2. Gene
  3. KIFC3 - kinesin family member C3 Gene

KIFC3 - kinesin family member C3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：驱动蛋白家族成员 C3

种属: Homo sapiens

基因 ID: 3801 | 基因类型: protein coding

关于 KIFC3

Cytogenetic location: 16q21 Genomic coordinates (GRCh38): 16:57,758,217-57,862,858 (from NCBI)

This gene has 35 transcripts (splice variants), 202 orthologues and 41 paralogues. Broad expression in kidney (RPKM 11.2), testis (RPKM 9.9) and 24 other tissues.

功能概要

该基因编码微管马达驱动蛋白 14 家族的成员。该家族的成员在双极有丝分裂纺锤体的形成、维持和重塑中发挥作用。该基因编码的蛋白质在间期细胞中具有细胞质功能。它也可能参与胞质分裂的最后阶段。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供，2016 年 1 月]

This gene encodes a member of the Kinesin-14 family of microtubule motors. Members of this family play a role in the formation, maintenance and remodeling of the bipolar mitotic spindle. The protein encoded by this gene has cytoplasmic functions in the interphase cells. It may also be involved in the final stages of cytokinesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]

KIFC3 基因产物(9)

mRNA Protein Name
NM_001130099.1 NP_001123571.1 kinesin-like protein KIFC3 isoform 3
NM_001130100.2 NP_001123572.1 kinesin-like protein KIFC3 isoform 2
NM_001318710.2 NP_001305639.1 kinesin-like protein KIFC3 isoform 4
NM_001318711.2 NP_001305640.1 kinesin-like protein KIFC3 isoform 5
NM_001318712.2 NP_001305641.1 kinesin-like protein KIFC3 isoform 6
NM_001318713.2 NP_001305642.1 kinesin-like protein KIFC3 isoform 7
NM_001318714.2 NP_001305643.1 kinesin-like protein KIFC3 isoform 3
NM_001318715.2 NP_001305644.1 kinesin-like protein KIFC3 isoform 3
NM_005550.4 NP_005541.3 kinesin-like protein KIFC3 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
20360068 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in epithelial cell-cell adhesion IMP
IMP: 通过突变表型推断
19041755 GOA
involved in zonula adherens maintenance IMP
IMP: 通过突变表型推断
19041755 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in centrosome IDA
IDA: 通过直接分析推断
19041755 GOA
located in zonula adherens IDA
IDA: 通过直接分析推断
19041755 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

KIFC3 蛋白结构

Kinesin

Kinesin: Kinesin motor domain (451 - 768)

