2. Gene
  3. MCM7 - minichromosome maintenance complex component 7 Gene

MCM7 - minichromosome maintenance complex component 7 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：微染色体维护复杂组件 7

种属: Homo sapiens

同用名: MCM2; CDC47; P85MCM; P1CDC47; PNAS146; PPP1R104; P1.1-MCM3

基因 ID: 4176 | 基因类型: protein coding

关于 MCM7

Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:100,092,728-100,101,397 (from NCBI)

This gene has 13 transcripts (splice variants), 192 orthologues and 8 paralogues. Ubiquitous expression in bone marrow (RPKM 53.3), lymph node (RPKM 33.2) and 24 other tissues.

功能概要

由该基因编码的蛋白质是高度保守的微型染色体维护蛋白 (MCM) 之一，对于启动真核基因组复制至关重要。由 MCM 蛋白形成的六聚体蛋白复合物是复制前复合物 (pre_RC) 的关键组成部分，可能参与复制叉的形成和其他 DNA 复制相关蛋白的募集。由该蛋白和 MCM2、4、6 蛋白组成的 MCM 复合物具有 DNA 解旋酶活性，可作为 DNA 解旋酶。发现细胞周期蛋白 D1 依赖性激酶 CDK4 与该蛋白相关，并可能调节该蛋白与肿瘤抑制蛋白 RB1/RB 的结合。已经报道了编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding Enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

MCM7 基因产物(3)

mRNA Protein Name
NM_001278595.2 NP_001265524.1 DNA replication licensing factor MCM7 isoform 2
NM_005916.5 NP_005907.3 DNA replication licensing factor MCM7 isoform 1
NM_182776.3 NP_877577.1 DNA replication licensing factor MCM7 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
contributes to DNA helicase activity IDA
IDA: 通过直接分析推断
9305914 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
9705868 GOA
contributes to single-stranded DNA binding IDA
IDA: 通过直接分析推断
25661590 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA damage response IMP
IMP: 通过突变表型推断
15538388 GOA
involved in DNA unwinding involved in DNA replication IDA
IDA: 通过直接分析推断
22474384 GOA
involved in regulation of phosphorylation IMP
IMP: 通过突变表型推断
15538388 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of CMG complex IPI
IPI: 通过物理相互作用推断
22474384 GOA
part of MCM complex IDA
IDA: 通过直接分析推断
17296731 GOA
part of MCM complex IMP
IMP: 通过突变表型推断
15538388 GOA
part of MCM complex IPI
IPI: 通过物理相互作用推断
22540012 GOA
NOT located in nucleolus IDA
IDA: 通过直接分析推断
21383955 GOA
located in nucleus IDA
IDA: 通过直接分析推断
21383955 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MCM7 蛋白结构

MCM_N

MCM_N: MCM N-terminal domain (11 - 165)

MCM

MCM: MCM2/3/5 family (322 - 640)

