PPP1CA - protein phosphatase 1 catalytic subunit alpha Gene

中文名称：蛋白磷酸酶 1 催化亚基 α

种属: Homo sapiens

同用名: PP1A; PP-1A; PPP1A; PP1alpha

基因 ID: 5499 | 基因类型: protein coding

关于 PPP1CA

Cytogenetic location: 11q13.2 Genomic coordinates (GRCh38): 11:67,398,183-67,401,858 (from NCBI)

This gene has 14 transcripts (splice variants), 177 orthologues and 12 paralogues. Ubiquitous expression in lymph node (RPKM 67.2), colon (RPKM 56.9) and 25 other tissues.

功能概要

该基因编码的蛋白质是蛋白磷酸酶 1 (PP1) 的三个催化亚基之一。这种广泛表达的基因编码 PP1 复合体的 α 亚基，该复合体与 200 多种调节蛋白结合形成全酶，以高特异性去磷酸化其生物靶标。 PP1 是一种丝氨酸/苏氨酸特异性蛋白磷酸酶，已知参与多种细胞过程的调节，例如细胞分裂、糖原代谢、肌肉收缩性、蛋白质合成和 HIV-1 病毒转录。在心力衰竭末期观察到 PP1 活性增加。研究表明，PP1 是心脏功能的重要调节因子，PP1 失调与糖尿病和多种癌症有关。已经为该基因发现了编码不同同种型的三种选择性剪接的转录物变体。[RefSeq 提供，2020 年 7 月]

The protein encoded by this gene is one of the three catalytic subunits of protein Phosphatase 1 (PP1). This broadly expressed gene encodes the alpha subunit of the PP1 complex that associates with over 200 regulatory proteins to form holoenzymes which dephosphorylate their biological targets with high specificity. PP1 is a serine/threonine specific protein Phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies suggest that PP1 is an important regulator of cardiac function and that PP1 deregulation is implicated in diabetes and multiple types of Cancer. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2020]

PPP1CA 基因产物(3)

mRNA	Protein	Name
NM_001008709.2	NP_001008709.1	serine/threonine-protein phosphatase PP1-alpha catalytic subunit isoform 3
NM_002708.4	NP_002699.1	serine/threonine-protein phosphatase PP1-alpha catalytic subunit isoform 1
NM_206873.2	NP_996756.1	serine/threonine-protein phosphatase PP1-alpha catalytic subunit isoform 2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables cadherin binding involved in cell-cell adhesion	IDA IDA: 通过直接分析推断	25468996	GOA
enables iron ion binding	IDA IDA: 通过直接分析推断	30403291	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	10807923	GOA
enables protein serine/threonine phosphatase activity	IDA IDA: 通过直接分析推断	28216226	GOA
enables transition metal ion binding	IDA IDA: 通过直接分析推断	30403291	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in dephosphorylation	IDA IDA: 通过直接分析推断	22311981	GOA
acts upstream of or within protein dephosphorylation	IMP IMP: 通过突变表型推断	22801782	GOA
involved in protein dephosphorylation	IMP IMP: 通过突变表型推断	22311981	GOA
involved in regulation of circadian rhythm	IMP IMP: 通过突变表型推断	21712997	GOA
involved in telomere maintenance in response to DNA damage	IDA IDA: 通过直接分析推断	28216226	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of PTW/PP1 phosphatase complex	IDA IDA: 通过直接分析推断	20516061	GOA
located in adherens junction	IDA IDA: 通过直接分析推断	25468996	GOA
colocalizes with chromosome, telomeric region	IDA IDA: 通过直接分析推断	24270157	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	11739654	GOA
located in nucleus	IDA IDA: 通过直接分析推断	11739654	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PPP1CA 蛋白结构

Metallophos

0
100
200
300
330 a.a.

