PPP1R16B - protein phosphatase 1 regulatory subunit 16B Gene

中文名称：蛋白磷酸酶 1 调节亚基 16B

种属: Homo sapiens

同用名: TIMAP; ANKRD4

基因 ID: 26051 | 基因类型: protein coding

关于 PPP1R16B

Cytogenetic location: 20q11.23 Genomic coordinates (GRCh38): 20:38,805,697-38,923,024 (from NCBI)

This gene has 4 transcripts (splice variants), 204 orthologues and 1 paralogue. Broad expression in lymph node (RPKM 19.5), brain (RPKM 18.4) and 18 other tissues.

功能概要

该基因编码的蛋白质与膜相关，包含五个锚蛋白重复序列、一个蛋白磷酸酶 1 相互作用结构域和一个羧基末端 CAAX 框结构域。编码蛋白的合成受到转化生长因子 β-1 的抑制。该蛋白质可通过其 CAAX 盒结构域与膜结合，并可通过与蛋白磷酸酶-1 的相互作用充当信号分子。选择性剪接导致编码不同亚型的多个转录变体，这些亚型可能经历类似的加工以产生成熟蛋白质。[RefSeq 提供，2015 年 9 月]

The protein encoded by this gene is membrane-associated and contains five ankyrin repeats, a protein phosphatase-1-interacting domain, and a carboxy-terminal CAAX box domain. Synthesis of the encoded protein is inhibited by transforming growth factor beta-1. The protein may bind to the membrane through its CAAX box domain and may act as a signaling molecule through interaction with protein phosphatase-1. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Sep 2015]

PPP1R16B 基因产物(2)

mRNA	Protein	Name
NM_001172735.3	NP_001166206.1	protein phosphatase 1 regulatory inhibitor subunit 16B isoform 2
NM_015568.4	NP_056383.1	protein phosphatase 1 regulatory inhibitor subunit 16B isoform 1 precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	16263087	GOA
enables protein phosphatase regulator activity	IDA IDA: 通过直接分析推断	16263087	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in establishment of endothelial barrier	IMP IMP: 通过突变表型推断	18586956	GOA
involved in positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	IMP IMP: 通过突变表型推断	25007873	GOA
involved in positive regulation of endothelial cell proliferation	IMP IMP: 通过突变表型推断	25007873	GOA
involved in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: 通过突变表型推断	25007873	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cell projection	IDA IDA: 通过直接分析推断	25007873	GOA
located in nucleus	IDA IDA: 通过直接分析推断	12055102	GOA
located in perinuclear region of cytoplasm	IDA IDA: 通过直接分析推断	12055102	GOA
located in plasma membrane	IDA IDA: 通过直接分析推断	12055102	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PPP1R16B 蛋白结构

Ank_2

0
100
200
300
400
500
567 a.a.