  • 0
  • 200
  • 400
  • 600
  • 833 a.a.
蛋白主名 其他名称

kinesin-like protein KIFC3

KIFC3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra KIFC3 Q9BVG8 CCDC102B Homo sapiens Q68D86
Validated Y2H
25416956
Intra KIFC3 Q9BVG8 CCDC102B Homo sapiens Q68D86
Y2H Array
25416956
Intra KIFC3 Q9BVG8 CCDC102B Homo sapiens Q68D86
Y2H Prey Pooling
25416956
Intra KIFC3 Q9BVG8 FLJ13057 Homo sapiens Q53SE7
Y2H Prey Pooling
25416956
Intra KIFC3 Q9BVG8 MID2 Homo sapiens Q9UJV3-2
Y2H Prey Pooling
25416956
Intra KIFC3 Q9BVG8 ZNF572 Homo sapiens Q7Z3I7
Validated Y2H
25416956
Intra KIFC3 Q9BVG8 ZNF572 Homo sapiens Q7Z3I7
Y2H Array
25416956
Intra KIFC3 Q9BVG8 ZNF572 Homo sapiens Q7Z3I7
Y2H Prey Pooling
25416956
Intra KIFC3 Q9BVG8 ITGB3BP Homo sapiens Q13352-5
Validated Y2H
25416956
Intra KIFC3 Q9BVG8 ITGB3BP Homo sapiens Q13352-5
Y2H Array
25416956
Intra KIFC3 Q9BVG8 NEFL Homo sapiens I6L9F6
Y2H Array
25416956
Intra KIFC3 Q9BVG8 ZGPAT Homo sapiens Q8N5A5-2
Validated Y2H
25416956
Intra KIFC3 Q9BVG8 ZGPAT Homo sapiens Q8N5A5-2
Y2H Array
25416956
Intra KIFC3 Q9BVG8 TPM3 Homo sapiens Q5VU62
Validated Y2H
25416956
Intra KIFC3 Q9BVG8 TPM3 Homo sapiens Q5VU62
Y2H Array
25416956
Intra KIFC3 Q9BVG8 CCDC28A Homo sapiens Q7Z6N9
Y2H Prey Pooling
25416956
Intra KIFC3 Q9BVG8 ICA1L Homo sapiens Q8NDH6
Y2H Array
25416956
Intra KIFC3 Q9BVG8 CYTH4 Homo sapiens Q8WWE8
Y2H Prey Pooling
25416956
Intra KIFC3 Q9BVG8 CYTH4 Homo sapiens Q8WWE8
Y2H Array
25416956
Intra KIFC3 Q9BVG8 ZNF180 Homo sapiens Q9UJW8
Validated Y2H
25416956
Intra KIFC3 Q9BVG8 ZNF180 Homo sapiens Q9UJW8
Y2H Array
25416956
Intra KIFC3 Q9BVG8 MFAP1 Homo sapiens P55081
Y2H Prey Pooling
25416956
Intra KIFC3 Q9BVG8 MFAP1 Homo sapiens P55081
Y2H Array
25416956
Intra KIFC3 Q9BVG8 MFAP1 Homo sapiens P55081
Validated Y2H
25416956
Intra KIFC3 Q9BVG8 RAD51D Homo sapiens O75771
Y2H Array
31515488
Intra KIFC3 Q9BVG8 RAD51D Homo sapiens O75771
Y2H Array
25416956
Intra KIFC3 Q9BVG8 ATF2 Homo sapiens P15336
Y2H Array
25416956
Intra KIFC3 Q9BVG8 ATF2 Homo sapiens P15336
Validated Y2H
25416956
Intra KIFC3 Q9BVG8 CDR2 Homo sapiens Q01850
Validated Y2H
25416956
Intra KIFC3 Q9BVG8 CDR2 Homo sapiens Q01850
Y2H Array
25416956
Intra KIFC3 Q9BVG8 FCHSD2 Homo sapiens O94868
Y2H Prey Pooling
25416956
Intra KIFC3 Q9BVG8 FCHSD2 Homo sapiens O94868
Validated Y2H
25416956
Intra KIFC3 Q9BVG8 PRKAA2 Homo sapiens P54646
Y2H Array
25416956
Intra KIFC3 Q9BVG8 PRKAA2 Homo sapiens P54646
Y2H
21516116
Intra KIFC3 Q9BVG8 PRKAA2 Homo sapiens P54646
Y2H Prey Pooling
25416956
Intra KIFC3 Q9BVG8 TRIM54 Homo sapiens Q9BYV2
Validated Y2H
25416956
Intra KIFC3 Q9BVG8 FANCL Homo sapiens Q9NW38
Validated Y2H
25416956
Intra KIFC3 Q9BVG8 FANCL Homo sapiens Q9NW38
Y2H Prey Pooling
25416956
Intra KIFC3 Q9BVG8 HAUS1 Homo sapiens Q96CS2
Y2H Array
25416956
Intra KIFC3 Q9BVG8 HAUS1 Homo sapiens Q96CS2
Y2H Prey Pooling
25416956
Intra KIFC3 Q9BVG8 KRT6C Homo sapiens P48668
Validated Y2H
25416956
Intra KIFC3 Q9BVG8 KRT6C Homo sapiens P48668
Y2H Prey Pooling
25416956
Intra KIFC3 Q9BVG8 ESRRG Homo sapiens P62508
Y2H Prey Pooling
25416956
Intra KIFC3 Q9BVG8 ESRRG Homo sapiens P62508
Y2H Array
25416956
Intra KIFC3 Q9BVG8 ZGPAT Homo sapiens Q8N5A5
Y2H Prey Pooling
25416956
