MAP3K5 - mitogen-activated protein kinase kinase kinase 5 Gene

中文名称：丝裂原活化蛋白激酶激酶激酶 5

种属: Homo sapiens

同用名: ASK1; MEKK5; MAPKKK5

基因 ID: 4217 | 基因类型: protein coding

关于 MAP3K5

Cytogenetic location: 6q23.3 Genomic coordinates (GRCh38): 6:136,557,046-136,793,091 (from NCBI)

This gene has 3 transcripts (splice variants), 206 orthologues and 2 paralogues. Broad expression in adrenal (RPKM 43.3), ovary (RPKM 21.3) and 23 other tissues.

功能概要

丝裂原活化蛋白激酶 (MAPK) 信号级联包括 MAPK 或细胞外信号调节激酶 (ERK) 、MAPK 激酶 (MKK 或 MEK) 和 MAPK 激酶激酶 (MAPKKK 或 MEKK) 。 MAPKK 激酶/MEKK 磷酸化并激活其下游蛋白激酶 MAPK 激酶/MEK，进而激活 MAPK。这些信号级联的激酶是高度保守的，并且在酵母、果蝇和哺乳动物细胞中存在同系物。 MAPKKK5 包含 1,374 个氨基酸和所有 11 个激酶子域。 Northern 印迹分析显示 MAPKKK5 转录物在人类心脏和胰腺中大量表达。 MAPKKK5 蛋白在体外磷酸化并激活 MKK4 (别名 SERK1、MAPKK4) ，并在 COS 和 293 细胞的瞬时表达过程中激活 c-Jun 氨基末端激酶 (JNK) /应激激活蛋白激酶 (SAPK) ； MAPKKK5 不激活 MAPK/ERK。[RefSeq 提供，2008 年 7 月]

Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 Amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not activate MAPK/ERK. [provided by RefSeq, Jul 2008]

MAP3K5 基因产物(10)

mRNA	Protein	Name
XM_011535839.4	XP_011534141.2	mitogen-activated protein kinase kinase kinase 5 isoform X5
XM_017010873.2	XP_016866362.1	mitogen-activated protein kinase kinase kinase 5 isoform X2
XM_017010872.2	XP_016866361.1	mitogen-activated protein kinase kinase kinase 5 isoform X1
XM_047418785.1	XP_047274741.1	mitogen-activated protein kinase kinase kinase 5 isoform X7
XM_017010877.2	XP_016866366.1	mitogen-activated protein kinase kinase kinase 5 isoform X6
XM_047418787.1	XP_047274743.1	mitogen-activated protein kinase kinase kinase 5 isoform X9
XM_047418784.1	XP_047274740.1	mitogen-activated protein kinase kinase kinase 5 isoform X3
XM_047418786.1	XP_047274742.1	mitogen-activated protein kinase kinase kinase 5 isoform X8
NM_005923.4	NP_005914.1	mitogen-activated protein kinase kinase kinase 5
XM_017010875.2	XP_016866364.1	mitogen-activated protein kinase kinase kinase 5 isoform X4

