EIF2S2 - eukaryotic translation initiation factor 2 subunit beta Gene

中文名称：真核翻译起始因子 2 亚基 beta

种属: Homo sapiens

同用名: EIF2; EIF2B; PPP1R67; EIF2beta; eIF-2-beta

基因 ID: 8894 | 基因类型: protein coding

关于 EIF2S2

Cytogenetic location: 20q11.22 Genomic coordinates (GRCh38): 20:34,088,309-34,112,243 (from NCBI)

This gene has 1 transcript (splice variant) and 253 orthologues. Ubiquitous expression in placenta (RPKM 24.2), thyroid (RPKM 22.6) and 25 other tissues.

功能概要

真核翻译起始因子 2 (EIF-2) 通过与 GTP 和起始 tRNA 形成三元复合物并与 40S 核糖体亚基结合，在蛋白质合成的早期步骤中发挥作用。 EIF-2 由 alpha、beta 和 gamma 三个亚基组成，该基因编码的蛋白质代表 beta 亚基。 β 亚基催化 GDP 与 GTP 的交换，GTP 将 EIF-2 复合物再循环用于另一轮启动。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供，2015 年 10 月]

Eukaryotic translation initiation factor 2 (EIF-2) functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA and binding to a 40S ribosomal subunit. EIF-2 is composed of three subunits, alpha, beta, and gamma, with the protein encoded by this gene representing the beta subunit. The beta subunit catalyzes the exchange of GDP for GTP, which recycles the EIF-2 complex for another round of initiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]

EIF2S2 基因产物(3)

mRNA	Protein	Name
NM_001316363.2	NP_001303292.1	eukaryotic translation initiation factor 2 subunit 2 isoform 2
NM_001316364.2	NP_001303293.1	eukaryotic translation initiation factor 2 subunit 2 isoform 3
NM_003908.5	NP_003899.2	eukaryotic translation initiation factor 2 subunit 2 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	11959995	GOA
enables translation initiation factor activity	IDA IDA: 通过直接分析推断	16289705	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cytoplasmic translational initiation	IMP IMP: 通过突变表型推断	31836389	GOA
involved in translational initiation	IDA IDA: 通过直接分析推断	10563826	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	12426392	GOA
part of eukaryotic translation initiation factor 2 complex	IDA IDA: 通过直接分析推断	23063529	GOA
part of eukaryotic translation initiation factor 2 complex	IPI IPI: 通过物理相互作用推断	31836389	GOA
NOT located in nucleus	IDA IDA: 通过直接分析推断	12426392	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

EIF2S2 蛋白结构

eIF-5_eIF-2B

0
100
200
300
333 a.a.

