PPP1CA - protein phosphatase 1 catalytic subunit alpha Gene

中文名称：蛋白磷酸酶 1 催化亚基 α

种属: Homo sapiens

同用名: PP1A; PP-1A; PPP1A; PP1alpha

基因 ID: 5499 | 基因类型: protein coding

关于 PPP1CA

Cytogenetic location: 11q13.2 Genomic coordinates (GRCh38): 11:67,398,183-67,401,858 (from NCBI)

This gene has 14 transcripts (splice variants), 177 orthologues and 12 paralogues. Ubiquitous expression in lymph node (RPKM 67.2), colon (RPKM 56.9) and 25 other tissues.

功能概要

该基因编码的蛋白质是蛋白磷酸酶 1 (PP1) 的三个催化亚基之一。这种广泛表达的基因编码 PP1 复合体的 α 亚基，该复合体与 200 多种调节蛋白结合形成全酶，以高特异性去磷酸化其生物靶标。 PP1 是一种丝氨酸/苏氨酸特异性蛋白磷酸酶，已知参与多种细胞过程的调节，例如细胞分裂、糖原代谢、肌肉收缩性、蛋白质合成和 HIV-1 病毒转录。在心力衰竭末期观察到 PP1 活性增加。研究表明，PP1 是心脏功能的重要调节因子，PP1 失调与糖尿病和多种癌症有关。已经为该基因发现了编码不同同种型的三种选择性剪接的转录物变体。[RefSeq 提供，2020 年 7 月]

The protein encoded by this gene is one of the three catalytic subunits of protein Phosphatase 1 (PP1). This broadly expressed gene encodes the alpha subunit of the PP1 complex that associates with over 200 regulatory proteins to form holoenzymes which dephosphorylate their biological targets with high specificity. PP1 is a serine/threonine specific protein Phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies suggest that PP1 is an important regulator of cardiac function and that PP1 deregulation is implicated in diabetes and multiple types of Cancer. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2020]

PPP1CA 基因产物(3)

mRNA	Protein	Name
NM_001008709.2	NP_001008709.1	serine/threonine-protein phosphatase PP1-alpha catalytic subunit isoform 3
NM_002708.4	NP_002699.1	serine/threonine-protein phosphatase PP1-alpha catalytic subunit isoform 1
NM_206873.2	NP_996756.1	serine/threonine-protein phosphatase PP1-alpha catalytic subunit isoform 2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables cadherin binding involved in cell-cell adhesion	IDA IDA: 通过直接分析推断	25468996	GOA
enables iron ion binding	IDA IDA: 通过直接分析推断	30403291	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	10807923	GOA
enables protein serine/threonine phosphatase activity	IDA IDA: 通过直接分析推断	28216226	GOA
enables transition metal ion binding	IDA IDA: 通过直接分析推断	30403291	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in dephosphorylation	IDA IDA: 通过直接分析推断	22311981	GOA
acts upstream of or within protein dephosphorylation	IMP IMP: 通过突变表型推断	22801782	GOA
involved in protein dephosphorylation	IMP IMP: 通过突变表型推断	22311981	GOA
involved in regulation of circadian rhythm	IMP IMP: 通过突变表型推断	21712997	GOA
involved in telomere maintenance in response to DNA damage	IDA IDA: 通过直接分析推断	28216226	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of PTW/PP1 phosphatase complex	IDA IDA: 通过直接分析推断	20516061	GOA
located in adherens junction	IDA IDA: 通过直接分析推断	25468996	GOA
colocalizes with chromosome, telomeric region	IDA IDA: 通过直接分析推断	24270157	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	11739654	GOA
located in nucleus	IDA IDA: 通过直接分析推断	11739654	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PPP1CA 蛋白结构

Metallophos

0
100
200
300
330 a.a.