蛋白主名

其他名称

serine/threonine-protein phosphatase PP1-alpha catalytic subunit

protein phosphatase 1, catalytic subunit, alpha isozyme

PPP1CA 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	PPP1CA	P62136	KNL1	Homo sapiens	Q8NG31	Anti Tag CoIP	33961781
种属内	PPP1CA	P62136	PPP1R7	Homo sapiens	Q15435	TAP	27173435
种属内	PPP1CA	P62136	PPP1R7	Homo sapiens	Q15435	Anti Bait CoIP	25593058
种属内	PPP1CA	P62136	PPP1R7	Homo sapiens	Q15435	BioID	28330616
种属内	PPP1CA	P62136	PPP1R7	Homo sapiens	Q15435	Pull Down	28330616
种属内	PPP1CA	P62136	PPP1R2B	Homo sapiens	Q6NXS1	Y2H Prey Pooling	25416956
种属内	PPP1CA	P62136	PPP1R16B	Homo sapiens	Q96T49	Y2H Array	32296183
种属内	PPP1CA	P62136	PPP1R16B	Homo sapiens	Q96T49	Validated Y2H	32296183
种属内	PPP1CA	P62136	PPP1R16B	Homo sapiens	Q96T49	Y2H Prey Pooling	32296183
种属内	PPP1CA	P62136	PPP1R3D	Homo sapiens	O95685	Pull Down	28330616
种属内	PPP1CA	P62136	PPP1R3D	Homo sapiens	O95685	Anti Tag CoIP	33961781
种属内	PPP1CA	P62136	PPP1R3D	Homo sapiens	O95685	Anti Tag CoIP	28514442
种属内	PPP1CA	P62136	EIF2S1	Homo sapiens	P05198	Phosphatase Assay	26095357
种属内	PPP1CA	P62136	EIF2S1	Homo sapiens	P05198	BiFC	26095357
种属内	PPP1CA	P62136	PPP1R2	Homo sapiens	P41236	Filter Binding	10807923
种属内	PPP1CA	P62136	PPP1R2	Homo sapiens	P41236	Anti Tag CoIP	28514442
种属内	PPP1CA	P62136	PPP1R2	Homo sapiens	P41236	NMR	20826336
种属内	PPP1CA	P62136	PPP1R2	Homo sapiens	P41236	GMS	20826336
种属内	PPP1CA	P62136	PPP1R2	Homo sapiens	P41236	SAXS	20826336
种属内	PPP1CA	P62136	PPP1R2	Homo sapiens	P41236	BioID	28330616
种属内	PPP1CA	P62136	PPP1R2	Homo sapiens	P41236	Pull Down	28330616
种属内	PPP1CA	P62136	PPP1R2	Homo sapiens	P41236	Pull Down	20826336
种属内	PPP1CA	P62136	PPP1R2	Homo sapiens	P41236	Anti Bait CoIP	25593058
种属内	PPP1CA	P62136	PPP1R2	Homo sapiens	P41236	Anti Tag CoIP	33961781
种属内	PPP1CA	P62136	PPP1R2	Homo sapiens	P41236	TAP	27173435
种属内	PPP1CA	P62136	PPP1R13B	Homo sapiens	Q96KQ4	Anti Tag CoIP	28514442
种属内	PPP1CA	P62136	PPP1R13B	Homo sapiens	Q96KQ4	Validated Y2H	32296183
种属内	PPP1CA	P62136	PPP1R13B	Homo sapiens	Q96KQ4	Y2H Array	32296183
种属内	PPP1CA	P62136	PPP1R13B	Homo sapiens	Q96KQ4	Pull Down	28330616
种属内	PPP1CA	P62136	PPP1R13B	Homo sapiens	Q96KQ4	Y2H	15231748
种属内	PPP1CA	P62136	PPP1R13B	Homo sapiens	Q96KQ4	BioID	28330616
种属内	PPP1CA	P62136	PPP1R13B	Homo sapiens	Q96KQ4	Anti Tag CoIP	33961781
