2. Gene
  3. PPP1R15A - protein phosphatase 1 regulatory subunit 15A Gene

PPP1R15A - protein phosphatase 1 regulatory subunit 15A Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：蛋白磷酸酶 1 调节亚基 15A

种属: Homo sapiens

同用名: GADD34

基因 ID: 23645 | 基因类型: protein coding

关于 PPP1R15A

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:48,872,421-48,876,058 (from NCBI)

This gene has 5 transcripts (splice variants), 112 orthologues and 1 paralogue. Broad expression in bone marrow (RPKM 214.4), gall bladder (RPKM 51.1) and 23 other tissues.

功能概要

该基因是一组基因的成员，其转录水平在应激生长停滞条件和 DNA 损伤剂处理后增加。无论 p53 状态如何，某些细胞系都会通过电离辐射诱导该基因，并且其蛋白质反应与电离辐射后的细胞凋亡相关。[RefSeq 提供，2008 年 7 月]

This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The induction of this gene by ionizing radiation occurs in certain cell lines regardless of p53 status, and its protein response is correlated with Apoptosis following ionizing radiation. [provided by RefSeq, Jul 2008]

PPP1R15A 基因产物(1)

mRNA Protein Name
NM_014330.5 NP_055145.3 protein phosphatase 1 regulatory subunit 15A
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
11564868 GOA
enables protein kinase binding IPI
IPI: 通过物理相互作用推断
11517336 GOA
enables protein phosphatase 1 binding IDA
IDA: 通过直接分析推断
11564868 GOA
enables protein phosphatase 1 binding IPI
IPI: 通过物理相互作用推断
12556489 GOA
enables protein phosphatase regulator activity IDA
IDA: 通过直接分析推断
12556489 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in protein localization to endoplasmic reticulum IMP
IMP: 通过突变表型推断
12556489 GOA
involved in regulation of translational initiation IDA
IDA: 通过直接分析推断
11564868 GOA
involved in regulation of translational initiation in response to stress IDA
IDA: 通过直接分析推断
11564868 GOA
involved in response to endoplasmic reticulum stress IDA
IDA: 通过直接分析推断
12556489 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Golgi apparatus IDA
IDA: 通过直接分析推断
21518769 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
21518769 GOA
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
12556489 GOA
located in membrane IDA
IDA: 通过直接分析推断
21518769 GOA
located in mitochondrion IDA
IDA: 通过直接分析推断
21518769 GOA
part of protein phosphatase type 1 complex IDA
IDA: 通过直接分析推断
11564868 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PPP1R15A 蛋白结构

PP1c_bdg

PP1c_bdg: Phosphatase-1 catalytic subunit binding region (544 - 619)

  • 0
  • 200
  • 400
  • 600
  • 674 a.a.
蛋白主名 其他名称

protein phosphatase 1 regulatory subunit 15A

growth arrest and DNA damage-inducible protein GADD34

关联疾病

疾病名称 别名
Epiphyseal Dysplasia, Multiple, With Early-Onset Diabetes Mellitus

Wolcott-Rallison Syndrome

Med-Iddm Syndrome

Iddm-Med Syndrome

Wolcott Rallison Syndrome

WRS

Epiphyseal Dysplasia Multiple With Early-Onset Diabetes Mellitus

Early-Onset Diabetes Mellitus With Multiple Epiphyseal Dysplasia

Multiple Epiphyseal Dysplasia With Early-Onset Diabetes Mellitus
Charcot-Marie-Tooth Disease, Demyelinating, Type 1b

