1. Gene
  2. PPP1R1A - protein phosphatase 1 regulatory inhibitor subunit 1A Gene

PPP1R1A - protein phosphatase 1 regulatory inhibitor subunit 1A Gene

中文名称:蛋白磷酸酶 1 调节抑制因子亚基 1A

种属: Homo sapiens

同用名: I1; IPP1

基因 ID: 5502 | 基因类型: protein coding

关于 PPP1R1A

Cytogenetic location: 12q13.2 Genomic coordinates (GRCh38): 12:54,579,246-54,588,659 (from NCBI)

This gene has 4 transcripts (splice variants), 181 orthologues and 2 paralogues. Biased expression in fat (RPKM 174.0), kidney (RPKM 33.7) and 3 other tissues.

功能概要

预测可启用蛋白质丝氨酸/苏氨酸磷酸酶抑制剂活性。预计参与细胞内信号转导。预计在细胞质中有活性。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to enable protein serine/threonine Phosphatase Inhibitor activity. Predicted to be involved in intracellular signal transduction. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

PPP1R1A 基因产物(1)

mRNA Protein Name
NM_006741.4 NP_006732.3 protein phosphatase 1 regulatory subunit 1A
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
11564868 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

PPP1R1A 蛋白结构

DARPP-32

DARPP-32: Protein phosphatase inhibitor 1/DARPP-32 (1 - 151)

  • 0
  • 100
  • 171 a.a.
蛋白主名 其他名称

protein phosphatase 1 regulatory subunit 1A

I-1

PPP1R1A 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PPP1R1A Q13522 PPP1R15A Homo sapiens O75807
Y2H
11564868
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 PPP1R1A 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70987 PPP1R1A Protein, Human (His) AAH22470.1 (M1-V171) ≥95%

关联疾病

疾病名称 别名
Simple Partial Epilepsy

Epilepsy, Simple Partial

Dilated Cardiomyopathy

Familial Dilated Cardiomyopathy

Primary Dilated Cardiomyopathy

Idiopathic Dilated Cardiomyopathy

Congestive Cardiomyopathy

Idiopathic Dilation Cardiomyopathy

Primary Familial Dilated Cardiomyopathy

Cardiomyopathy, Dilated

DCM

Cardiomyopathy, Familial Dilated

Dilated Cardiomyopathy, Familial

Hypokinetic Dilated Cardiomyopathy, Familial

Familial Idiopathic Cardiomyopathy

Fdc

Cardiomyopathy, Familial Idiopathic

Idiopathic Cardiomegaly

Dilated Congestive Cardiomyopathy

Chronic Dilated Cardiomyopathy

Ccm - [Congestive Cardiomyopathy]

Cocm - [Congestive Cardiomyopathy]

Dcm - [Dilated Cardiomyopathy]

Dilated-Hypokinetic Cardiomyopathy

Congestive Idiopathic Cardiomyopathy

Primary Idiopathic Dilated Cardiomyopathy

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Canis familiaris PPP1R1A VGNC VGNC:58287
Mus musculus PPP1R1A MGD MGI:1889595
Macaca mulatta PPP1R1A VGNC VGNC:76368
Felis catus PPP1R1A VGNC VGNC:69000
Bos taurus PPP1R1A VGNC VGNC:54472
Rattus norvegicus PPP1R1A RGD RGD:62018
Others PPP1R1A NCBI