1. Gene
  2. ZNF622 - zinc finger protein 622 Gene

ZNF622 - zinc finger protein 622 Gene

中文名称:锌指蛋白 622

种属: Homo sapiens

同用名: ZPR9

基因 ID: 90441 | 基因类型: protein coding

关于 ZNF622

Cytogenetic location: 5p15.1 Genomic coordinates (GRCh38): 5:16,451,519-16,465,800 (from NCBI)

This gene has 1 transcript (splice variant) and 215 orthologues. Ubiquitous expression in heart (RPKM 14.7), colon (RPKM 14.5) and 25 other tissues.

功能概要

启用 RNA 结合活性。参与多个过程,包括响应氧化应激的内在凋亡信号通路; JNK 级联的正调控;和激酶活性的正调节。位于高尔基体;胞质溶胶;和核腔。 [由基因组资源联盟提供,2022 年 4 月]

Enables RNA binding activity. Involved in several processes, including intrinsic apoptotic signaling pathway in response to oxidative stress; positive regulation of JNK cascade; and positive regulation of kinase activity. Located in Golgi apparatus; cytosol; and nuclear lumen. [provided by Alliance of Genome Resources, Apr 2022]

ZNF622 基因产物(1)

mRNA Protein Name
NM_033414.3 NP_219482.1 cytoplasmic 60S subunit biogenesis factor ZNF622
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables preribosome binding IDA
IDA: 通过直接分析推断
32669547 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
21771788 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in intrinsic apoptotic signaling pathway in response to oxidative stress IDA
IDA: 通过直接分析推断
21771788 GOA
involved in positive regulation of JNK cascade IMP
IMP: 通过突变表型推断
21771788 GOA
involved in positive regulation of MAPK cascade IDA
IDA: 通过直接分析推断
21771788 GOA
involved in positive regulation of apoptotic process IDA
IDA: 通过直接分析推断
21771788 GOA
involved in positive regulation of kinase activity IDA
IDA: 通过直接分析推断
21771788 GOA
involved in ribosomal large subunit biogenesis IDA
IDA: 通过直接分析推断
33711283 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

ZNF622 蛋白结构

zf-C2H2_jaz

zf-C2H2_jaz: Zinc-finger double-stranded RNA-binding (68 - 91)

zf-C2H2_2

zf-C2H2_2: C2H2 type zinc-finger (2 copies) (253 - 352)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 477 a.a.
蛋白主名 其他名称

cytoplasmic 60S subunit biogenesis factor ZNF622

zinc finger-like protein 9

ZNF622 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
ZNF622 Q969S3 BEND7 Homo sapiens Q8N7W2-2
Y2H Array
32296183
种属内
ZNF622 Q969S3 BEND7 Homo sapiens Q8N7W2-2
Y2H Prey Pooling
32296183
种属内
ZNF622 Q969S3 MACROH2A1 Homo sapiens O75367
Y2H Array
32296183
种属内
ZNF622 Q969S3 MACROH2A1 Homo sapiens O75367
Y2H Prey Pooling
32296183
种属内
ZNF622 Q969S3 MAP3K5 Homo sapiens Q99683
Comigration in Gel
21771788
种属内
ZNF622 Q969S3 MAP3K5 Homo sapiens Q99683
In Gel Kinase Assay
21771788
种属内
ZNF622 Q969S3 MAP3K5 Homo sapiens Q99683
Anti Bait CoIP
21771788
种属内
ZNF622 Q969S3 MAP3K5 Homo sapiens Q99683
Pull Down
21771788
种属间: 跨种属相互作用 种属内: 同种属相互作用

直系同源

种属 基因名 来源 基因 ID
Canis familiaris ZNF622 VGNC VGNC:48777
Rattus norvegicus ZNF622 RGD RGD:1309146
Macaca mulatta ZNF622 VGNC VGNC:110420
Felis catus ZNF622 VGNC VGNC:67338
Bos taurus ZNF622 VGNC VGNC:37315
Mus musculus ZNF622 MGD MGI:1289282