种属内	PPP1CA	P62136	PPP1R13B	Homo sapiens	Q96KQ4	Y2H Prey Pooling	32296183
种属内	PPP1CA	P62136	TP53BP2	Homo sapiens	Q05BL1	Y2H Prey Pooling	32296183
种属内	PPP1CA	P62136	TP53BP2	Homo sapiens	Q05BL1	Validated Y2H	32296183
种属内	PPP1CA	P62136	TP53BP2	Homo sapiens	Q05BL1	Y2H Array	32296183
种属内	PPP1CA	P62136	TPRN	Homo sapiens	Q4KMQ1-2	Validated Y2H	32296183
种属内	PPP1CA	P62136	TPRN	Homo sapiens	Q4KMQ1-2	Anti Tag CoIP	28514442
种属内	PPP1CA	P62136	TPRN	Homo sapiens	Q4KMQ1-2	Y2H Array	32296183
种属内	PPP1CA	P62136	TPRN	Homo sapiens	Q4KMQ1-2	Y2H Prey Pooling	32296183
种属内	PPP1CA	P62136	PPP1R10	Homo sapiens	Q96QC0	BioID	28330616
种属内	PPP1CA	P62136	PPP1R10	Homo sapiens	Q96QC0	Pull Down	28330616
种属内	PPP1CA	P62136	PPP1R10	Homo sapiens	Q96QC0	Anti Tag CoIP	33961781
种属内	PPP1CA	P62136	PPP1R10	Homo sapiens	Q96QC0	Anti Tag CoIP	28514442
种属内	PPP1CA	P62136	PPP1R8	Homo sapiens	Q12972-2	Y2H Prey Pooling	32296183
种属内	PPP1CA	P62136	PPP1R8	Homo sapiens	Q12972-2	Validated Y2H	32296183
种属内	PPP1CA	P62136	PPP1R8	Homo sapiens	Q12972-2	Y2H Array	32296183
种属内	PPP1CA	P62136	PPP1R8	Homo sapiens	Q12972-2	Anti Tag CoIP	28514442
种属内	PPP1CA	P62136	PPP1R8	Homo sapiens	Q12972-1	ITC	22940584
种属内	PPP1CA	P62136	PPP1R8	Homo sapiens	Q12972-1	Ion Exchange Chrom	22940584
种属内	PPP1CA	P62136	PPP1R8	Homo sapiens	Q12972-1	X-Ray Diffraction	22940584
种属内	PPP1CA	P62136	PPP1R8	Homo sapiens	Q12972-1	Pull Down	22940584
种属内	PPP1CA	P62136	PPP1R8	Homo sapiens	Q12972-1	GMS	22940584
种属内	PPP1CA	P62136	PPP1R8	Homo sapiens	Q12972-1	NMR	22940584
种属内	PPP1CA	P62136	AATK	Homo sapiens	Q6ZMQ8	Ub Reconstruction	28065597
种属内	PPP1CA	P62136	CEP192	Homo sapiens	Q8TEP8	Pull Down	19389623
种属内	PPP1CA	P62136	CEP192	Homo sapiens	Q8TEP8	Far-WB	19389623
种属内	PPP1CA	P62136	PPP1R3C	Homo sapiens	Q9UQK1	Y2H Prey Pooling	32296183
种属内	PPP1CA	P62136	PPP1R3C	Homo sapiens	Q9UQK1	Validated Y2H	32296183
种属内	PPP1CA	P62136	PPP1R3C	Homo sapiens	Q9UQK1	Y2H	22321011
种属内	PPP1CA	P62136	PPP1R3C	Homo sapiens	Q9UQK1	Y2H Array	32296183
种属内	PPP1CA	P62136	PPP1R18	Homo sapiens	Q6NYC8	Anti Tag CoIP	33961781
种属内	PPP1CA	P62136	PPP1R18	Homo sapiens	Q6NYC8	Anti Tag CoIP	28514442
种属内	PPP1CA	P62136	PPP1R18	Homo sapiens	Q6NYC8	BioID	28330616
种属内	PPP1CA	P62136	PPP1R18	Homo sapiens	Q6NYC8	Pull Down	28330616
种属内	PPP1CA	P62136	PPP1R18	Homo sapiens	Q6NYC8	Anti Bait CoIP	25593058