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables ATP binding	IDA IDA: 通过直接分析推断	17210579	GOA
enables JUN kinase kinase kinase activity	IDA IDA: 通过直接分析推断	11959862	GOA
enables MAP kinase kinase kinase activity	IDA IDA: 通过直接分析推断	15983381	GOA
enables identical protein binding	IPI IPI: 通过物理相互作用推断	9743501	GOA
enables magnesium ion binding	IDA IDA: 通过直接分析推断	17210579	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	9743501	GOA
enables protein domain specific binding	IPI IPI: 通过物理相互作用推断	11096076	GOA
enables protein homodimerization activity	IDA IDA: 通过直接分析推断	11920685	GOA
enables protein kinase activity	IDA IDA: 通过直接分析推断	11096076	GOA
enables protein phosphatase binding	IPI IPI: 通过物理相互作用推断	11959862	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in JNK cascade	IDA IDA: 通过直接分析推断	11959862	GOA
involved in JNK cascade	IMP IMP: 通过突变表型推断	22095282	GOA
involved in MAPK cascade	IDA IDA: 通过直接分析推断	17210579	GOA
involved in cellular response to amino acid starvation	IDA IDA: 通过直接分析推断	11096076	GOA
involved in cellular response to hydrogen peroxide	IDA IDA: 通过直接分析推断	20674765	GOA
involved in intrinsic apoptotic signaling pathway in response to oxidative stress	IDA IDA: 通过直接分析推断	21771788	GOA
involved in neuron intrinsic apoptotic signaling pathway in response to oxidative stress	IGI IGI: 通过遗传相互作用推断	15983381	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	11096076	GOA
involved in positive regulation of JUN kinase activity	IMP IMP: 通过突变表型推断	23000344	GOA
involved in positive regulation of apoptotic process	IDA IDA: 通过直接分析推断	21771788	GOA
involved in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	IDA IDA: 通过直接分析推断	20674765	GOA
involved in positive regulation of protein kinase activity	IDA IDA: 通过直接分析推断	11959862	GOA
involved in protein phosphorylation	IDA IDA: 通过直接分析推断	11096076	GOA
involved in response to endoplasmic reticulum stress	IMP IMP: 通过突变表型推断	23000344	GOA
involved in stress-activated MAPK cascade	IDA IDA: 通过直接分析推断	11096076	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of IRE1-TRAF2-ASK1 complex	IDA IDA: 通过直接分析推断	12050113	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	26095851	GOA
part of protein kinase complex	IDA IDA: 通过直接分析推断	15983381	GOA
part of protein-containing complex	IMP IMP: 通过突变表型推断	11096076	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MAP3K5 蛋白结构

DUF4071

Pkinase

0
300
600
900
1200
1374 a.a.

蛋白主名

其他名称

mitogen-activated protein kinase kinase kinase 5

ASK-1	MAP/ERK kinase kinase 5
MAPK/ERK kinase kinase 5	MEK kinase 5
MEKK 5	apoptosis signal-regulating kinase 1

