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  2. EIF2S1 - eukaryotic translation initiation factor 2 subunit alpha Gene

EIF2S1 - eukaryotic translation initiation factor 2 subunit alpha Gene

中文名称:真核翻译起始因子 2 亚基 alpha

种属: Homo sapiens

同用名: EIF2; EIF-2; EIF2A; EIF-2A; EIF-2alpha

基因 ID: 1965 | 基因类型: protein coding

关于 EIF2S1

Cytogenetic location: 14q23.3 Genomic coordinates (GRCh38): 14:67,360,328-67,386,516 (from NCBI)

This gene has 6 transcripts (splice variants) and 238 orthologues. Ubiquitous expression in testis (RPKM 19.0), esophagus (RPKM 15.6) and 25 other tissues.

功能概要

翻译起始因子 EIF2 催化蛋白质合成起始的第一个调节步骤,促进起始 tRNA 与 40S 核糖体亚基的结合。结合以甲硫氨酰-tRNA、EIF2 和 GTP 的三元复合物形式出现。 EIF2 由 3 个不同的亚基组成,即 36-kD EIF2-alpha 亚基 (EIF2S1) 、38-kD EIF2-beta 亚基 (EIF2S2;MIM 603908) 和 52-kD EIF2-gamma 亚基 (EIF2S3;MIM 300161) .三元复合物的形成速率由 EIF2-α 的磷酸化状态调节 (Ernst 等人,1987 [PubMed 2948954]) 。[OMIM 提供,2010 年 2 月]

The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, EIF2, and GTP. EIF2 is composed of 3 nonidentical subunits, the 36-kD EIF2-alpha subunit (EIF2S1), the 38-kD EIF2-beta subunit (EIF2S2; MIM 603908), and the 52-kD EIF2-gamma subunit (EIF2S3; MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of EIF2-alpha (Ernst et al., 1987 [PubMed 2948954]).[supplied by OMIM, Feb 2010]

EIF2S1 基因产物(1)

mRNA Protein Name
NM_004094.5 NP_004085.1 eukaryotic translation initiation factor 2 subunit 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
9431994 GOA
enables ribosome binding IDA
IDA: 通过直接分析推断
17894550 GOA
enables translation initiation factor activity IDA
IDA: 通过直接分析推断
16289705 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in HRI-mediated signaling IDA
IDA: 通过直接分析推断
32132706 GOA
involved in PERK-mediated unfolded protein response IDA
IDA: 通过直接分析推断
33384352 GOA
involved in mitophagy IDA
IDA: 通过直接分析推断
38340717 GOA
involved in regulation of translation in response to endoplasmic reticulum stress IMP
IMP: 通过突变表型推断
18508033 GOA
involved in response to endoplasmic reticulum stress IDA
IDA: 通过直接分析推断
33384352 GOA
involved in response to endoplasmic reticulum stress IMP
IMP: 通过突变表型推断
18508033 GOA
involved in translational initiation IDA
IDA: 通过直接分析推断
16289705 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of eukaryotic translation initiation factor 2 complex IDA
IDA: 通过直接分析推断
23063529 GOA
part of eukaryotic translation initiation factor 2 complex IPI
IPI: 通过物理相互作用推断
31836389 GOA
is active in mitochondrion IDA
IDA: 通过直接分析推断
38340717 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

EIF2S1 蛋白结构

S1

S1: S1 RNA binding domain (14 - 88)

EIF_2_alpha

EIF_2_alpha: Eukaryotic translation initiation factor 2 alpha subunit (130 - 243)

