CSRNP1 - cysteine and serine rich nuclear protein 1 Gene

中文名称：富半胱氨酸和丝氨酸的核蛋白 1

种属: Homo sapiens

同用名: AXUD1; URAX1; TAIP-3; CSRNP-1; FAM130B

关于 CSRNP1

功能概要

该基因编码一种定位于细胞核的蛋白质，并且该基因的表达被诱导以响应升高的轴蛋白水平。受轴蛋白负调控的 Wnt 信号通路在早期发育的轴形成中很重要，并且该信号通路的调节受损通常与肿瘤有关。与其相应的正常组织中的表达水平相比，该基因在肿瘤中的表达水平降低表明该基因产物具有肿瘤抑制功能。可变剪接导致多个转录本变体。[RefSeq 提供，2016 年 2 月]

This gene encodes a protein that localizes to the nucleus and expression of this gene is induced in response to elevated levels of axin. The Wnt signalling pathway, which is negatively regulated by axin, is important in axis formation in early development and impaired regulation of this signalling pathway is often involved in tumors. A decreased level of expression of this gene in tumors compared to the level of expression in their corresponding normal tissues suggests that this gene product has a tumor suppressor function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]