1. Gene
  2. PPP1CB - protein phosphatase 1 catalytic subunit beta Gene

PPP1CB - protein phosphatase 1 catalytic subunit beta Gene

中文名称:蛋白磷酸酶 1 催化亚基 β

种属: Homo sapiens

同用名: MP; PP1B; PP1c; NSLH2; PP-1B; PPP1CD; PP1beta; PPP1beta; HEL-S-80p

基因 ID: 5500 | 基因类型: protein coding

关于 PPP1CB

Cytogenetic location: 2p23.2 Genomic coordinates (GRCh38): 2:28,751,604-28,802,940 (from NCBI)

This gene has 16 transcripts (splice variants), 213 orthologues, 12 paralogues and is associated with 3 phenotypes. Ubiquitous expression in esophagus (RPKM 80.9), prostate (RPKM 58.5) and 25 other tissues.

功能概要

该基因编码的蛋白质是蛋白磷酸酶 1 (PP1) 的三个催化亚基之一。 PP1 是一种丝氨酸/苏氨酸特异性蛋白磷酸酶,已知参与多种细胞过程的调节,例如细胞分裂、糖原代谢、肌肉收缩性、蛋白质合成和 HIV-1 病毒转录。小鼠研究表明,PP1 可抑制学习和记忆。已观察到编码不同同种型的两种选择性剪接的转录物变体。[RefSeq 提供,2008 年 7 月]

The protein encoded by this gene is one of the three catalytic subunits of protein Phosphatase 1 (PP1). PP1 is a serine/threonine specific protein Phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Mouse studies suggest that PP1 functions as a suppressor of learning and memory. Two alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

PPP1CB 基因产物(2)

mRNA Protein Name
NM_002709.3 NP_002700.1 serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform 1
NM_206876.2 NP_996759.1 serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables myosin-light-chain-phosphatase activity IDA
IDA: 通过直接分析推断
20354225 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
11067852 GOA
enables protein kinase binding IPI
IPI: 通过物理相互作用推断
20354225 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in regulation of cell adhesion IDA
IDA: 通过直接分析推断
20354225 GOA
involved in regulation of circadian rhythm IMP
IMP: 通过突变表型推断
21712997 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of PTW/PP1 phosphatase complex IDA
IDA: 通过直接分析推断
20354225 GOA
colocalizes with chromosome, telomeric region IDA
IDA: 通过直接分析推断
24270157 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

PPP1CB 蛋白结构

Metallophos

Metallophos: Calcineurin-like phosphoesterase (58 - 249)

