Eif2ak3 - eukaryotic translation initiation factor 2 alpha kinase 3 Gene

中文名称：真核翻译起始因子 2α 激酶 3

种属: Mus musculus

同用名: Pek; Perk

基因 ID: 13666 | 基因类型: protein coding

关于 Eif2ak3

Chromosome 6: 70,821,499-70,882,229 forward strand.GRCm39:CM000999.3

This gene has 5 transcripts (splice variants), 197 orthologues, 8 paralogues and is associated with 41 phenotypes. Ubiquitous expression in placenta adult (RPKM 1.8), colon adult (RPKM 7.9) and 28 other tissues.

功能概要

由该基因编码的蛋白质磷酸化真核翻译起始因子 2 的 α 亚基，导致其失活，从而快速减少翻译起始和抑制整体蛋白质合成。这种蛋白质被认为可以调节线粒体功能。它是一种 I 型膜蛋白，位于内质网 (ER) 中，由错误折叠的蛋白质引起的 ER 应激诱导。人类相似基因的突变与 Wolcott-Rallison 综合征有关。 [RefSeq 提供，2015 年 9 月]

The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in a similar gene in human are associated with Wolcott-Rallison syndrome. [provided by RefSeq, Sep 2015]

Eif2ak3 基因产物(2)

mRNA	Protein	Name
NM_001313918.1	NP_001300847.1	eukaryotic translation initiation factor 2-alpha kinase 3 isoform 2 precursor
NM_010121.3	NP_034251.2	eukaryotic translation initiation factor 2-alpha kinase 3 isoform 1 precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables eukaryotic translation initiation factor 2alpha kinase activity	IDA IDA: 通过直接分析推断	9930704	MGI
enables eukaryotic translation initiation factor 2alpha kinase activity	IGI IGI: 通过遗传相互作用推断	14729979	MGI
enables eukaryotic translation initiation factor 2alpha kinase activity	IMP IMP: 通过突变表型推断	14729979	MGI
enables identical protein binding	IPI IPI: 通过物理相互作用推断	16973740	MGI
enables protein binding	IPI IPI: 通过物理相互作用推断	12610133	MGI
enables protein kinase activity	IDA IDA: 通过直接分析推断	14517290	MGI
enables protein kinase activity	IMP IMP: 通过突变表型推断	15542627	MGI
enables protein serine/threonine kinase activity	IDA IDA: 通过直接分析推断	9930704	MGI

