质通过核孔复合物的转运至关重要。 RAN 蛋白还参与控制 DNA 合成和细胞周期进程。 RAN 的核定位需要存在染色体浓缩调节因子 1 (RCC1) 。 RAN 中的突变会破坏 DNA 合成。由于其许多功能，RAN 很可能与其他几种蛋白质相互作用。 RAN 调节微管网络的形成和组织，而与其在大分子的细胞核-细胞质交换中的作用无关。 RAN 可能是调节有丝分裂过程中微管聚合的关键信号分子。 RCC1 在染色质周围产生局部高浓度的 RAN-GTP，进而诱导微管的局部成核。 RAN 是一种雄激素受体 (AR) 共激活剂，它与雄激素受体内不同长度的聚谷氨酰胺有差异地结合。 AR 中的聚谷氨酰胺重复扩增与肯尼迪氏病 (X 连锁脊髓和延髓肌萎缩症) 有关。 AR 的 RAN 共激活随着 AR 内聚谷氨酰胺的扩张而减弱，这种弱的共激活可能导致肯尼迪病发展过程中部分雄激素不敏感。[RefSeq 提供，2008 年 7 月]

RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the Ras superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its many functions, it is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of microtubules. RAN is an Androgen Receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the Androgen Receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). RAN coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease. [provided by RefSeq, Jul 2008]