  • 0
  • 200
  • 400
  • 600
  • 719 a.a.
蛋白主名 其他名称

DNA replication licensing factor MCM7

CDC47 homolog

MCM7 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra MCM7 P33993 CCDC102B Homo sapiens Q68D86
Y2H Array
25416956
Intra MCM7 P33993 CCDC102B Homo sapiens Q68D86
Y2H Prey Pooling
25416956
Intra MCM7 P33993 UBQLN1 Homo sapiens Q9UMX0-2
Y2H Prey Pooling
25416956
Intra MCM7 P33993 UBQLN1 Homo sapiens Q9UMX0-2
Validated Y2H
25416956
Intra MCM7 P33993 UBQLN1 Homo sapiens Q9UMX0-2
Y2H Array
25416956
Intra MCM7 P33993 MBIP Homo sapiens Q9NS73-5
Y2H Array
25416956
Cross MCM7 P33993 E6 Human papillomavirus P03126
Pull Down
9705868
Cross MCM7 P33993 E6 Human papillomavirus P03126
Pull Down
14675634
Cross MCM7 P33993 E6 Human papillomavirus P06463
Pull Down
9705868
Intra MCM7 P33993 INTS6 Homo sapiens Q9UL03
Anti Bait CoIP
17310990
Intra MCM7 P33993 INTS6 Homo sapiens Q9UL03
Pull Down
17310990
Intra MCM7 P33993 KIFC3 Homo sapiens Q9BVG8
Validated Y2H
25416956
Intra MCM7 P33993 TRIM54 Homo sapiens Q9BYV2
Validated Y2H
25416956
Intra MCM7 P33993 MIPOL1 Homo sapiens Q8TD10
Validated Y2H
25416956
Intra MCM7 P33993 FKBP5 Homo sapiens Q13451
Lumier
25036637
Intra MCM7 P33993 SSRP1 Homo sapiens Q08945
Anti Bait CoIP
16902406
Intra MCM7 P33993 MCM5 Homo sapiens P33992
Anti Tag CoIP
23764002
Intra MCM7 P33993 MCM5 Homo sapiens P33992
Protein Array
15232106
Intra MCM7 P33993 MCM5 Homo sapiens P33992
Anti Tag CoIP
33961781
Intra MCM7 P33993 MCM2 Homo sapiens P49736
Anti Bait CoIP
23764002
Intra MCM7 P33993 MCM2 Homo sapiens P49736
TAP
17296731
Intra MCM7 P33993 MCM2 Homo sapiens P49736
Anti Tag CoIP
23764002
Intra MCM7 P33993 MCM6 Homo sapiens Q14566
Anti Bait CoIP
23764002
Intra MCM7 P33993 MCM6 Homo sapiens Q14566
TAP
17296731
Intra MCM7 P33993 MCM6 Homo sapiens Q14566
Anti Bait CoIP
17296731
Intra MCM7 P33993 MCM4 Homo sapiens P33991
Anti Bait CoIP
23764002
Intra MCM7 P33993 MCM4 Homo sapiens P33991
Anti Bait CoIP
24299456
Intra MCM7 P33993 MCM4 Homo sapiens P33991
TAP
17296731
Intra MCM7 P33993 MCM4 Homo sapiens P33991
Anti Bait CoIP
17296731
Intra MCM7 P33993 UBB Homo sapiens P0CG47
Anti Bait CoIP
17310990
Intra MCM7 P33993 MYC Homo sapiens P01106
Y2H
17314511
Intra MCM7 P33993 MYC Homo sapiens P01106
Anti Tag CoIP
17314511
Intra MCM7 P33993 PLK1 Homo sapiens P53350
Pull Down
15654075
Intra MCM7 P33993 PLK1 Homo sapiens P53350
CoIP
15654075
Intra MCM7 P33993 CDKN1C Homo sapiens P49918
Y2H Array
16289477
Intra MCM7 P33993 CDKN1C Homo sapiens P49918
Pull Down
16289477
Intra MCM7 P33993 CDKN1B Homo sapiens P46527
Y2H Fragment Pooling
16289477
Intra MCM7 P33993 GOLGA2 Homo sapiens Q08379
Y2H Array
25416956
Intra MCM7 P33993 GOLGA2 Homo sapiens Q08379
Validated Y2H
25416956
Intra MCM7 P33993 LYN Homo sapiens P07948-1
Anti Tag CoIP
23764002
Intra MCM7 P33993 LYN Homo sapiens P07948-1
Protein Kinase Assay
23764002
Cross MCM7 P33993 E6 Human papillomavirus P06462
Pull Down
9705868
Intra MCM7 P33993 TRIM27 Homo sapiens P14373
Y2H Prey Pooling
25416956
Intra MCM7 P33993 TRIM27 Homo sapiens P14373
Y2H Array
25416956
Intra MCM7 P33993 MCMBP Homo sapiens Q9BTE3
Anti Bait CoIP
17296731
Intra MCM7 P33993 MCMBP Homo sapiens Q9BTE3
Y2H Array
25416956
Intra MCM7 P33993 MCMBP Homo sapiens Q9BTE3
Y2H Prey Pooling
25416956
Intra MCM7 P33993 MCMBP Homo sapiens Q9BTE3
Anti Bait CoIP
22540012
Intra MCM7 P33993 MCMBP Homo sapiens Q9BTE3
TAP
17296731
Intra MCM7 P33993 MCMBP Homo sapiens Q9BTE3
Anti Bait CoIP
24299456
Intra MCM7 P33993 LYN Homo sapiens P07948
Anti Bait CoIP
23764002
Intra MCM7 P33993 SMC1A Homo sapiens Q14683
Anti Tag CoIP
16438930
Intra MCM7 P33993 SMC1A Homo sapiens Q14683
Anti Bait CoIP
16438930
Intra MCM7 P33993 AK8 Homo sapiens Q96MA6
Y2H Array
25416956
Intra MCM7 P33993 AK8 Homo sapiens Q96MA6
Y2H Array
31515488
Intra MCM7 P33993 NAB2 Homo sapiens Q15742
Validated Y2H
25416956
Intra MCM7 P33993 SP2 Homo sapiens Q02086
Y2H Prey Pooling
25416956
Intra MCM7 P33993 MCMBP Homo sapiens Q9BTE3-2
Validated Y2H
26871637
Intra MCM7 P33993 MCMBP Homo sapiens Q9BTE3-2
Validated Y2H
32296183
Intra MCM7 P33993 MCMBP Homo sapiens Q9BTE3-2
Y2H Array
26871637
Intra MCM7 P33993 MCMBP Homo sapiens Q9BTE3-2
Y2H Array
32296183
Intra MCM7 P33993 MCMBP Homo sapiens Q9BTE3-2
Y2H Prey Pooling
26871637
Intra MCM7 P33993 MCMBP Homo sapiens Q9BTE3-2
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Meier-Gorlin Syndrome 1