蛋白主名

其他名称

eukaryotic translation initiation factor 2 subunit 2

eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa

EIF2S2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	EIF2S2	P20042	NGF	Homo sapiens	P01138	Validated Y2H	32814053
Intra	EIF2S2	P20042	NGF	Homo sapiens	P01138	Y2H Pooling	32814053
Intra	EIF2S2	P20042	NGF	Homo sapiens	P01138	Y2H Array	32814053
Intra	EIF2S2	P20042	EIF2S3	Homo sapiens	P41091	Anti Tag CoIP	33961781
Intra	EIF2S2	P20042	EIF2S3	Homo sapiens	P41091	ELISA	16288713
Intra	EIF2S2	P20042	EIF2S3	Homo sapiens	P41091	Anti Tag CoIP	28514442
Intra	EIF2S2	P20042	EIF2S1	Homo sapiens	P05198	Anti Tag CoIP	28514442
Intra	EIF2S2	P20042	EIF2S1	Homo sapiens	P05198	ELISA	16288713
Intra	EIF2S2	P20042	EIF2S1	Homo sapiens	P05198	Anti Tag CoIP	33961781
Intra	EIF2S2	P20042	SORL1	Homo sapiens	Q92673	Y2H Array	32814053
Intra	EIF2S2	P20042	SORL1	Homo sapiens	Q92673	Y2H Pooling	32814053
Intra	EIF2S2	P20042	SORL1	Homo sapiens	Q92673	Validated Y2H	32814053
Intra	EIF2S2	P20042	CDC123	Homo sapiens	O75794	Anti Tag CoIP	33961781
Intra	EIF2S2	P20042	CDC123	Homo sapiens	O75794	Anti Tag CoIP	28514442
Intra	EIF2S2	P20042	EIF4G2	Homo sapiens	P78344	Pull Down	16932749
Intra	EIF2S2	P20042	EIF4G2	Homo sapiens	P78344	Anti Tag CoIP	16932749
Intra	EIF2S2	P20042	KAT5	Homo sapiens	Q92993	Y2H Pooling	32814053
Intra	EIF2S2	P20042	KAT5	Homo sapiens	Q92993	Validated Y2H	32814053
Intra	EIF2S2	P20042	KAT5	Homo sapiens	Q92993	Y2H Array	32814053
Intra	EIF2S2	P20042	HTT	Homo sapiens	P42858	Validated Y2H	32814053
Intra	EIF2S2	P20042	HTT	Homo sapiens	P42858	Y2H Array	32814053
Intra	EIF2S2	P20042	HTT	Homo sapiens	P42858	Y2H Pooling	32814053
Intra	EIF2S2	P20042	MAP3K5	Homo sapiens	Q99683	Y2H Array	32814053
Intra	EIF2S2	P20042	MAP3K5	Homo sapiens	Q99683	Validated Y2H	32814053
Intra	EIF2S2	P20042	MAP3K5	Homo sapiens	Q99683	Y2H Pooling	32814053
Intra	EIF2S2	P20042	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Pooling	32814053
Intra	EIF2S2	P20042	PMP22	Homo sapiens	A0A6Q8PF08	Validated Y2H	32814053
Intra	EIF2S2	P20042	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Array	32814053
Intra	EIF2S2	P20042	CHRNA4	Homo sapiens	P43681	Validated Y2H	32814053
Intra	EIF2S2	P20042	CHRNA4	Homo sapiens	P43681	Y2H Array	32814053
Intra	EIF2S2	P20042	CHRNA4	Homo sapiens	P43681	Y2H Pooling	32814053
Intra	EIF2S2	P20042	ATXN1	Homo sapiens	P54253	Validated Y2H	32814053
Intra	EIF2S2	P20042	ATXN1	Homo sapiens	P54253	Y2H Array	32814053
Intra	EIF2S2	P20042	ATXN1	Homo sapiens	P54253	Y2H Pooling	32814053

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Leukoencephalopathy With Vanishing White Matter

Cree Leukoencephalopathy	Vanishing White Matter Disease
Ovarioleukodystrophy	Vanishing White Matter Leukodystrophy
Childhood Ataxia With Central Nervous System Hypomyelinization	Cach
Cach Syndrome	Myelinosis Centralis Diffusa
VWM	Cle
Childhood Ataxia With Central Nervous System Hypomyelination	Childhood Ataxia With Diffuse Central Nervous System Hypomyelination
Cach/Vwm	Cach/Vwm Syndrome
Childhood Ataxia With Central Nervous System Hypomyelination/Vanishing White Matter	Cree Leukoencehalopathy
Late Infantile Cach Syndrome	Juvenile Or Adult Cach Syndrome
Congenital Or Early Infantile Cach Syndrome	Leukodystrophy With Vanishing White Matter

Mehmo Syndrome

Mental Retardation, Epileptic Seizures, Hypogonadism And Hypogenitalism, Microcephaly, And Obesity	MEHMO
Mrxs20	Mrxs25
X-Linked Intellectual Disability-Epileptic Seizures-Hypogenitalism-Microcephaly-Obesity Syndrome	Mrxsbrk
Mental Retardation, X-Linked, Syndromic 20	Mental Retardation, X-Linked, Syndromic 25
Mental Retardation, X-Linked, Syndromic, Borck Type	Syndromic X-Linked Mental Retardation 20
Syndromic X-Linked Mental Retardation 25	Intellectual Disability, Epileptic Seizures, Hypogonadism And Hypogenitalism, Microcephaly, And Obesity
X-Linked Mehmo Syndrome

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS04255	EIF2S2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	EIF2S2	RGD	RGD:735192
Felis catus	EIF2S2	VGNC	VGNC:61779
Mus musculus	EIF2S2	MGD	MGI:1914454
Macaca mulatta	EIF2S2	VGNC	VGNC:84912
Bos taurus	EIF2S2	VGNC	VGNC:28391
Canis familiaris	EIF2S2	VGNC	VGNC:40267

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

EIF2S2 - eukaryotic translation initiation factor 2 subunit beta Gene

关于 EIF2S2

功能概要

EIF2S2 基因产物(3)

EIF2S2 蛋白结构

EIF2S2 蛋白互作信息

关联疾病

直系同源

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EIF2S2 - eukaryotic translation initiation factor 2 subunit beta Gene

关于 EIF2S2

功能概要

EIF2S2 基因产物(3)

EIF2S2 蛋白结构

EIF2S2 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z