1. Gene
  2. TACO1 - translational activator of cytochrome c oxidase I Gene

TACO1 - translational activator of cytochrome c oxidase I Gene

中文名称:细胞色素 c 氧化酶 I 的翻译激活因子

种属: Homo sapiens

同用名: CCDC44; MC4DN8

基因 ID: 51204 | 基因类型: protein coding

关于 TACO1

Cytogenetic location: 17q23.3 Genomic coordinates (GRCh38): 17:63,600,895-63,608,365 (from NCBI)

This gene has 4 transcripts (splice variants), 190 orthologues and is associated with 3 phenotypes. Ubiquitous expression in kidney (RPKM 17.5), liver (RPKM 13.0) and 25 other tissues.

功能概要

该基因编码一种线粒体蛋白,该蛋白充当线粒体编码的细胞色素 c 氧化酶 1 的翻译激活剂。该基因的突变与 Leigh 综合征有关。[RefSeq 提供,2010 年 3 月]

This gene encodes a mitochondrial protein that function as a translational activator of mitochondrially-encoded cytochrome c oxidase 1. Mutations in this gene are associated with Leigh syndrome.[provided by RefSeq, Mar 2010]

TACO1 基因产物(1)

mRNA Protein Name
NM_016360.4 NP_057444.2 translational activator of cytochrome c oxidase 1
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

TACO1 蛋白结构

Transcrip_reg

Transcrip_reg: Transcriptional regulator (61 - 297)

  • 0
  • 100
  • 200
  • 297 a.a.
蛋白主名 其他名称

translational activator of cytochrome c oxidase 1

clone HQ0477 PRO0477p

TACO1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra TACO1 Q9BSH4 KRT40 Homo sapiens Q6A162
Y2H Array
32296183
Intra TACO1 Q9BSH4 KRT40 Homo sapiens Q6A162
Y2H Prey Pooling
32296183
Intra TACO1 Q9BSH4 PPP1R16B Homo sapiens Q96T49
Y2H Array
32296183
Intra TACO1 Q9BSH4 PPP1R16B Homo sapiens Q96T49
Y2H Prey Pooling
32296183
Intra TACO1 Q9BSH4 KRT34 Homo sapiens O76011
Y2H Prey Pooling
32296183
Intra TACO1 Q9BSH4 KRT34 Homo sapiens O76011
Y2H Array
32296183
Intra TACO1 Q9BSH4 GTF3C3 Homo sapiens Q9Y5Q9
Validated Y2H
32814053
Intra TACO1 Q9BSH4 GTF3C3 Homo sapiens Q9Y5Q9
Y2H Pooling
32814053
Intra TACO1 Q9BSH4 GTF3C3 Homo sapiens Q9Y5Q9
Y2H Array
32814053
Intra TACO1 Q9BSH4 MTUS2 Homo sapiens Q5JR59-3
Y2H Array
32296183
Intra TACO1 Q9BSH4 MTUS2 Homo sapiens Q5JR59-3
Y2H Prey Pooling
32296183
Intra TACO1 Q9BSH4 CIB4 Homo sapiens A0PJX0
Y2H Array
32296183
Intra TACO1 Q9BSH4 CIB4 Homo sapiens A0PJX0
Y2H Prey Pooling
32296183
Intra TACO1 Q9BSH4 GOLGA6L9 Homo sapiens A6NEM1
Y2H Prey Pooling
32296183
Intra TACO1 Q9BSH4 GOLGA6L9 Homo sapiens A6NEM1
Y2H Array
32296183
Intra TACO1 Q9BSH4 SAT1 Homo sapiens P21673
Y2H Prey Pooling
32296183
Intra TACO1 Q9BSH4 SAT1 Homo sapiens P21673
Y2H Array
32296183
Intra TACO1 Q9BSH4 TRIM27 Homo sapiens P14373
Y2H Prey Pooling
32296183
Intra TACO1 Q9BSH4 TRIM27 Homo sapiens P14373
Y2H Array
32296183
Intra TACO1 Q9BSH4 MDFI Homo sapiens Q99750
Y2H Prey Pooling
32296183
Intra TACO1 Q9BSH4 MDFI Homo sapiens Q99750
Y2H Array
32296183
Intra TACO1 Q9BSH4 RINT1 Homo sapiens Q6NUQ1
Y2H Array
32296183
Intra TACO1 Q9BSH4 RINT1 Homo sapiens Q6NUQ1
Y2H Prey Pooling
32296183
Intra TACO1 Q9BSH4 CALCOCO2 Homo sapiens Q13137
Y2H Prey Pooling
32296183
Intra TACO1 Q9BSH4 CALCOCO2 Homo sapiens Q13137
Y2H Array
32296183
Intra TACO1 Q9BSH4 LNX1 Homo sapiens Q8TBB1
Y2H Prey Pooling
32296183
Intra TACO1 Q9BSH4 LNX1 Homo sapiens Q8TBB1
Y2H Array
32296183
Intra TACO1 Q9BSH4 TRIM23 Homo sapiens P36406
Y2H Array
32296183
Intra TACO1 Q9BSH4 TRIM23 Homo sapiens P36406
Y2H Prey Pooling
32296183
Intra TACO1 Q9BSH4 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
32296183
Intra TACO1 Q9BSH4 KRT31 Homo sapiens Q15323
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Mitochondrial Complex Iv Deficiency, Nuclear Type 8

