2. Gene
  3. ZFYVE1 - zinc finger FYVE-type containing 1 Gene

ZFYVE1 - zinc finger FYVE-type containing 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：含锌指 FYVE 型 1

种属: Homo sapiens

同用名: SR3; DFCP1; TAFF1; ZNFN2A1; PPP1R172

基因 ID: 53349 | 基因类型: protein coding

关于 ZFYVE1

Cytogenetic location: 14q24.2 Genomic coordinates (GRCh38): 14:72,969,445-73,027,106 (from NCBI)

This gene has 9 transcripts (splice variants), 263 orthologues and 13 paralogues. Ubiquitous expression in thyroid (RPKM 7.4), kidney (RPKM 6.4) and 25 other tissues.

功能概要

FYVE 结构域介导参与膜运输和细胞信号转导至含磷脂酰肌醇 3-磷酸的膜的蛋白质募集。该蛋白质包含两个串联的锌结合 FYVE 结构域，据报道定位于高尔基体。可变剪接导致多个转录本变体。[RefSeq 提供，2013 年 8 月]

The FYVE domain mediates the recruitment of proteins involved in membrane trafficking and cell signaling to phosphatidylinositol 3-phosphate-containing membranes. This protein contains two zinc-binding FYVE domains in tandem and is reported to localize to the Golgi apparatus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

ZFYVE1 基因产物(4)

mRNA Protein Name
NM_001281734.2 NP_001268663.1 zinc finger FYVE domain-containing protein 1 isoform 3
NM_001281735.1 NP_001268664.1 zinc finger FYVE domain-containing protein 1 isoform 2
NM_021260.4 NP_067083.1 zinc finger FYVE domain-containing protein 1 isoform 1
NM_178441.2 NP_848535.1 zinc finger FYVE domain-containing protein 1 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables 1-phosphatidylinositol binding IDA
IDA: 通过直接分析推断
11256955 GOA
enables phosphatidylinositol-3,4,5-trisphosphate binding IDA
IDA: 通过直接分析推断
11804589 GOA
enables phosphatidylinositol-3,4-bisphosphate binding IDA
IDA: 通过直接分析推断
11804589 GOA
enables phosphatidylinositol-3-phosphate binding IDA
IDA: 通过直接分析推断
31293035 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
19389623 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to starvation IDA
IDA: 通过直接分析推断
25578879 GOA
involved in lipid droplet formation IMP
IMP: 通过突变表型推断
30970241 GOA
involved in macroautophagy IDA
IDA: 通过直接分析推断
25578879 GOA
involved in positive regulation by host of viral genome replication IDA
IDA: 通过直接分析推断
35551511 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Golgi apparatus IDA
IDA: 通过直接分析推断
25876663 GOA
located in Golgi stack IDA
IDA: 通过直接分析推断
11256955 GOA
located in autophagosome IDA
IDA: 通过直接分析推断
22456507 GOA
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
11739631 GOA
located in endoplasmic reticulum membrane IDA
IDA: 通过直接分析推断
30970241 GOA
located in extrinsic component of omegasome membrane IDA
IDA: 通过直接分析推断
19898463 GOA
located in lipid droplet IDA
IDA: 通过直接分析推断
30970241 GOA
colocalizes with membrane IDA
IDA: 通过直接分析推断
25578879 GOA
located in mitochondria-associated endoplasmic reticulum membrane contact site IDA
IDA: 通过直接分析推断
23455425 GOA
located in mitochondrion IDA
IDA: 通过直接分析推断
25876663 GOA
located in omegasome IDA
IDA: 通过直接分析推断
24954904 GOA
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
11739631 GOA
located in phagophore assembly site IDA
IDA: 通过直接分析推断
23455425 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ZFYVE1 蛋白结构

FYVE

FYVE: FYVE zinc finger (594 - 657)

FYVE

FYVE: FYVE zinc finger (711 - 773)

  • 0
  • 200
  • 400
  • 600
  • 777 a.a.
蛋白主名 其他名称

zinc finger FYVE domain-containing protein 1

double FYVE-containing protein 1

ZFYVE1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
ZFYVE1 Q9HBF4 PPP1CA Homo sapiens P62136
Far-WB
19389623
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Argyll Robertson Pupil

Atypical Argyll-Robertson Pupil

Argyll Robertson Phenomenon Or Pupil, Nonsyphilitic

Argyll Robertson Pupil, Atypical
Abnormal Pupillary Function
Pupil Disease

Pupil Disorders

Pupillary Disorder
Diamond-Blackfan Anemia 5

DBA5

Rpl35a-Related Diamond-Blackfan Anemia

Anemia, Diamond-Blackfan, Type 5
Retinitis Pigmentosa 7

Leber Congenital Amaurosis 18

RP7

Retinitis Pigmentosa 7, Digenic Form

Retinitis Pigmentosa 7 And Digenic Form

Retinitis Pigmentosa 7, Digenic

LCA18

Retinitis Pigmentosa 7 Digenic
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS16055 ZFYVE1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta ZFYVE1 VGNC VGNC:78911
Mus musculus ZFYVE1 MGD MGI:3026685
Bos taurus ZFYVE1 VGNC VGNC:37173
Rattus norvegicus ZFYVE1 RGD RGD:1307795
Canis familiaris ZFYVE1 VGNC VGNC:48622
Felis catus ZFYVE1 VGNC VGNC:67237
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z