  • 0
  • 100
  • 200
  • 315 a.a.
蛋白主名 其他名称

eukaryotic translation initiation factor 2 subunit 1

eIF-2-alpha

EIF2S1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra EIF2S1 P05198 EIF2S3 Homo sapiens P41091
Anti Tag CoIP
33961781
Intra EIF2S1 P05198 EIF2S3 Homo sapiens P41091
ELISA
16288713
Intra EIF2S1 P05198 EIF2S3 Homo sapiens P41091
Y3H
37507029
Cross EIF2S1 P05198 Eif2ak3 Mus musculus Q9Z2B5
Pull Down
16288713
Cross EIF2S1 P05198 Eif2ak3 Mus musculus Q9Z2B5
Fluorescence Spectr
16288713
Intra EIF2S1 P05198 VAC14 Homo sapiens Q08AM6
Y2H Prey Pooling
32296183
Intra EIF2S1 P05198 VAC14 Homo sapiens Q08AM6
Validated Y2H
32296183
Intra EIF2S1 P05198 VAC14 Homo sapiens Q08AM6
Y2H Array
32296183
Intra EIF2S1 P05198 PRMT7 Homo sapiens Q9NVM4
Validated Y2H
32296183
Intra EIF2S1 P05198 PRMT7 Homo sapiens Q9NVM4
Anti Tag CoIP
33961781
Intra EIF2S1 P05198 ACTN1 Homo sapiens P12814
Validated Y2H
32296183
Intra EIF2S1 P05198 EIF2AK2 Homo sapiens P19525
Pull Down
16288713
Intra EIF2S1 P05198 EIF2S2 Homo sapiens P20042
Density Sedimentation
16932749
Intra EIF2S1 P05198 EIF2S2 Homo sapiens P20042
ELISA
16288713
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Vaccinia
Epiphyseal Dysplasia, Multiple, With Early-Onset Diabetes Mellitus

Wolcott-Rallison Syndrome

Med-Iddm Syndrome

Iddm-Med Syndrome

Wolcott Rallison Syndrome

WRS

Epiphyseal Dysplasia Multiple With Early-Onset Diabetes Mellitus

Early-Onset Diabetes Mellitus With Multiple Epiphyseal Dysplasia

Multiple Epiphyseal Dysplasia With Early-Onset Diabetes Mellitus

Fatty Liver Disease

Alcoholic Fatty Liver

Fatty Liver

Fatty Liver, Alcoholic

Fatty Change Of Liver

Hepatic Lipidosis

Steatosis Of Liver

Fatty Liver Alcoholic

Steatohepatitis

Etoh Fatty Liver

Etoh Fatty Liver Metamorphosis

Fatty Etoh Liver Necrosis

Cowpox

Yaba

Rift Valley Fever

Rfv - [Rift Valley Fever]

Newcastle Disease

Newcastle'S Disease

Pseudo-Fowlpest

Liver Disease

Liver Failure

Liver Diseases

Abnormality Of The Liver

Liver Dysfunction

Disorder Of Liver

Hepatic Disorder

Hepatic Disease

Disease Of Bilirubin Metabolism

Disorder Of Bilirubin Metabolism

Liver Decompensation

Liver Function Failure

Hepatic Failure Nos

Liver Failure Nos

End Stage Liver Disease

Decompensated Liver Failure

Decompensation Of Liver Function

Hepatic Decompensation

Hepatic Insufficiency

Liver Cell Necrosis With Hepatic Failure

Liver Insufficiency

Decompensated Liver Disease

End Stage Liver Failure

Liver Necrosis With Hepatic Failure

Influenza

Flu

Influenza With Non-Respiratory Manifestation

Influenza With Other Manifestations

Influenza, Human

Influenza, Susceptibility To

Seasonal Influenza, Virus Identified

Yellow Fever

Urban Yellow Fever

Jungle Yellow Fever

Sylvatic Yellow Fever

Yf

Yellow Fever, Sylvan

Bronze John

Yellow Jack

Yf- [Yellow Fever]

Febris Flava

Leukoencephalopathy With Vanishing White Matter

Cree Leukoencephalopathy

Vanishing White Matter Disease

Ovarioleukodystrophy

Vanishing White Matter Leukodystrophy

Childhood Ataxia With Central Nervous System Hypomyelinization

Cach

Cach Syndrome

Myelinosis Centralis Diffusa

VWM

Cle

Childhood Ataxia With Central Nervous System Hypomyelination

Childhood Ataxia With Diffuse Central Nervous System Hypomyelination

Cach/Vwm

Cach/Vwm Syndrome

Childhood Ataxia With Central Nervous System Hypomyelination/Vanishing White Matter

Cree Leukoencehalopathy

Late Infantile Cach Syndrome

Juvenile Or Adult Cach Syndrome

Congenital Or Early Infantile Cach Syndrome

Leukodystrophy With Vanishing White Matter

Mehmo Syndrome

Mental Retardation, Epileptic Seizures, Hypogonadism And Hypogenitalism, Microcephaly, And Obesity

