Eif2ak3 - eukaryotic translation initiation factor 2 alpha kinase 3 Gene

中文名称：真核翻译起始因子 2α 激酶 3

种属: Mus musculus

同用名: Pek; Perk

基因 ID: 13666 | 基因类型: protein coding

关于 Eif2ak3

Chromosome 6: 70,821,499-70,882,229 forward strand.GRCm39:CM000999.3

This gene has 5 transcripts (splice variants), 197 orthologues, 8 paralogues and is associated with 41 phenotypes. Ubiquitous expression in placenta adult (RPKM 1.8), colon adult (RPKM 7.9) and 28 other tissues.

功能概要

由该基因编码的蛋白质磷酸化真核翻译起始因子 2 的 α 亚基，导致其失活，从而快速减少翻译起始和抑制整体蛋白质合成。这种蛋白质被认为可以调节线粒体功能。它是一种 I 型膜蛋白，位于内质网 (ER) 中，由错误折叠的蛋白质引起的 ER 应激诱导。人类相似基因的突变与 Wolcott-Rallison 综合征有关。 [RefSeq 提供，2015 年 9 月]

The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in a similar gene in human are associated with Wolcott-Rallison syndrome. [provided by RefSeq, Sep 2015]

Eif2ak3 基因产物(2)

mRNA	Protein	Name
NM_001313918.1	NP_001300847.1	eukaryotic translation initiation factor 2-alpha kinase 3 isoform 2 precursor
NM_010121.3	NP_034251.2	eukaryotic translation initiation factor 2-alpha kinase 3 isoform 1 precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables eukaryotic translation initiation factor 2alpha kinase activity	IDA IDA: 通过直接分析推断	9930704	MGI
enables eukaryotic translation initiation factor 2alpha kinase activity	IGI IGI: 通过遗传相互作用推断	14729979	MGI
enables eukaryotic translation initiation factor 2alpha kinase activity	IMP IMP: 通过突变表型推断	14729979	MGI
enables identical protein binding	IPI IPI: 通过物理相互作用推断	16973740	MGI
enables protein binding	IPI IPI: 通过物理相互作用推断	12610133	MGI
enables protein kinase activity	IDA IDA: 通过直接分析推断	14517290	MGI
enables protein kinase activity	IMP IMP: 通过突变表型推断	15542627	MGI
enables protein serine/threonine kinase activity	IDA IDA: 通过直接分析推断	9930704	MGI

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in ERAD pathway	IMP IMP: 通过突变表型推断	17707796	MGI
involved in PERK-mediated unfolded protein response	IMP IMP: 通过突变表型推断	14729979	MGI
acts upstream of or within SREBP signaling pathway	IDA IDA: 通过直接分析推断	18852460	MGI
acts upstream of or within activation of cysteine-type endopeptidase activity involved in apoptotic process	IMP IMP: 通过突变表型推断	10882126	MGI
acts upstream of or within bone mineralization	IMP IMP: 通过突变表型推断	11997520	MGI
acts upstream of or within calcium-mediated signaling	IMP IMP: 通过突变表型推断	16352659	MGI
involved in cellular response to glucose starvation	IMP IMP: 通过突变表型推断	22915762	MGI
acts upstream of or within chondrocyte development	IMP IMP: 通过突变表型推断	12865332	MGI
involved in eiF2alpha phosphorylation in response to endoplasmic reticulum stress	IMP IMP: 通过突变表型推断	17707796	MGI
acts upstream of or within endoplasmic reticulum organization	IMP IMP: 通过突变表型推断	11430819	MGI
acts upstream of or within endoplasmic reticulum unfolded protein response	IDA IDA: 通过直接分析推断	9930704	MGI
acts upstream of or within endoplasmic reticulum unfolded protein response	IMP IMP: 通过突变表型推断	10882126	MGI
acts upstream of or within fat cell differentiation	IDA IDA: 通过直接分析推断	18852460	MGI
acts upstream of or within insulin-like growth factor receptor signaling pathway	IMP IMP: 通过突变表型推断	12865332	MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IMP IMP: 通过突变表型推断	11430819	MGI
acts upstream of or within lactation	IMP IMP: 通过突变表型推断	18852460	MGI
acts upstream of or within negative regulation of apoptotic process	IMP IMP: 通过突变表型推断	15542627	MGI
acts upstream of or within negative regulation of gene expression	IMP IMP: 通过突变表型推断	23152784	MGI
acts upstream of or within negative regulation of myelination	IMP IMP: 通过突变表型推断	15911877	MGI
acts upstream of or within negative regulation of translation	IDA IDA: 通过直接分析推断	9930704	MGI
acts upstream of or within negative regulation of translation	IGI IGI: 通过遗传相互作用推断	16176978	MGI
acts upstream of or within negative regulation of translation	IMP IMP: 通过突变表型推断	10882126	MGI
involved in negative regulation of translation	IMP IMP: 通过突变表型推断	12610133	MGI
involved in negative regulation of translation in response to endoplasmic reticulum stress	IDA IDA: 通过直接分析推断	9930704	MGI
acts upstream of or within pancreas development	IMP IMP: 通过突变表型推断	11997520	MGI
involved in peptidyl-serine phosphorylation	IDA IDA: 通过直接分析推断	9930704	MGI
acts upstream of or within positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	IGI IGI: 通过遗传相互作用推断	22240901	MGI
involved in positive regulation of gene expression	IMP IMP: 通过突变表型推断	14729979	MGI
involved in positive regulation of glutathione biosynthetic process	IMP IMP: 通过突变表型推断	14978030	MGI
acts upstream of or within positive regulation of protein binding	IMP IMP: 通过突变表型推断	16352659	MGI
involved in positive regulation of protein localization to nucleus	IMP IMP: 通过突变表型推断	14517290	MGI
acts upstream of or within positive regulation of signal transduction	IDA IDA: 通过直接分析推断	18852460	MGI
involved in positive regulation of transcription by RNA polymerase I	IMP IMP: 通过突变表型推断	22915762	MGI
involved in positive regulation of vascular endothelial growth factor production	IMP IMP: 通过突变表型推断	22915762	MGI
acts upstream of or within protein autophosphorylation	IDA IDA: 通过直接分析推断	9930704	MGI
involved in protein autophosphorylation	IDA IDA: 通过直接分析推断	12610133	MGI
acts upstream of or within protein autophosphorylation	IMP IMP: 通过突变表型推断	15542627	MGI
acts upstream of or within protein phosphorylation	IDA IDA: 通过直接分析推断	9930704	MGI
involved in protein phosphorylation	IDA IDA: 通过直接分析推断	14517290	MGI
acts upstream of or within protein phosphorylation	IMP IMP: 通过突变表型推断	10882126	MGI
involved in protein phosphorylation	IMP IMP: 通过突变表型推断	10882126	MGI
involved in regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation	IMP IMP: 通过突变表型推断	11106749	MGI
acts upstream of or within regulation of fatty acid metabolic process	IMP IMP: 通过突变表型推断	18852460	MGI
involved in regulation of translational initiation	IMP IMP: 通过突变表型推断	14729979	MGI
involved in regulation of translational initiation by eIF2 alpha phosphorylation	IDA IDA: 通过直接分析推断	14676213	MGI
involved in regulation of translational initiation by eIF2 alpha phosphorylation	IMP IMP: 通过突变表型推断	10882126	MGI
involved in response to endoplasmic reticulum stress	IDA IDA: 通过直接分析推断	11106749	MGI
involved in response to endoplasmic reticulum stress	IMP IMP: 通过突变表型推断	14978030	MGI
acts upstream of or within skeletal system development	IMP IMP: 通过突变表型推断	11997520	MGI
acts upstream of or within translation	IDA IDA: 通过直接分析推断	12388085	MGI

