TRAF2 - TNF receptor associated factor 2 Gene

中文名称：TNF 受体相关因子 2

种属: Homo sapiens

同用名: TRAP; TRAP3; RNF117; MGC:45012

关于 TRAF2

功能概要

该基因编码的蛋白质是 TNF 受体相关因子 (TRAF) 蛋白质家族的成员。 TRAF 蛋白与 TNF 受体超家族成员结合并介导信号转导。该蛋白直接与 TNF 受体相互作用，并与 TRAF1 形成异二聚体复合物。这种蛋白质是 TNF-α 介导的 MAPK8/JNK 和 NF-kappaB 激活所必需的。由该蛋白和 TRAF1 形成的蛋白复合物与凋亡抑制蛋白 (IAP) 相互作用，并充当来自 TNF 受体的抗凋亡信号的介质。这种蛋白质与 TRADD (一种 TNF 受体相关的细胞凋亡信号转导) 的相互作用确保募集 IAP 以直接抑制 Caspase 激活。 BIRC2/c-IAP1 是一种具有泛素连接酶活性的细胞凋亡抑制剂，可以去泛素化并诱导该蛋白的降解，从而增强 TNF 诱导的细胞凋亡。已发现该基因的多个选择性剪接转录物变体，但仅确定了一个转录物的生物学有效性。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a member of the TNF Receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF Receptor Superfamily. This protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF Receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of Caspase activation. BIRC2/c-IAP1, an Apoptosis inhibitor possessing ubiquitin Ligase activity, can unbiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced Apoptosis. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of only one transcript has been determined. [provided by RefSeq, Jul 2008]