MEHMO

Mrxs20

Mrxs25

X-Linked Intellectual Disability-Epileptic Seizures-Hypogenitalism-Microcephaly-Obesity Syndrome

Mrxsbrk

Mental Retardation, X-Linked, Syndromic 20

Mental Retardation, X-Linked, Syndromic 25

Mental Retardation, X-Linked, Syndromic, Borck Type

Syndromic X-Linked Mental Retardation 20

Syndromic X-Linked Mental Retardation 25

Intellectual Disability, Epileptic Seizures, Hypogonadism And Hypogenitalism, Microcephaly, And Obesity

X-Linked Mehmo Syndrome

Viral Infectious Disease

Viral Disease

Arbovirus Infections

Virus Infection

Virus Diseases

Viral Infection

Viral Infections

Virus Infections

Dystonia 16

DYT16

Dyt-Prkra

Dystonia-16

Young-Onset Dystonia-

Early-Onset Dystonia Parkinsonism

Dystonia, Type 16

Beta-Thalassemia

Beta Thalassemia

Cooley'S Anemia

Mediterranean Anemia

Beta Thalassemia Intermedia

Erythroblastic Anemia

Thalassemia, Hispanic Gamma-Delta-Beta

Thalassemia Major

Thalassemia Minor

Beta-Plus-Thalassemia

Thalassemia, Beta

Beta Thalassemia Major

Beta Thalassemia Minor

Thalassemias, Beta-

Microcytemia, Beta Type

Thalassemia, Beta Type

B-THAL

Mediterranean Anaemia

Beta Thalassaemia Syndrome

Mediterranean Disease

Beta Thalassaemia Disease

Melanoma In Congenital Melanocytic Nevus

Malignant Melanoma In Congenital Melanocytic Nevus

Melanocytic Nevi

Nevi Melanocytic

Retinal Degeneration

Degeneration Of Retina

Dystonia

Dystonic Disease

Dystonic Disorder

Dystonia Disorders

Neuroleptic Dyskinesia

Alzheimer Disease, Familial, 1

Alzheimer Disease

Alzheimer'S Disease

Presenile And Senile Dementia

AD1

Alzheimer Disease, Susceptibility To

Alzheimer Disease, Late-Onset, Susceptibility To

Alzheimer Disease 1, Familial

AD

Familial Alzheimer Disease

Alzheimer Disease, Late-Onset

Alzheimers Dementia

Alzheimer Dementia

Alzheimer Sclerosis

Alzheimer Syndrome

Alzheimer-Type Dementia

Dat

Primary Senile Degenerative Dementia

Sdat

Alzheimer Disease 1

Autosomal Dominant Alzheimer Disease

Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

Late Onset Alzheimer Disease

Alzheimers Disease

Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

Late-Onset Alzheimers Disease

Alzheimer'S Disease Pathway Kegg

Dementia Due To Alzheimer'S Disease

Alzheimer Disease Type 1

Alzheimers

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis

ALS

Lou Gehrig Disease

Amyotrophic Lateral Sclerosis Type 1

Charcot Disease

ALS1

Amyotrophic Lateral Sclerosis, Susceptibility To

Fals

Lou Gehrig'S Disease

Mnd

Motor Neuron Disease

Familial Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis 1, Familial

Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

Motor Neuron Disease, Bulbar

Motor Neurone Disease

Amyotrophic Lateral Sclerosis With Dementia

Dementia With Amyotrophic Lateral Sclerosis

Motor Neuron Disease, Amyotrophic Lateral Sclerosis

Sclerosis, Lateral, Amyotrophic

Sclerosis, Lateral, Amyotrophic, Type 1

Amyotrophic Sclerosis

Als - [Amyotrophic Lateral Sclerosis]

Wasting Palsy

Amyotrophic Paralysis

Amyotrophy Lateral Sclerosis

Wasting Paralysis

Spinal Progressive Amyotrophy

Progressive Atrophic Paralysis

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Bos taurus EIF2S1 VGNC VGNC:28390
Canis familiaris EIF2S1 VGNC VGNC:40266
Mus musculus EIF2S1 MGD MGI:95299
Macaca mulatta EIF2S1 VGNC VGNC:72187
Felis catus EIF2S1 VGNC VGNC:61778
Rattus norvegicus EIF2S1 RGD RGD:620963
Others EIF2S1 NCBI