种属内	PPP1CA	P62136	TRPC4AP	Homo sapiens	Q8TEL6	Pull Down	19389623
种属内	PPP1CA	P62136	TOR1AIP1	Homo sapiens	Q5JTV8	Anti Bait CoIP	24116158
种属内	PPP1CA	P62136	TOR1AIP1	Homo sapiens	Q5JTV8	Y2H	22321011
种属内	PPP1CA	P62136	SYTL2	Homo sapiens	Q9HCH5	Y2H	15231748
种属内	PPP1CA	P62136	PPP1R15B	Homo sapiens	Q5SWA1	Y2H	15231748
种属内	PPP1CA	P62136	PPP1R15B	Homo sapiens	Q5SWA1	Y2H	21382349
种属内	PPP1CA	P62136	PPP1R15B	Homo sapiens	Q5SWA1	BioID	28330616
种属内	PPP1CA	P62136	PPP1R15B	Homo sapiens	Q5SWA1	Pull Down	28330616
种属内	PPP1CA	P62136	ZFYVE9	Homo sapiens	O95405	Anti Tag CoIP	33961781
种属内	PPP1CA	P62136	ZFYVE9	Homo sapiens	O95405	Y2H	15231748
种属内	PPP1CA	P62136	ZFYVE16	Homo sapiens	Q7Z3T8	Anti Tag CoIP	28514442
种属内	PPP1CA	P62136	ZFYVE16	Homo sapiens	Q7Z3T8	Anti Tag CoIP	33961781
种属内	PPP1CA	P62136	SKP1	Homo sapiens	P63208	Anti Bait CoIP	17274640
种属内	PPP1CA	P62136	SKP1	Homo sapiens	P63208	Anti Bait CoIP	38057879
种属内	PPP1CA	P62136	PPP1R26	Homo sapiens	Q5T8A7	Pull Down	19389623
种属内	PPP1CA	P62136	PLCL2	Homo sapiens	Q9UPR0	Anti Tag CoIP	33961781
种属内	PPP1CA	P62136	PLCL2	Homo sapiens	Q9UPR0	Anti Tag CoIP	28514442
种属内	PPP1CA	P62136	BRCA1	Homo sapiens	P38398	Anti Tag CoIP	17511879
种属内	PPP1CA	P62136	BRCA1	Homo sapiens	P38398	Anti Bait CoIP	17511879
种属内	PPP1CA	P62136	PPP1R9B	Homo sapiens	Q96SB3	Y2H	22321011
种属内	PPP1CA	P62136	PPP1R9B	Homo sapiens	Q96SB3	Anti Tag CoIP	28514442
种属内	PPP1CA	P62136	PPP1R9B	Homo sapiens	Q96SB3	Anti Bait CoIP	25593058
种属内	PPP1CA	P62136	PPP1R9B	Homo sapiens	Q96SB3	Anti Bait CoIP	25785436
种属内	PPP1CA	P62136	PPP1R9B	Homo sapiens	Q96SB3	Pull Down	28330616
种属内	PPP1CA	P62136	PPP1R9B	Homo sapiens	Q96SB3	Y2H	15231748
种属内	PPP1CA	P62136	PPP1R9B	Homo sapiens	Q96SB3	Anti Tag CoIP	33961781
种属内	PPP1CA	P62136	VCP	Homo sapiens	P55072	Anti Bait CoIP	25593058
种属内	PPP1CA	P62136	KIF18A	Homo sapiens	Q8NI77	Y2H	15231748
种属内	PPP1CA	P62136	KIF18A	Homo sapiens	Q8NI77	Anti Tag CoIP	33961781
种属内	PPP1CA	P62136	KIF18A	Homo sapiens	Q8NI77	TAP	27173435
种属内	PPP1CA	P62136	KIF18A	Homo sapiens	Q8NI77	Anti Tag CoIP	28514442
种属内	PPP1CA	P62136	YBX3	Homo sapiens	P16989	IF	25593058
种属内	PPP1CA	P62136	YBX3	Homo sapiens	P16989	Anti Bait CoIP	25593058
种属内	PPP1CA	P62136	RRP1B	Homo sapiens	Q14684	Far-WB	20926688
种属内	PPP1CA	P62136	RRP1B	Homo sapiens	Q14684	Pull Down	19389623