MAP3K5 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属间	MAP3K5	Q99683	Map3k6	Mus musculus	Q9WTR2	Anti Tag CoIP	17210579
种属间	MAP3K5	Q99683	Map3k6	Mus musculus	Q9WTR2	Y2H	17210579
种属内	MAP3K5	Q99683	LRP8	Homo sapiens	Q14114-3	Validated Y2H	32814053
种属内	MAP3K5	Q99683	LRP8	Homo sapiens	Q14114-3	Y2H Pooling	32814053
种属内	MAP3K5	Q99683	LRP8	Homo sapiens	Q14114-3	Y2H Array	32814053
种属内	MAP3K5	Q99683	ZNF622	Homo sapiens	Q969S3	Comigration in Gel	21771788
种属内	MAP3K5	Q99683	ZNF622	Homo sapiens	Q969S3	Anti Bait CoIP	21771788
种属内	MAP3K5	Q99683	ZNF622	Homo sapiens	Q969S3	Pull Down	21771788
种属内	MAP3K5	Q99683	AKT1	Homo sapiens	P31749	Anti Bait CoIP	11154276
种属内	MAP3K5	Q99683	YWHAH	Homo sapiens	Q04917	CoIP	17700517
种属内	MAP3K5	Q99683	YWHAH	Homo sapiens	Q04917	Y2H	15023544
种属间	MAP3K5	Q99683	Vps28	Mus musculus	Q9D1C8	Y2H	14557248
种属间	MAP3K5	Q99683	Vps28	Mus musculus	Q9D1C8	Anti Tag CoIP	14557248
种属内	MAP3K5	Q99683	YWHAZ	Homo sapiens	P63104	Anti Tag CoIP	25852190
种属内	MAP3K5	Q99683	YWHAZ	Homo sapiens	P63104	Pull Down	15023544
种属内	MAP3K5	Q99683	MCRS1	Homo sapiens	Q96EZ8	Anti Bait CoIP	22609355
种属内	MAP3K5	Q99683	HSPB1	Homo sapiens	P04792	Y2H Pooling	32814053
种属内	MAP3K5	Q99683	HSPB1	Homo sapiens	P04792	Validated Y2H	32814053
种属内	MAP3K5	Q99683	HSPB1	Homo sapiens	P04792	Y2H Array	32814053
种属内	MAP3K5	Q99683	TRAF2	Homo sapiens	Q12933	Pull Down	19805025
种属内	MAP3K5	Q99683	TRAF2	Homo sapiens	Q12933	Anti Tag CoIP	19805025
种属内	MAP3K5	Q99683	TRAF2	Homo sapiens	Q12933	Anti Bait CoIP	19805025
种属内	MAP3K5	Q99683	YWHAE	Homo sapiens	P62258	Y2H	15023544
种属内	MAP3K5	Q99683	YWHAB	Homo sapiens	P31946	Anti Bait CoIP	21771788
种属内	MAP3K5	Q99683	YWHAB	Homo sapiens	P31946	Y2H	15023544
种属内	MAP3K5	Q99683	CIB1	Homo sapiens	Q99828	Anti Bait CoIP	19805025
种属内	MAP3K5	Q99683	SMN1	Homo sapiens	Q16637	Anti Tag CoIP	21496457
种属内	MAP3K5	Q99683	MAP3K5	Homo sapiens	Q99683	CoIP	9743501
种属内	MAP3K5	Q99683	MAP3K5	Homo sapiens	Q99683	GMS	17937911
种属内	MAP3K5	Q99683	MAP3K5	Homo sapiens	Q99683	Solution Sedimentation	17937911
种属内	MAP3K5	Q99683	MAP3K5	Homo sapiens	Q99683	Anti Tag CoIP	19805025
种属内	MAP3K5	Q99683	MAP2K3	Homo sapiens	P46734	Anti Tag CoIP	19805025
种属内	MAP3K5	Q99683	MAP2K3	Homo sapiens	P46734	Anti Bait CoIP	21771788
种属内	MAP3K5	Q99683	MAP3K5	Homo sapiens	Q99683	X-Ray Diffraction	17937911
种属内	MAP3K5	Q99683	HTRA2	Homo sapiens	O43464	Validated Y2H	32814053
种属内	MAP3K5	Q99683	HTRA2	Homo sapiens	O43464	Y2H Array	32814053
种属内	MAP3K5	Q99683	HTRA2	Homo sapiens	O43464	Y2H Pooling	32814053
种属内	MAP3K5	Q99683	TXN	Homo sapiens	P10599	Anti Bait CoIP	19805025
种属内	MAP3K5	Q99683	TXN	Homo sapiens	P10599	Anti Bait CoIP	21771788
种属内	MAP3K5	Q99683	ARRB1	Homo sapiens	P49407	Anti Tag CoIP	19782076
种属内	MAP3K5	Q99683	PRPS1	Homo sapiens	P60891	Y2H Array	32814053
种属内	MAP3K5	Q99683	PRPS1	Homo sapiens	P60891	Validated Y2H	32814053
种属内	MAP3K5	Q99683	PRPS1	Homo sapiens	P60891	Y2H Pooling	32814053
种属内	MAP3K5	Q99683	PPP3R1	Homo sapiens	P63098	Anti Bait CoIP	16648474

种属间: 跨种属相互作用 种属内: 同种属相互作用

MAP3K5 抗体

目录号	产品名	应用	反应物种
HY-P80549	ASK1 Antibody	WB, IHC-P, ICC/IF, FC	Human, Mouse
HY-P80792	Phospho-ASK1 (Ser966) Antibody	WB, IHC-P	Human, Mouse, Rat

关联疾病

疾病名称

别名

Fatty Liver Disease

Alcoholic Fatty Liver	Fatty Liver
Fatty Liver, Alcoholic	Fatty Change Of Liver
Hepatic Lipidosis	Steatosis Of Liver
Fatty Liver Alcoholic	Steatohepatitis
Etoh Fatty Liver	Etoh Fatty Liver Metamorphosis
Fatty Etoh Liver Necrosis