Intra KIFC3 Q9BVG8 TSG101 Homo sapiens Q99816
Y2H Prey Pooling
25416956
Intra KIFC3 Q9BVG8 TSG101 Homo sapiens Q99816
Validated Y2H
25416956
Intra KIFC3 Q9BVG8 TSG101 Homo sapiens Q99816
Y2H Array
25416956
Intra KIFC3 Q9BVG8 NUP62 Homo sapiens P37198
Validated Y2H
25416956
Intra KIFC3 Q9BVG8 CCDC28A Homo sapiens Q8IWP9
Y2H Array
25416956
Intra KIFC3 Q9BVG8 TRAF2 Homo sapiens Q12933
Y2H Prey Pooling
25416956
Intra KIFC3 Q9BVG8 TRAF2 Homo sapiens Q12933
Validated Y2H
25416956
Intra KIFC3 Q9BVG8 MCM7 Homo sapiens P33993
Y2H Array
25416956
Intra KIFC3 Q9BVG8 MCM7 Homo sapiens P33993
Y2H Prey Pooling
25416956
Intra KIFC3 Q9BVG8 TNIP1 Homo sapiens Q15025
Y2H Prey Pooling
25416956
Intra KIFC3 Q9BVG8 PSMB1 Homo sapiens P20618
Y2H Array
31515488
Intra KIFC3 Q9BVG8 MED4 Homo sapiens Q9NPJ6
Y2H Array
25416956
Intra KIFC3 Q9BVG8 MED4 Homo sapiens Q9NPJ6
Y2H Prey Pooling
25416956
Intra KIFC3 Q9BVG8 SMARCE1 Homo sapiens Q969G3
Y2H Array
25416956
Intra KIFC3 Q9BVG8 SMARCE1 Homo sapiens Q969G3
Y2H
21516116
Intra KIFC3 Q9BVG8 SMARCE1 Homo sapiens Q969G3
Y2H Prey Pooling
25416956
Intra KIFC3 Q9BVG8 DTNBP1 Homo sapiens Q96EV8
Y2H Prey Pooling
25416956
Intra KIFC3 Q9BVG8 DTNBP1 Homo sapiens Q96EV8
Validated Y2H
25416956
Intra KIFC3 Q9BVG8 CLIP4 Homo sapiens Q8N3C7
Y2H Prey Pooling
25416956
Intra KIFC3 Q9BVG8 GOLGA2 Homo sapiens Q08379
Y2H Array
25416956
Intra KIFC3 Q9BVG8 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
25416956
Intra KIFC3 Q9BVG8 ZNF655 Homo sapiens Q8N720
Y2H Prey Pooling
25416956
Intra KIFC3 Q9BVG8 ZNF655 Homo sapiens Q8N720
Validated Y2H
25416956
Intra KIFC3 Q9BVG8 ZNF655 Homo sapiens Q8N720
Y2H Array
25416956
Intra KIFC3 Q9BVG8 SYCE1 Homo sapiens Q8N0S2
Y2H Prey Pooling
25416956
Intra KIFC3 Q9BVG8 KRT5 Homo sapiens P13647
Validated Y2H
25416956
Intra KIFC3 Q9BVG8 KRT5 Homo sapiens P13647
Y2H Array
25416956
Intra KIFC3 Q9BVG8 KRT6A Homo sapiens P02538
Validated Y2H
25416956
Intra KIFC3 Q9BVG8 KRT6A Homo sapiens P02538
Y2H Array
25416956
Intra KIFC3 Q9BVG8 ITGB3BP Homo sapiens Q13352
Validated Y2H
25416956
Intra KIFC3 Q9BVG8 CBX8 Homo sapiens Q9HC52
Y2H Prey Pooling
25416956
Intra KIFC3 Q9BVG8 CBX8 Homo sapiens Q9HC52
Validated Y2H
25416956
Intra KIFC3 Q9BVG8 PHC2 Homo sapiens Q8IXK0
Y2H Prey Pooling
25416956
Intra KIFC3 Q9BVG8 PHC2 Homo sapiens Q8IXK0
Y2H Array
25416956
Intra KIFC3 Q9BVG8 PHC2 Homo sapiens Q8IXK0
Validated Y2H
25416956
Intra KIFC3 Q9BVG8 DCTN2 Homo sapiens Q13561
Validated Y2H
25416956
Intra KIFC3 Q9BVG8 ZNF20 Homo sapiens P17024
Y2H Array
25416956
Intra KIFC3 Q9BVG8 ZNF20 Homo sapiens P17024
Validated Y2H
25416956
Intra KIFC3 Q9BVG8 TLE5 Homo sapiens Q08117
Y2H Prey Pooling
25416956
Intra KIFC3 Q9BVG8 TRIM27 Homo sapiens P14373
Validated Y2H
25416956
Intra KIFC3 Q9BVG8 TRIM27 Homo sapiens P14373
Y2H Array
25416956
Intra KIFC3 Q9BVG8 TRIM41 Homo sapiens Q8WV44
Validated Y2H
25416956
Intra KIFC3 Q9BVG8 LENG1 Homo sapiens Q96BZ8
Validated Y2H
25416956
Intra KIFC3 Q9BVG8 KRT15 Homo sapiens P19012
Y2H Array
25416956
Intra KIFC3 Q9BVG8 TRIM23 Homo sapiens P36406
Y2H Prey Pooling
25416956
Intra KIFC3 Q9BVG8 KANSL1 Homo sapiens Q7Z3B3
Y2H Array
31515488
Intra KIFC3 Q9BVG8 KRT6B Homo sapiens P04259
Validated Y2H
25416956
Intra KIFC3 Q9BVG8 KRT6B Homo sapiens P04259