种属内	PPP1CA	P62136	CDC5L	Homo sapiens	Q99459	Phosphatase Assay	22940584
种属内	PPP1CA	P62136	PPP1R3B	Homo sapiens	Q86XI6	Y2H Prey Pooling	32296183
种属内	PPP1CA	P62136	PPP1R3B	Homo sapiens	Q86XI6	Validated Y2H	32296183
种属内	PPP1CA	P62136	PPP1R3B	Homo sapiens	Q86XI6	Y2H Array	32296183
种属内	PPP1CA	P62136	TPRN	Homo sapiens	Q4KMQ1	Y2H	22321011
种属内	PPP1CA	P62136	TPRN	Homo sapiens	Q4KMQ1	Pull Down	28330616
种属内	PPP1CA	P62136	TPRN	Homo sapiens	Q4KMQ1	BioID	28330616
种属内	PPP1CA	P62136	TPRN	Homo sapiens	Q4KMQ1	Anti Tag CoIP	33961781
种属内	PPP1CA	P62136	TSC2	Homo sapiens	P49815	Far-WB	19389623
种属内	PPP1CA	P62136	TSC2	Homo sapiens	P49815	Pull Down	19389623
种属内	PPP1CA	P62136	CSRNP1	Homo sapiens	Q96S65	Y2H Prey Pooling	32296183
种属内	PPP1CA	P62136	CSRNP1	Homo sapiens	Q96S65	Validated Y2H	32296183
种属内	PPP1CA	P62136	CSRNP1	Homo sapiens	Q96S65	Y2H	22321011
种属内	PPP1CA	P62136	CSRNP1	Homo sapiens	Q96S65	Y2H Array	32296183
种属内	PPP1CA	P62136	CSRNP1	Homo sapiens	Q96S65	Anti Tag CoIP	33961781
种属内	PPP1CA	P62136	CSRNP1	Homo sapiens	Q96S65	Anti Tag CoIP	28514442
种属内	PPP1CA	P62136	CSRNP1	Homo sapiens	Q96S65	Y2H Prey Pooling	25416956
种属内	PPP1CA	P62136	SAXO4	Homo sapiens	Q7Z5V6	Far-WB	19389623
种属内	PPP1CA	P62136	ZFYVE1	Homo sapiens	Q9HBF4	Pull Down	19389623
种属内	PPP1CA	P62136	APAF1	Homo sapiens	O14727	Antibody Array	17274640
种属内	PPP1CA	P62136	APAF1	Homo sapiens	O14727	Anti Bait CoIP	17274640
种属内	PPP1CA	P62136	WNK1	Homo sapiens	Q9H4A3	Pull Down	19389623
种属内	PPP1CA	P62136	RB1	Homo sapiens	P06400	Antibody Array	17274640
种属内	PPP1CA	P62136	RB1	Homo sapiens	P06400	Pull Down	8384581
种属内	PPP1CA	P62136	SPRED1	Homo sapiens	Q7Z699	Far-WB	19389623
种属内	PPP1CA	P62136	TMEM132D	Homo sapiens	Q14C87	Pull Down	19389623
种属内	PPP1CA	P62136	PPP1R27	Homo sapiens	Q86WC6	Y2H Array	32296183
种属内	PPP1CA	P62136	PPP1R27	Homo sapiens	Q86WC6	Y2H Prey Pooling	32296183
种属内	PPP1CA	P62136	PPP1R27	Homo sapiens	Q86WC6	Far-WB	19389623
种属内	PPP1CA	P62136	PPP1R27	Homo sapiens	Q86WC6	Validated Y2H	32296183
种属内	PPP1CA	P62136	PPP1R27	Homo sapiens	Q86WC6	Pull Down	19389623
种属内	PPP1CA	P62136	PPP1R37	Homo sapiens	O75864	Anti Tag CoIP	33961781
种属内	PPP1CA	P62136	PPP1R37	Homo sapiens	O75864	Anti Tag CoIP	28514442
种属内	PPP1CA	P62136	PPP1R37	Homo sapiens	O75864	BioID	28330616
种属内	PPP1CA	P62136	PPP1R37	Homo sapiens	O75864	Pull Down	28330616