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in ERAD pathway	IMP IMP: 通过突变表型推断	17707796	MGI
involved in PERK-mediated unfolded protein response	IMP IMP: 通过突变表型推断	14729979	MGI
acts upstream of or within SREBP signaling pathway	IDA IDA: 通过直接分析推断	18852460	MGI
acts upstream of or within activation of cysteine-type endopeptidase activity involved in apoptotic process	IMP IMP: 通过突变表型推断	10882126	MGI
acts upstream of or within bone mineralization	IMP IMP: 通过突变表型推断	11997520	MGI
acts upstream of or within calcium-mediated signaling	IMP IMP: 通过突变表型推断	16352659	MGI
involved in cellular response to glucose starvation	IMP IMP: 通过突变表型推断	22915762	MGI
acts upstream of or within chondrocyte development	IMP IMP: 通过突变表型推断	12865332	MGI
involved in eiF2alpha phosphorylation in response to endoplasmic reticulum stress	IMP IMP: 通过突变表型推断	17707796	MGI
acts upstream of or within endoplasmic reticulum organization	IMP IMP: 通过突变表型推断	11430819	MGI
acts upstream of or within endoplasmic reticulum unfolded protein response	IDA IDA: 通过直接分析推断	9930704	MGI
acts upstream of or within endoplasmic reticulum unfolded protein response	IMP IMP: 通过突变表型推断	10882126	MGI
acts upstream of or within fat cell differentiation	IDA IDA: 通过直接分析推断	18852460	MGI
acts upstream of or within insulin-like growth factor receptor signaling pathway	IMP IMP: 通过突变表型推断	12865332	MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IMP IMP: 通过突变表型推断	11430819	MGI
acts upstream of or within lactation	IMP IMP: 通过突变表型推断	18852460	MGI
acts upstream of or within negative regulation of apoptotic process	IMP IMP: 通过突变表型推断	15542627	MGI
acts upstream of or within negative regulation of gene expression	IMP IMP: 通过突变表型推断	23152784	MGI
acts upstream of or within negative regulation of myelination	IMP IMP: 通过突变表型推断	15911877	MGI
acts upstream of or within negative regulation of translation	IDA IDA: 通过直接分析推断	9930704	MGI
acts upstream of or within negative regulation of translation	IGI IGI: 通过遗传相互作用推断	16176978	MGI
acts upstream of or within negative regulation of translation	IMP IMP: 通过突变表型推断	10882126	MGI
involved in negative regulation of translation	IMP IMP: 通过突变表型推断	12610133	MGI
involved in negative regulation of translation in response to endoplasmic reticulum stress	IDA IDA: 通过直接分析推断	9930704	MGI
acts upstream of or within pancreas development	IMP IMP: 通过突变表型推断	11997520	MGI
involved in peptidyl-serine phosphorylation	IDA IDA: 通过直接分析推断	9930704	MGI
acts upstream of or within positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	IGI IGI: 通过遗传相互作用推断	22240901	MGI
involved in positive regulation of gene expression	IMP IMP: 通过突变表型推断	14729979	MGI
involved in positive regulation of glutathione biosynthetic process	IMP IMP: 通过突变表型推断	14978030	MGI
acts upstream of or within positive regulation of protein binding	IMP IMP: 通过突变表型推断	16352659	MGI
involved in positive regulation of protein localization to nucleus	IMP IMP: 通过突变表型推断	14517290	MGI
acts upstream of or within positive regulation of signal transduction	IDA IDA: 通过直接分析推断	18852460	MGI
involved in positive regulation of transcription by RNA polymerase I	IMP IMP: 通过突变表型推断	22915762	MGI
involved in positive regulation of vascular endothelial growth factor production	IMP IMP: 通过突变表型推断	22915762	MGI
acts upstream of or within protein autophosphorylation	IDA IDA: 通过直接分析推断	9930704	MGI
involved in protein autophosphorylation	IDA IDA: 通过直接分析推断	12610133	MGI
acts upstream of or within protein autophosphorylation	IMP IMP: 通过突变表型推断	15542627	MGI
acts upstream of or within protein phosphorylation	IDA IDA: 通过直接分析推断	9930704	MGI
involved in protein phosphorylation	IDA IDA: 通过直接分析推断	14517290	MGI
acts upstream of or within protein phosphorylation	IMP IMP: 通过突变表型推断	10882126	MGI
involved in protein phosphorylation	IMP IMP: 通过突变表型推断	10882126	MGI
involved in regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation	IMP IMP: 通过突变表型推断	11106749	MGI
acts upstream of or within regulation of fatty acid metabolic process	IMP IMP: 通过突变表型推断	18852460	MGI
involved in regulation of translational initiation	IMP IMP: 通过突变表型推断	14729979	MGI
involved in regulation of translational initiation by eIF2 alpha phosphorylation	IDA IDA: 通过直接分析推断	14676213	MGI
involved in regulation of translational initiation by eIF2 alpha phosphorylation	IMP IMP: 通过突变表型推断	10882126	MGI
involved in response to endoplasmic reticulum stress	IDA IDA: 通过直接分析推断	11106749	MGI
involved in response to endoplasmic reticulum stress	IMP IMP: 通过突变表型推断	14978030	MGI
acts upstream of or within skeletal system development	IMP IMP: 通过突变表型推断	11997520	MGI
acts upstream of or within translation	IDA IDA: 通过直接分析推断	12388085	MGI

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	11747369	MGI
located in endoplasmic reticulum	IDA IDA: 通过直接分析推断	11430819	MGI
located in endoplasmic reticulum membrane	IDA IDA: 通过直接分析推断	9930704	MGI
located in endoplasmic reticulum quality control compartment	IDA IDA: 通过直接分析推断	17707796	MGI

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Eif2ak3 蛋白结构

Luminal_EIF2AK3

PKc_like

STKc_EIF2AK3_PERK

0
200
400
600
800
1000
1114 a.a.

蛋白主名

其他名称

eukaryotic translation initiation factor 2-alpha kinase 3

PRKR-like endoplasmic reticulum kinase

pancreatic eIF2-alpha kinase

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-119240	CCT020312	Activator	99.28%	否
HY-RS04244	EIF2AK3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS04245	Eif2ak3 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS04246	Eif2ak3 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Homo sapiens	Eif2ak3	NCBI	NCBI:9451

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

Eif2ak3 - eukaryotic translation initiation factor 2 alpha kinase 3 Gene

关于 Eif2ak3

功能概要

Eif2ak3 基因产物(2)

Eif2ak3 蛋白结构

直系同源

热门区域

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Eif2ak3 - eukaryotic translation initiation factor 2 alpha kinase 3 Gene

关于 Eif2ak3

功能概要

Eif2ak3 基因产物(2)

Eif2ak3 蛋白结构

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z