Y2H Array
25416956
Intra KIFC3 Q9BVG8 LZTS2 Homo sapiens Q9BRK4
Y2H Prey Pooling
25416956
Intra KIFC3 Q9BVG8 CBY2 Homo sapiens Q8NA61
Validated Y2H
25416956
Intra KIFC3 Q9BVG8 CBY2 Homo sapiens Q8NA61
Y2H Prey Pooling
25416956
Intra KIFC3 Q9BVG8 ZBTB8A Homo sapiens Q96BR9
Y2H Prey Pooling
25416956
Intra KIFC3 Q9BVG8 ZBTB8A Homo sapiens Q96BR9
Y2H Array
25416956
Intra KIFC3 Q9BVG8 KRT19 Homo sapiens P08727
Y2H Array
25416956
Intra KIFC3 Q9BVG8 USP2 Homo sapiens O75604
Y2H Array
25416956
Intra KIFC3 Q9BVG8 CEP170P1 Homo sapiens Q96L14
Y2H Prey Pooling
25416956
Intra KIFC3 Q9BVG8 CEP170P1 Homo sapiens Q96L14
Validated Y2H
25416956
Intra KIFC3 Q9BVG8 ABI2 Homo sapiens Q9NYB9
Y2H Array
29892012
Intra KIFC3 Q9BVG8 CDK18 Homo sapiens Q07002
Validated Y2H
25416956
Intra KIFC3 Q9BVG8 TSR2 Homo sapiens Q969E8
Y2H Array
25416956
Intra KIFC3 Q9BVG8 TSR2 Homo sapiens Q969E8
Validated Y2H
25416956
Intra KIFC3 Q9BVG8 SIAH1 Homo sapiens Q8IUQ4
Validated Y2H
25416956
Intra KIFC3 Q9BVG8 SIAH1 Homo sapiens Q8IUQ4
Y2H Array
25416956
Intra KIFC3 Q9BVG8 SIAH1 Homo sapiens Q8IUQ4
Y2H Prey Pooling
25416956
Intra KIFC3 Q9BVG8 CEP55 Homo sapiens Q53EZ4
Y2H Array
25416956
Intra KIFC3 Q9BVG8 RSPH14 Homo sapiens Q9UHP6
Validated Y2H
25416956
Intra KIFC3 Q9BVG8 RSPH14 Homo sapiens Q9UHP6
Y2H Array
25416956
Intra KIFC3 Q9BVG8 DEUP1 Homo sapiens Q05D60
Y2H Array
25416956
Intra KIFC3 Q9BVG8 DEUP1 Homo sapiens Q05D60
Y2H Prey Pooling
25416956
Intra KIFC3 Q9BVG8 HSBP1 Homo sapiens O75506
Y2H Prey Pooling
25416956
Intra KIFC3 Q9BVG8 LIN37 Homo sapiens Q96GY3
Validated Y2H
25416956
Intra KIFC3 Q9BVG8 LIN37 Homo sapiens Q96GY3
Y2H Array
25416956
Intra KIFC3 Q9BVG8 SCEL Homo sapiens O95171
Y2H Array
25416956
Intra KIFC3 Q9BVG8 BCL6 Homo sapiens P41182
Y2H Prey Pooling
25416956
Intra KIFC3 Q9BVG8 BCL6 Homo sapiens P41182
Validated Y2H
25416956
Intra KIFC3 Q9BVG8 AIRIM Homo sapiens Q9NX04
Y2H Prey Pooling
25416956
Intra KIFC3 Q9BVG8 DCX Homo sapiens O43602
Y2H Array
25416956
Intra KIFC3 Q9BVG8 NDEL1 Homo sapiens Q9GZM8
Validated Y2H
25416956
Intra KIFC3 Q9BVG8 NDEL1 Homo sapiens Q9GZM8
Y2H Prey Pooling
25416956
Intra KIFC3 Q9BVG8 NDEL1 Homo sapiens Q9GZM8
Y2H Array
25416956
Intra KIFC3 Q9BVG8 KRT31 Homo sapiens Q15323
Validated Y2H
25416956
Intra KIFC3 Q9BVG8 KRT31 Homo sapiens Q15323
Y2H Array
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Retinitis Pigmentosa 63

RP63
Optic Atrophy 8

OPA8
Fanconi Anemia, Complementation Group C

Fanconi Anemia Complementation Group C

FANCC

Facc

Fac

Fa3

Fanconi Pancytopenia Type 3

Fanconi Pancytopenia, Type 3

Faces Syndrome

Facial Features , Anorexia, Cachexia, Eye And Skin Anomalies

Friedman-Goodman Syndrome

Abnormality Of The Face
Zellweger Syndrome

Cerebrohepatorenal Syndrome

Zellweger Leukodystrophy

Zs

Congenital Iron Overload

Chr

Zws

Severe Pbd-Zsd

Severe Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07300 KIFC3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris KIFC3 VGNC VGNC:42416
Rattus norvegicus KIFC3 RGD RGD:1307693
Felis catus KIFC3 VGNC VGNC:67947
Mus musculus KIFC3 MGD MGI:109202
Macaca mulatta KIFC3 VGNC VGNC:74022
Bos taurus KIFC3 VGNC VGNC:30613
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