2. Gene
  3. AK8 - adenylate kinase 8 Gene

AK8 - adenylate kinase 8 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：腺苷酸激酶 8

种属: Homo sapiens

同用名: AK 8; DDX31; C9orf98

基因 ID: 158067 | 基因类型: protein coding

关于 AK8

Cytogenetic location: 9q34.13 Genomic coordinates (GRCh38): 9:132,725,578-132,879,046 (from NCBI)

This gene has 5 transcripts (splice variants), 107 orthologues and 9 paralogues. Biased expression in testis (RPKM 3.3), thyroid (RPKM 0.7) and 8 other tissues.

功能概要

启用 AMP 结合活性和含核碱基的复合激酶活性。参与核苷二磷酸磷酸化和核苷三磷酸生物合成过程。位于 9+2 运动纤毛中。 [由基因组资源联盟提供，2022 年 4 月]

Enables AMP binding activity and nucleobase-containing compound kinase activity. Involved in nucleoside diphosphate phosphorylation and nucleoside triphosphate biosynthetic process. Located in 9+2 motile cilium. [provided by Alliance of Genome Resources, Apr 2022]

AK8 基因产物(7)

mRNA Protein Name
NM_001317958.2 NP_001304887.1 adenylate kinase 8 isoform 2
NM_001317959.2 NP_001304888.1 adenylate kinase 8 isoform 3
NM_001371771.1 NP_001358700.1 adenylate kinase 8 isoform 4
NM_001371772.1 NP_001358701.1 adenylate kinase 8 isoform 5
NM_001371773.1 NP_001358702.1 adenylate kinase 8 isoform 2
NM_001371774.1 NP_001358703.1 adenylate kinase 8 isoform 2
NM_152572.3 NP_689785.1 adenylate kinase 8 isoform 1
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables (d)CMP kinase activity IDA
IDA: 通过直接分析推断
21080915 GOA
enables AMP binding IDA
IDA: 通过直接分析推断
33139725 GOA
enables adenylate kinase activity IDA
IDA: 通过直接分析推断
21080915 GOA
enables nucleoside diphosphate kinase activity IDA
IDA: 通过直接分析推断
23416111 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in 9+2 motile cilium IDA
IDA: 通过直接分析推断
33139725 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

AK8 蛋白结构

ADK

ADK: Adenylate kinase (62 - 234)

ADK

ADK: Adenylate kinase (273 - 447)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 479 a.a.
蛋白主名 其他名称

adenylate kinase 8

ATP-AMP transphosphorylase 8

关联疾病

疾病名称 别名
Reticular Dysgenesis

Severe Combined Immunodeficiency With Leukopenia

De Vaal Disease

Congenital Aleukia

Aleukocytosis

Hematopoietic Hypoplasia, Generalized

Reticular Dysgenesia

Devaal Disease

Rd

Ak2 Deficiency

Congenital Aleukocytosis

Generalized Hematopoietic Hypoplasia

Scid With Leukopenia

RDYS
Ovary Serous Adenocarcinoma

Malignant Ovarian Serous Tumor

Serous Carcinoma Of Ovary
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00510 AK8 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus AK8 VGNC VGNC:59709
Canis familiaris AK8 VGNC VGNC:37749
Mus musculus AK8 MGD MGI:1916120
Macaca mulatta AK8 VGNC VGNC:69710
Bos taurus AK8 VGNC VGNC:25777
Rattus norvegicus AK8 RGD RGD:1303144
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