  • 0
  • 100
  • 200
  • 300
  • 327 a.a.
蛋白主名 其他名称

serine/threonine-protein phosphatase PP1-beta catalytic subunit

epididymis secretory sperm binding protein Li 80p

PPP1CB 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PPP1CB P62140 PPP1R7 Homo sapiens Q15435
BioID
28330616
种属内
PPP1CB P62140 PPP1R7 Homo sapiens Q15435
Anti Bait CoIP
17353931
种属内
PPP1CB P62140 PPP1R7 Homo sapiens Q15435
Pull Down
28330616
种属内
PPP1CB P62140 PPP1R7 Homo sapiens Q15435
TAP
27173435
种属内
PPP1CB P62140 PPP1R7 Homo sapiens Q15435
Anti Tag CoIP
26496610
种属内
PPP1CB P62140 PPP1R7 Homo sapiens Q15435
Anti Tag CoIP
27880917
种属内
PPP1CB P62140 PPP1R7 Homo sapiens Q15435
Validated Y2H
32296183
种属内
PPP1CB P62140 PPP1R2B Homo sapiens Q6NXS1
Validated Y2H
25416956
种属内
PPP1CB P62140 PPP1R2B Homo sapiens Q6NXS1
Validated Y2H
32296183
种属内
PPP1CB P62140 PPP1R2B Homo sapiens Q6NXS1
Y2H Array
25416956
种属内
PPP1CB P62140 PPP1R2B Homo sapiens Q6NXS1
Y2H Prey Pooling
32296183
种属内
PPP1CB P62140 PPP1R16B Homo sapiens Q96T49
BFG-2H
27107012
种属内
PPP1CB P62140 PPP1R11 Homo sapiens O60927
Anti Tag CoIP
27880917
种属内
PPP1CB P62140 PPP1R11 Homo sapiens O60927
Anti Tag CoIP
26496610
种属内
PPP1CB P62140 PPP1R11 Homo sapiens O60927
TAP
27173435
种属内
PPP1CB P62140 PPP1R11 Homo sapiens O60927
Anti Bait CoIP
17353931
种属内
PPP1CB P62140 PPP1R11 Homo sapiens O60927
BioID
28330616
种属内
PPP1CB P62140 PPP1R11 Homo sapiens O60927
Pull Down
28330616
种属内
PPP1CB P62140 TP53BP2 Homo sapiens Q05BL1
Validated Y2H
32296183
种属内
PPP1CB P62140 TP53BP2 Homo sapiens Q05BL1
Y2H Array
32296183
种属内
PPP1CB P62140 TP53BP2 Homo sapiens Q05BL1
Y2H Prey Pooling
32296183
种属内
PPP1CB P62140 SPATC1L Homo sapiens Q9H0A9-2
Validated Y2H
32296183
种属内
PPP1CB P62140 NRAC Homo sapiens Q8N912
Validated Y2H
32296183
种属内
PPP1CB P62140 PPP1R12B Homo sapiens A0A0S2Z4Q8
Y2H Prey Pooling
26871637
种属内
PPP1CB P62140 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
种属内
PPP1CB P62140 MEOX2 Homo sapiens Q6FHY5
Validated Y2H
32296183
种属内
PPP1CB P62140 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
种属内
PPP1CB P62140 PPP1R3C Homo sapiens Q9UQK1
Y2H Prey Pooling
25416956
种属内
PPP1CB P62140 PPP1R3C Homo sapiens Q9UQK1
Validated Y2H
25416956
种属内
PPP1CB P62140 PPP1R3C Homo sapiens Q9UQK1
Y2H Prey Pooling
32296183
种属内
PPP1CB P62140 PPP1R3C Homo sapiens Q9UQK1
Validated Y2H
32296183
种属内
PPP1CB P62140 PPP1R3C Homo sapiens Q9UQK1
Y2H Array
32296183
种属内
PPP1CB P62140 KANK2 Homo sapiens Q63ZY3
Validated Y2H
32296183
种属内
PPP1CB P62140 KANK2 Homo sapiens Q63ZY3
Y2H Array
32296183
种属内
PPP1CB P62140 KANK2 Homo sapiens Q63ZY3
Y2H Prey Pooling
32296183
种属内
PPP1CB P62140 PPP1R9B Homo sapiens Q96SB3
Anti Tag CoIP
26496610