MC4DN8

Mitochondrial Complex 4 Deficiency, Nuclear Type 8

Mitochondrial Complex Iv Deficiency, Nuclear Type 1

Cytochrome C Oxidase Deficiency

Mitochondrial Complex Iv Deficiency

Cox Deficiency

Cytochrome-C Oxidase Deficiency Disease

MC1DN4

Cytochrome-C Oxidase Deficiency

MC4DN1

Mitochondrial Complex I Deficiency, Nuclear Type 4

Complex 4 Mitochondrial Respiratory Chain Deficiency

Complex Iv Deficiency

Mitochondrial Complex 1 Deficiency, Nuclear Type 4

Nuclear Type Mitochondrial Complex I Deficiency 4

Deficiency Of Mitochondrial Respiratory Chain Complex4

MT-C4D

Complex Iv Mitochondrial Respiratory Chain Deficiency

Lethal Neonatal Cardiomyopathy Hypertrophic Due To Cytochrome C Oxidase Deficiency

Mitochondrial Complex Iv Deficiency, Nuclear, Type 1

Leigh Syndrome With Leukodystrophy

Infantile Subacute Necrotizing Encephalopathy With Leukodystrophy

Leigh Disease With Leukodystrophy

Charcot-Marie-Tooth Disease, Type 4k

Charcot-Marie-Tooth Disease Type 4k

CMT4K

Charcot-Marie-Tooth Disease, Demyelinating, Autosomal Recessive, Type 4k

Charcot-Marie-Tooth Neuropathy, Demyelinating, Autosomal Recessive, Type 4k

Surf1-Related Charcot-Marie-Tooth Disease Type 4

Surf1-Related Cmt4

Surf1-Related Severe Demyelinating Charcot-Marie-Tooth Disease

Autosomal Recessive Demyelinating Charcot-Marie-Tooth Disease Type 4k

Autosomal Recessive Demyelinating Charcot-Marie-Tooth Neuropathy Type 4k

Charcot-Marie-Tooth Disease 4k

Charcot-Marie-Tooth Disease, Demyelinating, Type 4k

Charcot-Marie-Tooth Neuropathy, Type 4k

Leigh Syndrome

Leigh Disease

Infantile Subacute Necrotizing Encephalopathy

Leigh Syndrome Due To Mitochondrial Complex Iv Deficiency

LS

Sne

Leigh'S Disease

Leigh Syndrome Due To Mitochondrial Complex I Deficiency

Necrotizing Encephalopathy, Infantile Subacute, Of Leigh

Subacute Necrotizing Encephalomyelopathy

Necrotizing Encephalopathy Infantile Subacute Of Leigh

Leigh Syndrome Due To Mitochondrial Complex Iii Deficiency

Infantile Necrotizing Encephalomyelopathy

Juvenile Subacute Necrotizing Encephalomyelopathy

Leigh'S Necrotizing Encephalopathy

Subacute Necrotizing Encephalopathy

Juvenile Subacute Necrotizing Encephalopathy

Leigh Syndrome Due To Mitochondrial Complex Ii Deficiency

Leigh Syndrome Due To Mitochondrial Complex V Deficiency

Encephalopathy, Subacute Necrotizing, Infantile

Encephalopathy, Subacute Necrotizing, Juvenile

Maternally Inherited Leigh Syndrome

Subacute Necrotising Encephalomyelopathy

Subacute Necrotising Encephalopathy

Charcot-Marie-Tooth Disease, Axonal, Type 2ee

CMT2EE

Charcot-Marie-Tooth Neuropathy, Type 2ee

Charcot-Marie-Tooth Disease Type 2ee

Charcot-Marie-Tooth Disease, Axonal, 2ee

Mitochondrial Complex Iv Deficiency, Nuclear Type 5

