2. Gene
  3. ALKBH3 - alkB homolog 3, alpha-ketoglutarate dependent dioxygenase Gene

ALKBH3 - alkB homolog 3, alpha-ketoglutarate dependent dioxygenase Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：alkB 同系物 3，α-酮戊二酸依赖性双加氧酶

种属: Homo sapiens

同用名: ABH3; PCA1; DEPC1; hABH3; DEPC-1

基因 ID: 221120 | 基因类型: protein coding

关于 ALKBH3

Cytogenetic location: 11p11.2 Genomic coordinates (GRCh38): 11:43,880,831-43,920,274 (from NCBI)

This gene has 12 transcripts (splice variants) and 196 orthologues. Ubiquitous expression in testis (RPKM 6.9), prostate (RPKM 6.8) and 25 other tissues.

功能概要

大肠杆菌 AlkB 蛋白通过修复单链 DNA 中产生的特定 DNA 损伤来防止甲基化剂的细胞毒性。 ALKBH2 (MIM 610602) 和 ALKBH3 是大肠杆菌 AlkB 同系物，可催化去除 1-甲基腺嘌呤和 3-甲基胞嘧啶 (Duncan 等人，2002 [PubMed 12486230]) 。[OMIM 提供，2008 年 3 月]

The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA. ALKBH2 (MIM 610602) and ALKBH3 are E. coli AlkB homologs that catalyze the removal of 1-methyladenine and 3-methylcytosine (Duncan et al., 2002 [PubMed 12486230]).[supplied by OMIM, Mar 2008]

ALKBH3 基因产物(1)

mRNA Protein Name
NM_139178.4 NP_631917.1 alpha-ketoglutarate-dependent dioxygenase alkB homolog 3
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables broad specificity oxidative DNA demethylase activity IDA
IDA: 通过直接分析推断
12486230 GOA
enables broad specificity oxidative DNA demethylase activity IMP
IMP: 通过突变表型推断
22055184 GOA
enables ferrous iron binding IDA
IDA: 通过直接分析推断
16858410 GOA
enables mRNA N1-methyladenosine dioxygenase activity IDA
IDA: 通过直接分析推断
26863196 GOA
enables oxidative RNA demethylase activity IDA
IDA: 通过直接分析推断
16174769 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
22055184 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA alkylation repair IDA
IDA: 通过直接分析推断
20714506 GOA
involved in cell population proliferation IMP
IMP: 通过突变表型推断
22055184 GOA
involved in negative regulation of cytoplasmic translation IDA
IDA: 通过直接分析推断
26863196 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ALKBH3 蛋白结构

2OG-FeII_Oxy_2

2OG-FeII_Oxy_2: 2OG-Fe(II) oxygenase superfamily (90 - 275)

  • 0
  • 100
  • 200
  • 286 a.a.
蛋白主名 其他名称

alpha-ketoglutarate-dependent dioxygenase alkB homolog 3

alkB homolog 3, alpha-ketoglutaratedependent dioxygenase

关联疾病

疾病名称 别名
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-100199 HUHS015 Inhibitor 99.85% 否
HY-RS00605 ALKBH3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris ALKBH3 VGNC VGNC:37804
Macaca mulatta ALKBH3 VGNC VGNC:69736
Felis catus ALKBH3 VGNC VGNC:59751
Mus musculus ALKBH3 MGD MGI:1916363
Bos taurus ALKBH3 VGNC VGNC:25834
Rattus norvegicus ALKBH3 RGD RGD:1359731
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