种属内
PPP1CB P62140 RRP1B Homo sapiens Q14684
TAP
27173435
种属内
PPP1CB P62140 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
种属内
PPP1CB P62140 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
种属内
PPP1CB P62140 CSRNP1 Homo sapiens Q96S65
Y2H Array
32296183
种属内
PPP1CB P62140 CSRNP1 Homo sapiens Q96S65
Y2H Prey Pooling
32296183
种属内
PPP1CB P62140 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32814053
种属内
PPP1CB P62140 SPRED1 Homo sapiens Q7Z699
Y2H Array
32814053
种属内
PPP1CB P62140 SPRED1 Homo sapiens Q7Z699
Y2H Pooling
32814053
种属内
PPP1CB P62140 PPP1R27 Homo sapiens Q86WC6
Validated Y2H
32296183
种属内
PPP1CB P62140 CSRNP2 Homo sapiens Q9H175
Y2H Prey Pooling
32296183
种属内
PPP1CB P62140 CSRNP2 Homo sapiens Q9H175
Complementation
32296183
种属内
PPP1CB P62140 CSRNP2 Homo sapiens Q9H175
Y2H Array
25416956
种属内
PPP1CB P62140 CSRNP2 Homo sapiens Q9H175
Y2H Array
32296183
种属内
PPP1CB P62140 CSRNP2 Homo sapiens Q9H175
Validated Y2H
32296183
种属内
PPP1CB P62140 CSRNP2 Homo sapiens Q9H175
Validated Y2H
25416956
种属内
PPP1CB P62140 PPP1R13L Homo sapiens Q8WUF5
TAP
27173435
种属内
PPP1CB P62140 PPP1R13L Homo sapiens Q8WUF5
BioID
28330616
种属内
PPP1CB P62140 PPP1R13L Homo sapiens Q8WUF5
Pull Down
28330616
种属内
PPP1CB P62140 PPP1R13L Homo sapiens Q8WUF5
Anti Tag CoIP
27880917
种属内
PPP1CB P62140 PPP1R13L Homo sapiens Q8WUF5
Anti Tag CoIP
26496610
种属内
PPP1CB P62140 PPP1R16A Homo sapiens Q96I34
Pull Down
28330616
种属内
PPP1CB P62140 PPP1R16A Homo sapiens Q96I34
Y2H Array
25416956
种属内
PPP1CB P62140 PPP1R16A Homo sapiens Q96I34
Validated Y2H
25416956
种属内
PPP1CB P62140 PPP1R16A Homo sapiens Q96I34
Validated Y2H
32296183
种属内
PPP1CB P62140 PHACTR3 Homo sapiens Q96KR7
Validated Y2H
32296183
种属内
PPP1CB P62140 CHCHD3 Homo sapiens Q9NX63
Y2H Prey Pooling
32296183
种属内
PPP1CB P62140 CHCHD3 Homo sapiens Q9NX63
Validated Y2H
32296183
种属内
PPP1CB P62140 CHCHD3 Homo sapiens Q9NX63
Y2H Array
32296183
种属内
PPP1CB P62140 SH2D4A Homo sapiens Q9H788
BFG-2H
27107012
种属内
PPP1CB P62140 SH2D4A Homo sapiens Q9H788
Anti Bait CoIP
17353931
种属内
PPP1CB P62140 SH2D4A Homo sapiens Q9H788
Pull Down
28330616
种属内
PPP1CB P62140 SH2D4A Homo sapiens Q9H788
Validated Y2H
27107012
种属内
PPP1CB P62140 SH2D4A Homo sapiens Q9H788
Y2H Prey Pooling
25416956
种属内
PPP1CB P62140 SH2D4A Homo sapiens Q9H788
Anti Tag CoIP
27880917
种属内
PPP1CB P62140 SH2D4A Homo sapiens Q9H788
Anti Tag CoIP
26496610
种属内
PPP1CB P62140 SH2D4A Homo sapiens Q9H788
BioID
28330616
种属内
PPP1CB P62140 SH2D4A Homo sapiens Q9H788
Validated Y2H
32296183
种属内
PPP1CB P62140 SH2D4A Homo sapiens Q9H788
TAP
27173435
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Noonan Syndrome-Like Disorder With Loose Anagen Hair 2

