AATK - apoptosis associated tyrosine kinase Gene

中文名称：凋亡相关酪氨酸激酶

种属: Homo sapiens

同用名: LMR1; AATYK; LMTK1; p35BP; AATYK1; PPP1R77

关于 AATK

功能概要

该基因编码的蛋白质在 N 端包含一个酪氨酸激酶结构域，在 C 端包含一个富含脯氨酸的结构域。该基因在细胞凋亡过程中被诱导，并且该基因的表达可能是诱导骨髓前体细胞生长停滞和/或细胞凋亡的必要先决条件。该基因已被证明可在成神经细胞瘤细胞系中产生神经元分化。已发现该基因的两个转录本变体编码不同的亚型。[RefSeq 提供，2011 年 6 月]

The protein encoded by this gene contains a tyrosine kinase domain at the N-terminus and a proline-rich domain at the C-terminus. This gene is induced during Apoptosis, and expression of this gene may be a necessary pre-requisite for the induction of growth arrest and/or Apoptosis of myeloid precursor cells. This gene has been shown to produce neuronal differentiation in a neuroblastoma cell line. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]