Charcot-Marie-Tooth Disease Type 1b

CMT1B

Hereditary Motor And Sensory Neuropathy Ib

Hmsn Ib

Hmsn1b

Peroneal Muscular Atrophy

Charcot-Marie-Tooth Disease, Type 1b

Charcot-Marie-Tooth Disease Slow Nerve Conduction Type Linked To Duffy

Charcot-Marie-Tooth Neuropathy Type 1b

Charcot-Marie-Tooth Disease, Type Ib

Hereditary Motor And Sensory Neuropathy I

Hmsn I

Hmsn1

Charcot-Marie-Tooth Neuropathy, Type 1b

Charcot-Marie-Tooth Disease, Slow Nerve Conduction Type, Linked To Duffy

Charcot-Marie-Tooth Disease, Autosomal Dominant, With Focally Folded Myelin Sheaths, Type 1b

Autosomal Dominant Charcot-Marie-Tooth Disease With Focally Folded Myelin Sheaths Type 1b

Charcot-Marie-Tooth Disease 1b

Charcot-Marie-Tooth Disease Demyelinating Type 1b

Hmsn Type I

Hereditary Motor And Sensory Neuropathy Type I

Charcot-Marie-Tooth Disease
Leukoencephalopathy With Vanishing White Matter

Cree Leukoencephalopathy

Vanishing White Matter Disease

Ovarioleukodystrophy

Vanishing White Matter Leukodystrophy

Childhood Ataxia With Central Nervous System Hypomyelinization

Cach

Cach Syndrome

Myelinosis Centralis Diffusa

VWM

Cle

Childhood Ataxia With Central Nervous System Hypomyelination

Childhood Ataxia With Diffuse Central Nervous System Hypomyelination

Cach/Vwm

Cach/Vwm Syndrome

Childhood Ataxia With Central Nervous System Hypomyelination/Vanishing White Matter

Cree Leukoencehalopathy

Late Infantile Cach Syndrome

Juvenile Or Adult Cach Syndrome

Congenital Or Early Infantile Cach Syndrome

Leukodystrophy With Vanishing White Matter
Melanoma

Malignant Melanoma

Cutaneous Melanoma

Naevocarcinoma

Malignant Melanomas
Charcot-Marie-Tooth Disease

Cmt

Hmsn

Hereditary Motor And Sensory Neuropathy

Pma

Cmt - Charcot-Marie-Tooth Disease

Charcot Marie Tooth Disease

Charcot-Marie-Tooth Hereditary Neuropathy

Charcot-Marie-Tooth Syndrome

Peroneal Muscular Atrophy

Hereditary Motor And Sensory Neuropathies
Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis

ALS

Lou Gehrig Disease

Amyotrophic Lateral Sclerosis Type 1

Charcot Disease

ALS1

Amyotrophic Lateral Sclerosis, Susceptibility To

Fals

Lou Gehrig'S Disease

Mnd

Motor Neuron Disease

Familial Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis 1, Familial

Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

Motor Neuron Disease, Bulbar

Motor Neurone Disease

Amyotrophic Lateral Sclerosis With Dementia

Dementia With Amyotrophic Lateral Sclerosis

Motor Neuron Disease, Amyotrophic Lateral Sclerosis

Sclerosis, Lateral, Amyotrophic

Sclerosis, Lateral, Amyotrophic, Type 1

Amyotrophic Sclerosis

Als - [Amyotrophic Lateral Sclerosis]

Wasting Palsy

Amyotrophic Paralysis

Amyotrophy Lateral Sclerosis

Wasting Paralysis

Spinal Progressive Amyotrophy

Progressive Atrophic Paralysis
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-111022 Icerguastat Inhibitor 99.90% Phase 2
Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-18956 (E/Z)-Icerguastat Inhibitor 99.44% 否
HY-110365 Icerguastat Carbonate Inhibitor / 否
HY-18956B (E/Z)-Icerguastat acetate Inhibitor / 否
HY-RS10986 PPP1R15A Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-18956A (E/Z)-Icerguastat hydrochloride Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris PPP1R15A VGNC VGNC:53754
Mus musculus PPP1R15A MGD MGI:1927072
Bos taurus PPP1R15A VGNC VGNC:33228
Rattus norvegicus PPP1R15A RGD RGD:621526
Macaca mulatta PPP1R15A VGNC VGNC:76254
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