NSLH2

Noonan Syndrome-Like Disorder With Loose Anagen Hair

Noonan-Like Syndrome With Loose Anagen Hair

Mazzanti Syndrome

Ns/Lah

Pseudo-Turner Syndrome

Noonan Syndrome

Noonan Syndrome 1

Noonan Syndrome

NS1

Male Turner Syndrome

Female Pseudo-Turner Syndrome

Turner Phenotype With Normal Karyotype

Noonan Syndrome With Pigmented Villonodular Synovitis

Turner'S Phenotype, Karyotype Normal

Familial Turner Syndrome

Noonan'S Syndrome

Noonan-Ehmke Syndrome

Ns

Pseudo-Ullrich-Turner Syndrome

Turner Syndrome In Female With X Chromosome

Turner-Like Syndrome

Ullrich-Noonan Syndrome

Noonan-Like/Multiple Giant Cell Lesion Syndrome

Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions

Pterygium Colli Syndrome

Noonan Syndrome, Type 1

Turner Syndrome, Male

Dandy-Walker Syndrome

Dandy-Walker Malformation

DWS

Atresia Of Foramina Of Magendie And Luschka

Dandy-Walker Complex

Dandy-Walker Cyst

Dandy-Walker Deformity

Dandy Walker Cyst

Dw Complex

Dandy-Walker Syndrome Or Malformation

Dandy-Walker Variant

Mega Cisterna Magna

Dwm

Hydrocephalus, Internal, Dandy-Walker Type

Hydrocephalus, Noncommunicating, Dandy-Walker Type

Luschka-Magendie Foramina Atresia

Isolated Dandy-Walker Malformation

Mega-Cisterna Magna

Dandy Walker Variant

Atresia Of Foramen Of Luschka

Atresia Of Foramen Of Magendie

Congenital Blockage Of Foramen Magendie

Rheumatoid Arthritis

RA

Arthritis, Rheumatoid

Rheumatoid Arthritis, Susceptibility To

Arthritis Or Polyarthritis, Rheumatic

Atrophic Arthritis

Rheumatism Arthritis

Rheumatoid Polyarthritis

Neurofibromatosis-Noonan Syndrome

NFNS

Neurofibromatosis Type 1

Neurofibromatosis With Noonan Phenotype

Nf1

Von Recklinghausen Disease

Neurofibromatosis Type 1-Noonan Syndrome

Noonan Neurofibromatosis Syndrome

Recklinghausen'S Disease

Noonan-Neurofibromatosis Syndrome

Fibromatosis Multiple Non Ossifying

Disseminated Nonossifying Fibromas In Association With Cafe-Au-Lait Spots

Jaffe Campanacci Syndrome

Type 1 Neurofibromatosis

Neurofibromatosis 1

Peripheral Neurofibromatosis

Recklinghausen Disease, Nerve

Jaffe-Campanacci Syndrome

Rasopathy

Ras/Mitogen-Activated Protein Kinase Syndrome

Cardiofaciocutaneous Syndrome 1

Cardiofaciocutaneous Syndrome

Cfc Syndrome

Cardio-Facio-Cutaneous Syndrome

CFC1

Cfcs

Cardio-Facial-Cutaneous Syndrome

Congenital Heart Defects Characteristic Facial Appearance Ectodermal Abnormalities And Growth Failure

Cardiofaciocutaneous Syndrome, Type 1

Ptosis

Blepharoptosis

Drooping Eyelid

Droopy Eyelid

Ptosis Of Eyelid

Paralysis Of Levator Palpebrae Superioris

Noonan Syndrome With Multiple Lentigines

Leopard Syndrome

Multiple Lentigines Syndrome

Moynahan Syndrome

Cardiomyopathic Lentiginosis

Progressive Cardiomyopathic Lentiginosis

Cardio-Cutaneous Syndrome

Lentiginosis Profusa

Capute-Rimoin-Konigsmark-Esterly-Richardson Syndrome

Generalized Lentiginosis

Gorlin Syndrome Ii

Lentiginosis Profusa Syndrome

Lentigines, Electrocardiographic Conduction Abnormalities, Ocular Hypertelorism, Pulmonic Stenosis, Abnormal Genitalia, Retardation Of Growth, Deafnes

Diffuse Lentiginosis

Nsml

Familial Multiple Lentigines Syndrome

Alopecia-Epilepsy-Intellectual Disability Syndrome, Moynahan Type

Progressive Cardiomyopathic Lentiginosis Syndrome

Alopecia Epilepsy Oligophrenia Syndrome Of Moynahan

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus PPP1CB RGD RGD:3376
Canis familiaris PPP1CB VGNC VGNC:44875
Macaca mulatta PPP1CB VGNC VGNC:106197
Felis catus PPP1CB VGNC VGNC:68998
Mus musculus PPP1CB MGD MGI:104871
Bos taurus PPP1CB VGNC VGNC:33220
Others PPP1CB NCBI