蛋白主名

其他名称

protein phosphatase 1 regulatory inhibitor subunit 16B

CAAX box protein TIMAP

PPP1R16B 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	PPP1R16B	Q96T49	TASOR2	Homo sapiens	Q5VWN6-2	Y2H Array	25416956
Intra	PPP1R16B	Q96T49	NEFL	Homo sapiens	I6L9F6	Y2H Prey Pooling	25416956
Intra	PPP1R16B	Q96T49	NEFL	Homo sapiens	I6L9F6	Validated Y2H	25416956
Intra	PPP1R16B	Q96T49	ZNF564	Homo sapiens	Q8TBZ8	Anti Tag CoIP	28514442
Intra	PPP1R16B	Q96T49	ZNF564	Homo sapiens	Q8TBZ8	Anti Tag CoIP	33961781
Intra	PPP1R16B	Q96T49	PATZ1	Homo sapiens	Q9HBE1-4	Validated Y2H	32296183
Intra	PPP1R16B	Q96T49	ZNF410	Homo sapiens	Q86VK4-3	Validated Y2H	27107012
Intra	PPP1R16B	Q96T49	ZNF410	Homo sapiens	Q86VK4-3	BFG-2H	27107012
Intra	PPP1R16B	Q96T49	HAPLN2	Homo sapiens	Q9GZV7	Validated Y2H	32296183
Intra	PPP1R16B	Q96T49	TXN2	Homo sapiens	Q99757	Validated Y2H	32296183
Intra	PPP1R16B	Q96T49	SF3B4	Homo sapiens	Q15427	Validated Y2H	25416956
Intra	PPP1R16B	Q96T49	SF3B4	Homo sapiens	Q15427	Y2H Prey Pooling	25416956
Intra	PPP1R16B	Q96T49	SF3B4	Homo sapiens	Q15427	Y2H Array	25416956
Intra	PPP1R16B	Q96T49	PPP1CB	Homo sapiens	P62140	Anti Tag CoIP	33961781
Intra	PPP1R16B	Q96T49	PPP1CB	Homo sapiens	P62140	Anti Tag CoIP	28514442
Intra	PPP1R16B	Q96T49	PPP1CB	Homo sapiens	P62140	BioID	28330616
Intra	PPP1R16B	Q96T49	PPP1CB	Homo sapiens	P62140	Pull Down	28330616
Intra	PPP1R16B	Q96T49	PPP1CB	Homo sapiens	P62140	Validated Y2H	27107012
Intra	PPP1R16B	Q96T49	PPP1CA	Homo sapiens	P62136	Anti Tag CoIP	33961781
Intra	PPP1R16B	Q96T49	PPP1CA	Homo sapiens	P62136	Anti Tag CoIP	28514442
Intra	PPP1R16B	Q96T49	KCTD9	Homo sapiens	Q7L273	Y2H Array	25416956
Intra	PPP1R16B	Q96T49	HTRA2	Homo sapiens	O43464	Validated Y2H	32814053
Intra	PPP1R16B	Q96T49	HTRA2	Homo sapiens	O43464	Y2H Array	32814053
Intra	PPP1R16B	Q96T49	HTRA2	Homo sapiens	O43464	Y2H Pooling	32814053
Intra	PPP1R16B	Q96T49	GOLGA2	Homo sapiens	Q08379	Y2H Array	25416956
Intra	PPP1R16B	Q96T49	GOLGA2	Homo sapiens	Q08379	Validated Y2H	27107012
Intra	PPP1R16B	Q96T49	GOLGA2	Homo sapiens	Q08379	BFG-2H	27107012
Intra	PPP1R16B	Q96T49	PHC2	Homo sapiens	Q8IXK0	Y2H Array	25416956
Intra	PPP1R16B	Q96T49	PHC2	Homo sapiens	Q8IXK0	Y2H Prey Pooling	25416956
Intra	PPP1R16B	Q96T49	CEP70	Homo sapiens	Q8NHQ1	Y2H Prey Pooling	25416956
Intra	PPP1R16B	Q96T49	CEP70	Homo sapiens	Q8NHQ1	Validated Y2H	25416956
Intra	PPP1R16B	Q96T49	IKZF3	Homo sapiens	Q9UKT9	Y2H Array	25416956
Intra	PPP1R16B	Q96T49	IKZF3	Homo sapiens	Q9UKT9	BFG-2H	27107012
Intra	PPP1R16B	Q96T49	IKZF3	Homo sapiens	Q9UKT9	Y2H Array	31515488
Intra	PPP1R16B	Q96T49	IKZF3	Homo sapiens	Q9UKT9	Y2H Prey Pooling	25416956
Intra	PPP1R16B	Q96T49	CEP55	Homo sapiens	Q53EZ4	Validated Y2H	27107012
Intra	PPP1R16B	Q96T49	CEP55	Homo sapiens	Q53EZ4	BFG-2H	27107012
Intra	PPP1R16B	Q96T49	CEP55	Homo sapiens	Q53EZ4	Y2H Array	25416956
Intra	PPP1R16B	Q96T49	TACO1	Homo sapiens	Q9BSH4	Validated Y2H	32296183
Intra	PPP1R16B	Q96T49	CRX	Homo sapiens	O43186	Y2H Prey Pooling	25416956
Intra	PPP1R16B	Q96T49	CRX	Homo sapiens	O43186	Validated Y2H	25416956
Intra	PPP1R16B	Q96T49	SCNM1	Homo sapiens	Q9BWG6	Validated Y2H	32296183
Intra	PPP1R16B	Q96T49	PRPH	Homo sapiens	P41219	Validated Y2H	32814053
Intra	PPP1R16B	Q96T49	PRPH	Homo sapiens	P41219	Y2H Pooling	32814053
Intra	PPP1R16B	Q96T49	PRPH	Homo sapiens	P41219	Y2H Array	32814053

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Ciliary Dyskinesia, Primary, 19

Primary Ciliary Dyskinesia 19	CILD19
Primary Ciliary Dyskinesia 19 With Or Without Situs Inversus	Ciliary Dyskinesia, Primary, 19, With Or Without Situs Inversus
Ics19	Immotile Cilia Syndrome 19
Dyskinesia, Ciliary, Primary, 19

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS10989	PPP1R16B Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	PPP1R16B	VGNC	VGNC:97123
Mus musculus	PPP1R16B	MGD	MGI:2151841
Canis familiaris	PPP1R16B	VGNC	VGNC:44885
Bos taurus	PPP1R16B	VGNC	VGNC:33231
Rattus norvegicus	PPP1R16B	RGD	RGD:1589460
Felis catus	PPP1R16B	VGNC	VGNC:64321

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

PPP1R16B - protein phosphatase 1 regulatory subunit 16B Gene

关于 PPP1R16B

功能概要

PPP1R16B 基因产物(2)

PPP1R16B 蛋白结构

PPP1R16B 蛋白互作信息

关联疾病

直系同源

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PPP1R16B - protein phosphatase 1 regulatory subunit 16B Gene

关于 PPP1R16B

功能概要

PPP1R16B 基因产物(2)

PPP1R16B 蛋白结构

PPP1R16B 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z