蛋白主名

其他名称

serine/threonine-protein phosphatase PP1-alpha catalytic subunit

protein phosphatase 1, catalytic subunit, alpha isozyme

关联疾病

疾病名称

别名

Venezuelan Equine Encephalitis

Venezuelan Equine Fever	Venezuelan Equine Encephalomyelitis
Encephalitis Venezuelan Equine	Encephalomyelitis, Venezuelan Equine
Venezuelan Encephalitis	Disorder Due To Venezuelan Equine Encephalitis Virus
Venezuelan Equine Encephalitis Virus Infection	Venezuelan Equine Encephalomyelitis Virus Disease

Encephalitis

Mumps Encephalitis	Mumps Meningoencephalitis
Herpes Simplex Neuroinvasion	Herpetic Encephalitis
Herpetic Encephalopathy	Herpes Simplex Encephalitis, Myelitis Or Encephalomyelitis
Encephalitis Due To Herpesviridae	Encephalitis Due To Herpesvirus
Herpes Encephalitis	Herpesviral Encephalitis
Herpes Simplex Encephalitis	Hsv - [Herpes Simplex Virus] Encephalitis
Herpes Virus Encephalitis	Simian B Disease
Simian B Disorder	Encephalitis Nec
Idiopathic Encephalitis

Rheumatoid Arthritis

RA	Arthritis, Rheumatoid
Rheumatoid Arthritis, Susceptibility To	Arthritis Or Polyarthritis, Rheumatic
Atrophic Arthritis	Rheumatism Arthritis
Rheumatoid Polyarthritis

Middle East Respiratory Syndrome

Mers	Mers - [Middle East Respiratory Syndrome]

Ebola Hemorrhagic Fever

Ebola Virus Disease	Viral Hemorrhagic Fever
Hemorrhagic Fever, Ebola	Ebola
Ehf	Ebola Fever
Hemorrhagic Fevers, Viral	Ebola Haemorrhagic Fever
Ebod - [Ebola Disease]	Evd - [Ebola Virus Disease]
Ebola Virus Haemorrhagic Fever	Vhf - [Viral Haemorrhagic Fever] Nos
Viral Haemorrhagic Fever, Not Otherwise Specified

Croup

Acute Obstructive Laryngitis	Laryngotracheobronchitis
Acute Laryngotracheobronchitis	Croup Syndrome
Acute Laryngitis With Obstruction	Obstructive Laryngitis
Obstructive Laryngitis Nos	Obstructive Laryngotracheitis Nos

Coronavirus Infectious Disease

Common Cold

Acute Coryza	Acute Nasopharyngitis
Acute Rhinitis	Acute Viral Rhinopharyngitis
Nasopharyngitis - Acute	Nasopharyngitis, Acute
Rhino-Sinusitis	Rhinosinusitis
Common Colds	Acute Infective Rhinitis
Cold	Coryza
Head Cold	Infective Nasopharyngitis
Rhinopharyngitis	Acute Nasal Catarrh
Infective Rhinitis	Acute Nasopharyngeal Catarrh
Infective Nasopharyngitis Nos	Nasopharyngitis Nos
Epipharyngitis	Mucositis Nos
Inflammatory Disease Of Mucous Membrane	Mucosal Inflammation

Viral Pneumonia

Pneumonia, Viral	Acute Viral Pneumonia
Bronchopneumonia Due To Viruses Other Than Influenza Viruses	Interstitial Viral Pneumonia
Viral Bronchopneumonia	Viral Double Pneumonia
Viral Lobar Pneumonia	Viral Purulent Pneumonia
Virus Interstitial Pneumonia	Virus Lobar Pneumonia

Acute Diarrhea

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS10973	PPP1CA Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	PPP1CA	VGNC	VGNC:106874
Felis catus	PPP1CA	VGNC	VGNC:105823
Rattus norvegicus	PPP1CA	RGD	RGD:3375
Mus musculus	PPP1CA	MGD	MGI:103016
Macaca mulatta	PPP1CA	VGNC	VGNC:76366

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

PPP1CA - protein phosphatase 1 catalytic subunit alpha Gene

关于 PPP1CA

功能概要

PPP1CA 基因产物(3)

PPP1CA 蛋白结构

关联疾病

直系同源

热门区域

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PPP1CA - protein phosphatase 1 catalytic subunit alpha Gene

关于 PPP1CA

功能概要

PPP1CA 基因产物(3)

PPP1CA 蛋白结构

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z