TRIM23 - tripartite motif containing 23 Gene

中文名称：含三方基序 23

种属: Homo sapiens

同用名: ARD1; ARFD1; RNF46

关于 TRIM23

功能概要

由该基因编码的蛋白质是三联基序 (TRIM) 家族的成员。 TRIM 基序包括三个锌结合域、一个 RING、一个 B-box 类型 1 和一个 B-box 类型 2，以及一个卷曲螺旋区域。该蛋白也是鸟嘌呤核苷酸结合蛋白家族的 ADP 核糖基化因子家族的成员。它的羧基末端含有一个 ADP-核糖基化因子结构域和一个鸟嘌呤核苷酸结合位点，而氨基末端含有一个作用于鸟嘌呤核苷酸结合位点的 GTP 酶激活蛋白结构域。蛋白质定位于溶酶体和高尔基体。它在细胞内运输囊泡的形成、它们从一个隔室移动到另一个隔室以及磷脂酶 D 激活中发挥作用。已经描述了该基因的三种可变剪接转录物变体。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein is also a member of the ADP ribosylation factor family of guanine nucleotide-binding family of proteins. Its carboxy terminus contains an ADP-ribosylation factor domain and a guanine nucleotide binding site, while the amino terminus contains a GTPase activating protein domain which acts on the guanine nucleotide binding site. The protein localizes to lysosomes and the Golgi apparatus. It plays a role in the formation of intracellular transport vesicles, their movement from one compartment to another, and phopholipase D activation. Three alternatively spliced transcript variants for this gene have been described. [provided by RefSeq, Jul 2008]