Glottis Squamous Cell Carcinoma

Epidermoid Carcinoma Of The Glottis

Squamous Cell Carcinoma Of Glottis

Non-Alcoholic Fatty Liver Disease

Fatty Liver	Non-Alcoholic Fatty Liver
Nafld	Nonalcoholic Fatty Liver Disease
Nonalcoholic Steatohepatitis	Steatosis
Nafl	Nash
Non-Alcoholic Steatohepatitis	Susceptibility To Nonalcoholic Fatty Liver Disease
Steatohepatitis	Fatty Degeneration
Non-Alcoholic Fatty Liver Disease Without Mention Of Non-Alcoholic Steatohepatitis	Nafld Without Nash
Nafld Without Mention Of Nash

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

Neural Tube Defects

Spina Bifida	Neural Tube Defect
NTD	Neural Tube Defects, Susceptibility To
Spinal Dysraphism	Spina Bifida, Susceptibility To
Rachischisis	Cleft Spine
Open Spine	Hydrocele Spinalis
Neural Tube Defect Nos	Sb - [Spina Bifida]
Spinal Hernia Nos	Spinal Fissure Nos

Pyriform Sinus Cancer

Malignant Neoplasm Of Pyriform Fossa	Malignant Neoplasm Of The Pyriform Fossa
Malignant Tumor Of Pyriform Fossa

Alzheimer Disease, Familial, 1

Alzheimer Disease	Alzheimer'S Disease
Presenile And Senile Dementia	AD1
Alzheimer Disease, Susceptibility To	Alzheimer Disease, Late-Onset, Susceptibility To
Alzheimer Disease 1, Familial	AD
Familial Alzheimer Disease	Alzheimer Disease, Late-Onset
Alzheimers Dementia	Alzheimer Dementia
Alzheimer Sclerosis	Alzheimer Syndrome
Alzheimer-Type Dementia	Dat
Primary Senile Degenerative Dementia	Sdat
Alzheimer Disease 1	Autosomal Dominant Alzheimer Disease
Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy	Late Onset Alzheimer Disease
Alzheimers Disease	Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy
Late-Onset Alzheimers Disease	Alzheimer'S Disease Pathway Kegg
Dementia Due To Alzheimer'S Disease	Alzheimer Disease Type 1
Alzheimers

Glioblastoma Classical Subtype

Liver Disease

Liver Failure	Liver Diseases
Abnormality Of The Liver	Liver Dysfunction
Disorder Of Liver	Hepatic Disorder
Hepatic Disease	Disease Of Bilirubin Metabolism
Disorder Of Bilirubin Metabolism	Liver Decompensation
Liver Function Failure	Hepatic Failure Nos
Liver Failure Nos	End Stage Liver Disease
Decompensated Liver Failure	Decompensation Of Liver Function
Hepatic Decompensation	Hepatic Insufficiency
Liver Cell Necrosis With Hepatic Failure	Liver Insufficiency
Decompensated Liver Disease	End Stage Liver Failure
Liver Necrosis With Hepatic Failure

Diabetes Mellitus

Diabetes

Partial Third-Nerve Palsy

Partial Third Nerve Palsy	Third Nerve Palsy With Pupil Sparing
Third Or Oculomotor Nerve Palsy, Partial	Oculomotor Nerve Diseases
Oculomotor Nerve Paralysis

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS08058	MAP3K5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS08059	Map3k5 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS08060	Map3k5 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	MAP3K5	MGD	MGI:1346876
Macaca mulatta	MAP3K5	VGNC	VGNC:74495
Canis familiaris	MAP3K5	VGNC	VGNC:42975
Felis catus	MAP3K5	VGNC	VGNC:68159
Rattus norvegicus	MAP3K5	RGD	RGD:1306565
Bos taurus	MAP3K5	VGNC	VGNC:31198
Others	MAP3K5	NCBI

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2025 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4