Leigh Syndrome, French Canadian Type

Mitochondrial Complex V Deficiency Nuclear Type 4

Cytochrome C Oxidase Deficiency, French Canadian Type

Lsfc

Cox Deficiency, French Canadian Type

MC5DN4

MC4DN5

Cox Deficiency, Saguenay-Lac-Saint-Jean Type

Leigh Syndrome, Saguenay-Lac-Saint-Jean Type

Mitochondrial Complex V Deficiency, Nuclear Type 4

French Canadian Leigh Disease

Leigh Syndrome, French-Canadian Type

Leigh Syndrome , French Canadian Type

Mitochondrial Complex V Deficiency, Atp5a1 Type

French Canadian Type Cox Deficiency

French Canadian Type Cytochrome C Oxidase Deficiency

French Canadian Type Leigh Syndrome

Saguenay Lac Saint Jean Type Cox Deficiency

Saguenay Lac Saint Jean Type Leigh Syndrome

Cox Deficiency, Saguenay Lac Saint Jean Type

Leigh Syndrome, Saguenay Lac Saint Jean Type

Mitochondrial Complex V Deficiency, Nuclear Type 4

Mitochondrial Complex V Deficiency Atp5a1 Type

Mitochondrial Complex V Deficiency Type 4

Mitochondrial Complex V Deficiency, Nuclear, Type 4

Mitochondrial Metabolism Disease

Abnormality Of Mitochondrial Metabolism

Mitochondrial Diseases

Pyruvate Dehydrogenase E1-Alpha Deficiency

Pyruvate Dehydrogenase Deficiency

Pyruvate Dehydrogenase Complex Deficiency

Pyruvate Decarboxylase Deficiency

Pdh Deficiency

PDHAD

Pyruvate Dehydrogenase Complex Deficiency Disease

Ataxia With Lactic Acidosis I

Ataxia With Lactic Acidosis 1

Pdh

Pdhc

Ataxia With Lactic Acidosis

Ataxia, Intermittent, With Abnormal Pyruvate Metabolism

Ataxia, Intermittent, With Pyruvate Dehydrogenase Deficiency

Deficiency Of Pyruvic Dehydrogenase

Ataxia, Intermittent, With Pyruvate Dehydrogenase, Or Decarboxylase, Deficiency

Pdc Deficiency

Intermittent Ataxia With Pyruvate Dehydrogenase Deficiency

Pdhc Deficiency

Pyruvate Dehydrogenase Complex E1 Component Subunit Alpha Deficiency

Ataxia Intermittent With Abnormal Pyruvate Metabolism

Ataxia Intermittent With Pyruvate Dehydrogenase Or Decarboxylase Deficiency

Pyruvate Dehydrogenase E1 Alpha Deficiency

Pdc - [Pyruvate Dehydrogenase Complex] Deficiency

Ataxia With Lactic Acidosis 2

Fatal Infantile Cardioencephalomyopathy Due To Cytochrome C Oxidase Deficiency

Cardioencephalomyopathy, Fatal Infantile, Due To Cytochrome C Oxidase Deficiency

Fatal Infantile Cox Deficiency

Fatal Infantile Cytochrome C Oxidase Deficiency

Fatal Infantile Encephalocardiomyopathy

Dystonia

Dystonic Disease

Dystonic Disorder

Dystonia Disorders

Neuroleptic Dyskinesia

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta TACO1 VGNC VGNC:104661
Mus musculus TACO1 MGD MGI:1917457
Bos taurus TACO1 VGNC VGNC:35559
Canis familiaris TACO1 VGNC VGNC:47065
Rattus norvegicus TACO1 RGD RGD:1306784
Felis catus TACO1 VGNC VGNC:99554