1. Gene
  2. TRPC4AP - transient receptor potential cation channel subfamily C member 4 associated protein Gene

TRPC4AP - transient receptor potential cation channel subfamily C member 4 associated protein Gene

中文名称:瞬时受体电位阳离子通道亚家族 C 成员 4 相关蛋白

种属: Homo sapiens

同用名: TRUSS; TRRP4AP; PPP1R158; C20orf188

基因 ID: 26133 | 基因类型: protein coding

关于 TRPC4AP

Cytogenetic location: 20q11.22 Genomic coordinates (GRCh38): 20:35,002,404-35,092,807 (from NCBI)

This gene has 2 transcripts (splice variants) and 232 orthologues. Ubiquitous expression in placenta (RPKM 20.6), spleen (RPKM 19.3) and 25 other tissues.

功能概要

启用磷酸酶结合活性和泛素连接酶-底物接头活性。通过 C 端 degron 规则途径参与蛋白质泛素化和泛素依赖性蛋白质分解代谢过程。 Cul4A-RING E3 泛素连接酶复合物的一部分。在 Cul4-RING E3 泛素连接酶复合物中具有活性。 [由基因组资源联盟提供,2022 年 4 月]

Enables Phosphatase binding activity and ubiquitin ligase-substrate adaptor activity. Involved in protein ubiquitination and ubiquitin-dependent protein catabolic process via the C-end degron rule pathway. Part of Cul4A-RING E3 ubiquitin Ligase complex. Is active in Cul4-RING E3 ubiquitin Ligase complex. [provided by Alliance of Genome Resources, Apr 2022]

TRPC4AP 基因产物(2)

mRNA Protein Name
NM_015638.3 NP_056453.1 short transient receptor potential channel 4-associated protein isoform a
NM_199368.2 NP_955400.1 short transient receptor potential channel 4-associated protein isoform b
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables phosphatase binding IDA
IDA: 通过直接分析推断
19389623 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
19389623 GOA
enables ubiquitin-like ligase-substrate adaptor activity IDA
IDA: 通过直接分析推断
29779948 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in protein ubiquitination IDA
IDA: 通过直接分析推断
20551172 GOA
involved in ubiquitin-dependent protein catabolic process IDA
IDA: 通过直接分析推断
20551172 GOA
involved in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway IDA
IDA: 通过直接分析推断
29779948 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of Cul4-RING E3 ubiquitin ligase complex IDA
IDA: 通过直接分析推断
29779948 GOA
part of Cul4A-RING E3 ubiquitin ligase complex IDA
IDA: 通过直接分析推断
20551172 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

TRPC4AP 蛋白结构

DUF3689

DUF3689: Protein of unknown function (DUF3689) (407 - 717)

  • 0
  • 200
  • 400
  • 600
  • 797 a.a.
蛋白主名 其他名称

short transient receptor potential channel 4-associated protein

TNF-receptor ubiquitous scaffolding/signaling protein

关联疾病

疾病名称 别名
Alzheimer'S Disease 1

Alzheimer Disease Type 1

Alzheimer'S Disease 1, Early Onset

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus TRPC4AP VGNC VGNC:66584
Mus musculus TRPC4AP MGD MGI:1930751
Canis familiaris TRPC4AP VGNC VGNC:47869
Bos taurus TRPC4AP VGNC VGNC:36384
Macaca mulatta TRPC4AP VGNC VGNC:79014
Rattus norvegicus TRPC4AP RGD RGD:1309914