种属内	PPP1CA	P62136	PPP1R37	Homo sapiens	O75864	Pull Down	19389623
种属内	PPP1CA	P62136	MPHOSPH10	Homo sapiens	O00566	Y2H	15231748
种属内	PPP1CA	P62136	MPHOSPH10	Homo sapiens	O00566	Pull Down	19389623
种属内	PPP1CA	P62136	CSRNP2	Homo sapiens	Q9H175	Pull Down	19389623
种属内	PPP1CA	P62136	CSRNP2	Homo sapiens	Q9H175	Y2H Prey Pooling	32296183
种属内	PPP1CA	P62136	CSRNP2	Homo sapiens	Q9H175	Validated Y2H	32296183
种属内	PPP1CA	P62136	CSRNP2	Homo sapiens	Q9H175	Y2H Array	25416956
种属内	PPP1CA	P62136	CSRNP2	Homo sapiens	Q9H175	Y2H Array	32296183
种属内	PPP1CA	P62136	CSRNP2	Homo sapiens	Q9H175	Anti Tag CoIP	33961781
种属内	PPP1CA	P62136	CSRNP2	Homo sapiens	Q9H175	Anti Tag CoIP	28514442
种属内	PPP1CA	P62136	LRRK2	Homo sapiens	Q5S007	PPase Assay	23937259
种属内	PPP1CA	P62136	LRRK2	Homo sapiens	Q5S007	PLA	23937259
种属内	PPP1CA	P62136	LRRK2	Homo sapiens	Q5S007	Anti Tag CoIP	23937259
种属内	PPP1CA	P62136	PPP1R13L	Homo sapiens	Q8WUF5	Anti Tag CoIP	33961781
种属内	PPP1CA	P62136	PPP1R13L	Homo sapiens	Q8WUF5	TAP	27173435
种属内	PPP1CA	P62136	PPP1R13L	Homo sapiens	Q8WUF5	Anti Tag CoIP	28514442
种属内	PPP1CA	P62136	PPP1R13L	Homo sapiens	Q8WUF5	Y2H	22321011
种属内	PPP1CA	P62136	PPP1R13L	Homo sapiens	Q8WUF5	Anti Tag CoIP	21998301
种属内	PPP1CA	P62136	PPP1R13L	Homo sapiens	Q8WUF5	BioID	28330616
种属内	PPP1CA	P62136	PPP1R13L	Homo sapiens	Q8WUF5	Pull Down	28330616
种属内	PPP1CA	P62136	PTEN	Homo sapiens	P60484	Antibody Array	17274640
种属内	PPP1CA	P62136	AXIN1	Homo sapiens	O15169	Anti Bait CoIP	17318175
种属内	PPP1CA	P62136	AXIN1	Homo sapiens	O15169	Anti Tag CoIP	17318175
种属内	PPP1CA	P62136	RIF1	Homo sapiens	Q5UIP0	BioID	28330616
种属内	PPP1CA	P62136	RIF1	Homo sapiens	Q5UIP0	Pull Down	28330616
种属内	PPP1CA	P62136	RIF1	Homo sapiens	Q5UIP0	Anti Tag CoIP	33961781
种属内	PPP1CA	P62136	RIF1	Homo sapiens	Q5UIP0	TAP	27173435
种属内	PPP1CA	P62136	YLPM1	Homo sapiens	P49750	Anti Tag CoIP	33961781
种属内	PPP1CA	P62136	YLPM1	Homo sapiens	P49750	Y2H	22321011
种属内	PPP1CA	P62136	YLPM1	Homo sapiens	P49750	BioID	28330616
种属内	PPP1CA	P62136	YLPM1	Homo sapiens	P49750	Pull Down	28330616
种属内	PPP1CA	P62136	WBP11	Homo sapiens	Q9Y2W2	Anti Tag CoIP	33961781
种属内	PPP1CA	P62136	WBP11	Homo sapiens	Q9Y2W2	TAP	27173435
种属内	PPP1CA	P62136	WBP11	Homo sapiens	Q9Y2W2	Anti Tag CoIP	28514442
种属内	PPP1CA	P62136	PPP1R15A	Homo sapiens	O75807	BiFC	26095357