Meier-Gorlin Syndrome

Ear, Patella, Short Stature Syndrome

Microtia, Absent Patellae, Micrognathia Syndrome

MGORS1

Eps

Ear-Patella-Short Stature Syndrome

Ear Patella Short Stature Syndrome

Microtia Absent Patellae Micrognathia Syndrome

Meier-Gorlin Syndrome, Type 1
Follicular Adenoma

Follicular Adenoma Of The Thyroid Gland

Thyroid Follicular Adenoma

Adenoma Follicular

Follicular Thyroid Adenoma

Thyroid Gland Follicular Adenoma
Deafness, Autosomal Dominant 70

DFNA70

Autosomal Dominant Nonsyndromic Deafness 70

Autosomal Dominant Deafness 70

Deafness, Autosomal Dominant, 70
Retinoblastoma

RB

Trilateral Retinoblastoma

RB1

Retinoblastoma, Trilateral

Neuroblastoma Of Retina

Rb - Retinoblastoma

Eye Cancer, Retinoblastoma

Retinal Cancer

Retinal Tumor

Glioma, Retinal

Non-Hereditary Retinoblastoma

Childhood Cancer Retinoblastoma

Malignant Neoplasm Of Retina

Retinal Neoplasms
Cervix Endometriosis

Endometriosis Of Cervix

Cervical Endometriosis
Cardiomyopathy, Familial Hypertrophic, 6

Hypertrophic Cardiomyopathy 6

CMH6

Familial Hypertrophic Cardiomyopathy With Wolff-Parkinson-White Syndrome

Cardiomyopathy, Familial Hypertrophic 6

Cardiomyopathy, Hypertrophic 6

Cardiomyopathy, Hypertrophic, Familial, Type 6
Meier-Gorlin Syndrome 5

MGORS5

Meier-Gorlin Syndrome, Type 5
Immunodeficiency 7

Tcr-Alpha-Beta-Positive T-Cell Deficiency

IMD7

T-Cell Receptor-Alpha/Beta Deficiency

Immunodeficiency 7, Tcr-Alpha/Beta Deficient

Tcr-Alpha/Beta Deficiency

Tcr-Alpha-Beta+ T-Cell Deficiency

T-Cell Receptor Alpha/Beta Deficiency
Anus Cancer

Anal Cancer

Anal Carcinoma

Malignant Anal Tumor

Cancer Of The Anus

Malignant Neoplasm Of Anus

Anus Neoplasms
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer
Medulloblastoma

MDB

Cpnet

Localized Primitive Neuroectodermal Tumor

Classic Medulloblastoma

Medulloblastoma Predisposition Syndrome

Medulloblastoma, Somatic

Brain Medulloblastoma

Cns Pnet

Infratentorial Primitive Neuroectodermal Tumor

Neuroectodermal Tumors, Primitive

Medulloblastomas

Desmoplastic Medulloblastoma

Medulloblastoma, With Extensive Nodularity

Medulloblastoma Of Unspecified Site

Medullomyoblastoma Of Unspecified Site
Microcephaly

Microencephaly

Microcephalus

Microcephalic

Nanocephaly

Congenital Microcephaly

Brain Hypoplasia

Brain Nondevelopment

Cephalic Hypoplasia

Undeveloped Cerebrum

Undeveloped Brain

Micrencephalon

Micrencephaly
Fanconi Anemia, Complementation Group A

Fanconi Anemia

Fanconi Pancytopenia

Fanconi Anemia Complementation Group A

FANCA

Fa

Fanconi Panmyelopathy

Fanconi'S Anemia

Fanconi Anaemia

Fanconi'S Anaemia

Fanconi Hypoplastic Anemia

Estren-Dameshek Variant Of Fanconi Anemia

Estren-Dameshek Variant Of Fanconi Pancytopenia

Fanconi Anemia Estren-Dameshek Variant

Fanconis Anemia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS08240 MCM7 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta MCM7 VGNC VGNC:74686
Felis catus MCM7 VGNC VGNC:68218
Mus musculus MCM7 MGD MGI:1298398
Canis familiaris MCM7 VGNC VGNC:43087
Rattus norvegicus MCM7 RGD RGD:1303018
Bos taurus MCM7 VGNC VGNC:31313
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