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	11747369	MGI
located in endoplasmic reticulum	IDA IDA: 通过直接分析推断	11430819	MGI
located in endoplasmic reticulum membrane	IDA IDA: 通过直接分析推断	9930704	MGI
located in endoplasmic reticulum quality control compartment	IDA IDA: 通过直接分析推断	17707796	MGI

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Eif2ak3 蛋白结构

Luminal_EIF2AK3

PKc_like

STKc_EIF2AK3_PERK

0
200
400
600
800
1000
1114 a.a.

蛋白主名

其他名称

eukaryotic translation initiation factor 2-alpha kinase 3

PRKR-like endoplasmic reticulum kinase

pancreatic eIF2-alpha kinase

Eif2ak3 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	Eif2ak3	Q9Z2B5	EIF2S1	Homo sapiens	P05198	Far-WB	16288713
种属内	Eif2ak3	Q9Z2B5	EIF2S1	Homo sapiens	P05198	FRET	16288713
种属内	Eif2ak3	Q9Z2B5	Eif2s1	Mus musculus	Q6ZWX6	Protein Kinase Assay	28869608
种属内	Eif2ak3	Q9Z2B5	Cnpy2	Mus musculus	Q9QXT0	Anti Tag CoIP	28869608
种属内	Eif2ak3	Q9Z2B5	Eif2ak3	Mus musculus	Q9Z2B5	Solution Sedimentation	16973740
种属内	Eif2ak3	Q9Z2B5	Eif2ak3	Mus musculus	Q9Z2B5	GMS	16973740
种属间	Eif2ak3	Q9Z2B5	HSPA5	Homo sapiens	P11021	Anti Tag CoIP	28869608
种属内	Eif2ak3	Q9Z2B5	Mfn2	Mus musculus	Q80U63	Anti Bait CoIP	23921556
种属内	Eif2ak3	Q9Z2B5	P27958-PRO_0000037569	Hepatitis C virus	P27958-PRO_0000037569	Pull Down	23667408
种属内	Eif2ak3	Q9Z2B5	aspat_myctu	Mycobacterium tuberculosis	O69689	Y2H Array	29165646
种属间	Eif2ak3	Q9Z2B5	P27958-PRO_0000037570	Hepatitis C virus	P27958-PRO_0000037570	Pull Down	23667408

种属间: 跨种属相互作用 种属内: 同种属相互作用

Eif2ak3 抗体

目录号	产品名	应用	反应物种
HY-P81190	Phospho-PERK (Thr980) Antibody	WB, ELISA, IHC-P, IHC-F, FC, ICC/IF	Human, Mouse, Rat

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-119240	CCT020312	Activator	99.05%	否
HY-RS04244	EIF2AK3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS04245	Eif2ak3 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS04246	Eif2ak3 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Homo sapiens	Eif2ak3	NCBI	NCBI:9451

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

Eif2ak3 - eukaryotic translation initiation factor 2 alpha kinase 3 Gene

关于 Eif2ak3

功能概要

Eif2ak3 基因产物(2)

Eif2ak3 蛋白结构

Eif2ak3 蛋白互作信息

Eif2ak3 抗体

直系同源

热门区域

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Eif2ak3 - eukaryotic translation initiation factor 2 alpha kinase 3 Gene

关于 Eif2ak3

功能概要

Eif2ak3 基因产物(2)

Eif2ak3 蛋白结构

Eif2ak3 蛋白互作信息

Eif2ak3 抗体

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z