2. Gene
  3. CHMP7 - charged multivesicular body protein 7 Gene

CHMP7 - charged multivesicular body protein 7 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：带电多泡体蛋白 7

种属: Homo sapiens

基因 ID: 91782 | 基因类型: protein coding

关于 CHMP7

Cytogenetic location: 8p21.3 Genomic coordinates (GRCh38): 8:23,243,637-23,261,999 (from NCBI)

This gene has 10 transcripts (splice variants), 203 orthologues and 4 paralogues. Ubiquitous expression in lymph node (RPKM 21.0), appendix (RPKM 14.0) and 25 other tissues.

功能概要

参与多个过程，包括晚期内体到液泡的运输；中体脱落；和有丝分裂核分裂。位于胞质溶胶中；核包膜；和核质。 ESCRT III 复合体的一部分。与染色质共定位。 [由基因组资源联盟提供，2022 年 4 月]

Involved in several processes, including late endosome to vacuole transport; midbody abscission; and mitotic nuclear division. Located in cytosol; nuclear envelope; and nucleoplasm. Part of ESCRT III complex. Colocalizes with chromatin. [provided by Alliance of Genome Resources, Apr 2022]

CHMP7 基因产物(3)

mRNA Protein Name
NM_001317899.2 NP_001304828.1 charged multivesicular body protein 7 isoform 2
NM_001363183.2 NP_001350112.1 charged multivesicular body protein 7 isoform 3
NM_152272.5 NP_689485.1 charged multivesicular body protein 7 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16856878 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in autophagosome maturation IMP
IMP: 通过突变表型推断
17984323 GOA
involved in autophagy IMP
IMP: 通过突变表型推断
17984323 GOA
involved in exit from mitosis IMP
IMP: 通过突变表型推断
26040712 GOA
involved in late endosome to lysosome transport IMP
IMP: 通过突变表型推断
17984323 GOA
involved in late endosome to vacuole transport IMP
IMP: 通过突变表型推断
16856878 GOA
involved in midbody abscission IMP
IMP: 通过突变表型推断
20616062 GOA
involved in mitotic metaphase chromosome alignment IMP
IMP: 通过突变表型推断
20616062 GOA
involved in multivesicular body sorting pathway IDA
IDA: 通过直接分析推断
16554368 GOA
involved in nuclear membrane reassembly IMP
IMP: 通过突变表型推断
26040712 GOA
involved in nucleus organization IMP
IMP: 通过突变表型推断
20616062 GOA
involved in plasma membrane repair IDA
IDA: 通过直接分析推断
24482116 GOA
involved in protein localization to chromatin IMP
IMP: 通过突变表型推断
28242692 GOA
involved in regulation of mitotic spindle assembly IMP
IMP: 通过突变表型推断
20616062 GOA
involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IDA
IDA: 通过直接分析推断
17984323 GOA
involved in viral budding from plasma membrane IDA
IDA: 通过直接分析推断
24878737 GOA
involved in viral budding via host ESCRT complex IDA
IDA: 通过直接分析推断
24878737 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of ESCRT III complex IDA
IDA: 通过直接分析推断
16856878 GOA
located in amphisome membrane IDA
IDA: 通过直接分析推断
17984323 GOA
located in autophagosome membrane IDA
IDA: 通过直接分析推断
17984323 GOA
located in chromatin IDA
IDA: 通过直接分析推断
28242692 GOA
located in kinetochore IDA
IDA: 通过直接分析推断
26040712 GOA
located in kinetochore microtubule IDA
IDA: 通过直接分析推断
26040712 GOA
located in lysosomal membrane IDA
IDA: 通过直接分析推断
17984323 GOA
located in midbody IDA
IDA: 通过直接分析推断
26040712 GOA
located in multivesicular body membrane IDA
IDA: 通过直接分析推断
16554368 GOA
located in nuclear envelope IDA
IDA: 通过直接分析推断
26040712 GOA
part of nuclear pore IDA
IDA: 通过直接分析推断
26040713 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
24878737 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CHMP7 蛋白结构

Snf7

Snf7: Snf7 (243 - 404)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 453 a.a.
蛋白主名 其他名称

charged multivesicular body protein 7

CHMP family, member 7

CHMP7 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra CHMP7 Q8WUX9 FGFR3 Homo sapiens P22607
Validated Y2H
32814053
Intra CHMP7 Q8WUX9 FGFR3 Homo sapiens P22607
Y2H Pooling
32814053
Intra CHMP7 Q8WUX9 FGFR3 Homo sapiens P22607
Y2H Array
32814053
Intra CHMP7 Q8WUX9 HRAS Homo sapiens P01112
Y2H Pooling
32814053
Intra CHMP7 Q8WUX9 HRAS Homo sapiens P01112
Validated Y2H
32814053
Intra CHMP7 Q8WUX9 HRAS Homo sapiens P01112
Y2H Array
32814053
Intra CHMP7 Q8WUX9 GSN Homo sapiens P06396
Y2H Array
32814053
Intra CHMP7 Q8WUX9 GSN Homo sapiens P06396
Validated Y2H
32814053
Intra CHMP7 Q8WUX9 GSN Homo sapiens P06396
Y2H Pooling
32814053
Intra CHMP7 Q8WUX9 PMP22 Homo sapiens A0A6Q8PF08
Validated Y2H
32814053
Intra CHMP7 Q8WUX9 PMP22 Homo sapiens A0A6Q8PF08
Y2H Array
32814053
Intra CHMP7 Q8WUX9 PMP22 Homo sapiens A0A6Q8PF08
Y2H Pooling
32814053
Intra CHMP7 Q8WUX9 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32814053
Intra CHMP7 Q8WUX9 SPRED1 Homo sapiens Q7Z699
Y2H Pooling
32814053
Intra CHMP7 Q8WUX9 SPRED1 Homo sapiens Q7Z699
Y2H Array
32814053
Intra CHMP7 Q8WUX9 CHMP4B Homo sapiens Q9H444
Y2H
16856878
Intra CHMP7 Q8WUX9 CHMP4B Homo sapiens Q9H444
Pull Down
16856878
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS02648 CHMP7 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus CHMP7 VGNC VGNC:60866
Rattus norvegicus CHMP7 RGD RGD:1308779
Bos taurus CHMP7 VGNC VGNC:27306
Mus musculus CHMP7 MGD MGI:1913922
Canis familiaris CHMP7 VGNC VGNC:54933
Macaca mulatta CHMP7 VGNC VGNC:71122
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