种属内	PPP1CA	P62136	PPP1R15A	Homo sapiens	O75807	Pull Down	26095357
种属内	PPP1CA	P62136	PPP1R15A	Homo sapiens	O75807	ITC	26095357
种属内	PPP1CA	P62136	PPP1R15A	Homo sapiens	O75807	X-Ray Diffraction	26095357
种属内	PPP1CA	P62136	PPP1R8	Homo sapiens	Q12972	BioID	28330616
种属内	PPP1CA	P62136	PPP1R8	Homo sapiens	Q12972	Pull Down	28330616
种属内	PPP1CA	P62136	PPP1R8	Homo sapiens	Q12972	Anti Tag CoIP	33961781
种属内	PPP1CA	P62136	PPP1R8	Homo sapiens	Q12972	TAP	27173435
种属内	PPP1CA	P62136	PPP1R8	Homo sapiens	Q12972	Y2H	15231748
种属内	PPP1CA	P62136	PPP1R8	Homo sapiens	Q12972	Anti Bait CoIP	25593058
种属内	PPP1CA	P62136	SH2D4A	Homo sapiens	Q9H788	Pull Down	19389623
种属内	PPP1CA	P62136	CNST	Homo sapiens	Q6PJW8	Anti Tag CoIP	28514442
种属内	PPP1CA	P62136	CNST	Homo sapiens	Q6PJW8	Anti Tag CoIP	33961781
种属内	PPP1CA	P62136	CNST	Homo sapiens	Q6PJW8	Pull Down	19389623
种属内	PPP1CA	P62136	TP53BP2	Homo sapiens	Q13625	BioID	28330616
种属内	PPP1CA	P62136	TP53BP2	Homo sapiens	Q13625	Anti Tag CoIP	33961781
种属内	PPP1CA	P62136	TP53BP2	Homo sapiens	Q13625	Anti Tag CoIP	21998301
种属内	PPP1CA	P62136	TP53BP2	Homo sapiens	Q13625	Pull Down	28330616
种属间	PPP1CA	P62136	Clock	Mus musculus	O08785	Y2H	23555304
种属内	PPP1CA	P62136	DLG3	Homo sapiens	Q92796	Far-WB	19389623
种属内	PPP1CA	P62136	FOXP3	Homo sapiens	Q9BZS1	Anti Bait CoIP	23396208
种属内	PPP1CA	P62136	SGO2	Homo sapiens	Q562F6	Anti Tag CoIP	21666598
种属间	PPP1CA	P62136	N	Middle East respiratory syndrome-related coronavirus	K9N4V7	P8 Filamentous Phage	34799561
种属间	PPP1CA	P62136	N	Middle East respiratory syndrome-related coronavirus	K9N4V7	Phage Display	37100772
种属间	PPP1CA	P62136	ICP34.5	Human herpesvirus 1	P36313	BiFC	18068675
种属间	PPP1CA	P62136	Ppp1r9a	Rattus norvegicus	O35867	X-Ray Diffraction	20305656
种属间	PPP1CA	P62136	Ppp1r9a	Rattus norvegicus	O35867	GMS	20305656
种属间	PPP1CA	P62136	Ppp1r9a	Rattus norvegicus	O35867	Pull Down	20305656
种属间	PPP1CA	P62136	Ppp1r9b	Rattus norvegicus	O35274	X-Ray Diffraction	20305656
种属间	PPP1CA	P62136	Ppp1r9b	Rattus norvegicus	O35274	Anti Tag CoIP	25785436
种属间	PPP1CA	P62136	Ppp1r9b	Rattus norvegicus	O35274	GMS	20305656
种属间	PPP1CA	P62136	Ppp1r9b	Rattus norvegicus	O35274	Pull Down	20305656
种属间	PPP1CA	P62136	Ppp1r9b	Rattus norvegicus	O35274	SAXS	21094159
种属间	PPP1CA	P62136	Ppp1r9b	Rattus norvegicus	O35274	ITC	20305656

种属间: 跨种属相互作用 种属内: 同种属相互作用

PPP1CA 抗体

目录号	产品名	应用	反应物种
HY-P81305	PP1C alpha Antibody (YA1040)	WB, IHC-F, IHC-P, ICC/IF	Human
HY-P81305A	PP1C alpha Antibody (YA1041)	WB, ICC/IF	Human
HY-P81955	PP1C alpha/beta Antibody (YA1700)	WB, IHC-P, IP	Human, Mouse, Rat

关联疾病

疾病名称

别名

Venezuelan Equine Encephalitis

Venezuelan Equine Fever	Venezuelan Equine Encephalomyelitis
Encephalitis Venezuelan Equine	Encephalomyelitis, Venezuelan Equine
Venezuelan Encephalitis	Disorder Due To Venezuelan Equine Encephalitis Virus
Venezuelan Equine Encephalitis Virus Infection	Venezuelan Equine Encephalomyelitis Virus Disease

Encephalitis

Mumps Encephalitis	Mumps Meningoencephalitis
Herpes Simplex Neuroinvasion	Herpetic Encephalitis
Herpetic Encephalopathy	Herpes Simplex Encephalitis, Myelitis Or Encephalomyelitis
Encephalitis Due To Herpesviridae	Encephalitis Due To Herpesvirus
Herpes Encephalitis	Herpesviral Encephalitis
Herpes Simplex Encephalitis	Hsv - [Herpes Simplex Virus] Encephalitis
Herpes Virus Encephalitis	Simian B Disease
Simian B Disorder	Encephalitis Nec
Idiopathic Encephalitis

Rheumatoid Arthritis

RA	Arthritis, Rheumatoid
Rheumatoid Arthritis, Susceptibility To	Arthritis Or Polyarthritis, Rheumatic
Atrophic Arthritis	Rheumatism Arthritis
Rheumatoid Polyarthritis

Middle East Respiratory Syndrome

Mers	Mers - [Middle East Respiratory Syndrome]

Ebola Hemorrhagic Fever

Ebola Virus Disease	Viral Hemorrhagic Fever
Hemorrhagic Fever, Ebola	Ebola
Ehf	Ebola Fever
Hemorrhagic Fevers, Viral	Ebola Haemorrhagic Fever
Ebod - [Ebola Disease]	Evd - [Ebola Virus Disease]
Ebola Virus Haemorrhagic Fever	Vhf - [Viral Haemorrhagic Fever] Nos
Viral Haemorrhagic Fever, Not Otherwise Specified

Croup

Acute Obstructive Laryngitis	Laryngotracheobronchitis
Acute Laryngotracheobronchitis	Croup Syndrome
Acute Laryngitis With Obstruction	Obstructive Laryngitis
Obstructive Laryngitis Nos	Obstructive Laryngotracheitis Nos

Coronavirus Infectious Disease

Common Cold

Acute Coryza	Acute Nasopharyngitis
Acute Rhinitis	Acute Viral Rhinopharyngitis
Nasopharyngitis - Acute	Nasopharyngitis, Acute
Rhino-Sinusitis	Rhinosinusitis
Common Colds	Acute Infective Rhinitis
Cold	Coryza
Head Cold	Infective Nasopharyngitis
Rhinopharyngitis	Acute Nasal Catarrh
Infective Rhinitis	Acute Nasopharyngeal Catarrh
Infective Nasopharyngitis Nos	Nasopharyngitis Nos
Epipharyngitis	Mucositis Nos
Inflammatory Disease Of Mucous Membrane	Mucosal Inflammation

Viral Pneumonia

Pneumonia, Viral	Acute Viral Pneumonia
Bronchopneumonia Due To Viruses Other Than Influenza Viruses	Interstitial Viral Pneumonia
Viral Bronchopneumonia	Viral Double Pneumonia
Viral Lobar Pneumonia	Viral Purulent Pneumonia
Virus Interstitial Pneumonia	Virus Lobar Pneumonia

Acute Diarrhea

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS10973	PPP1CA Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	PPP1CA	VGNC	VGNC:106874
Felis catus	PPP1CA	VGNC	VGNC:105823
Rattus norvegicus	PPP1CA	RGD	RGD:3375
Mus musculus	PPP1CA	MGD	MGI:103016
Macaca mulatta	PPP1CA	VGNC	VGNC:76366

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