2. Gene
  3. CRY2 - cryptochrome circadian regulator 2 Gene

CRY2 - cryptochrome circadian regulator 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：隐花色素昼夜节律调节因子 2

种属: Homo sapiens

同用名: HCRY2; PHLL2

基因 ID: 1408 | 基因类型: protein coding

关于 CRY2

Cytogenetic location: 11p11.2 Genomic coordinates (GRCh38): 11:45,847,118-45,883,244 (from NCBI)

This gene has 12 transcripts (splice variants), 208 orthologues and 1 paralogue. Ubiquitous expression in heart (RPKM 24.1), brain (RPKM 22.3) and 25 other tissues.

功能概要

该基因编码一种黄素腺嘌呤二核苷酸结合蛋白，它是调节生物钟的昼夜节律核心振荡器复合体的关键组成部分。该基因被 CLOCK/ARNTL 异二聚体上调，但随后使用 PER/CRY 异二聚体与 CLOCK/ARNTL 相互作用在反馈回路中抑制这种上调。该基因的多态性与睡眠模式的改变有关。编码的蛋白质在植物和动物中广泛保存。已发现该基因的两个转录本变体编码不同的亚型。[RefSeq 提供，2014 年 2 月]

This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across Plants and Animals. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]

CRY2 基因产物(2)

mRNA Protein Name
NM_001127457.3 NP_001120929.1 cryptochrome-2 isoform 2
NM_021117.5 NP_066940.3 cryptochrome-2 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
NOT enables DNA (6-4) photolyase activity IDA
IDA: 通过直接分析推断
8909283 GOA
enables DNA binding IDA
IDA: 通过直接分析推断
12627958 GOA
enables damaged DNA binding IDA
IDA: 通过直接分析推断
12627958 GOA
NOT enables deoxyribodipyrimidine photo-lyase activity IDA
IDA: 通过直接分析推断
8909283 GOA
enables phosphatase binding IPI
IPI: 通过物理相互作用推断
9383998 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
9383998 GOA
enables single-stranded DNA binding IDA
IDA: 通过直接分析推断
12627958 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
12397359 GOA
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
12397359 GOA
NOT involved in photoreactive repair IDA
IDA: 通过直接分析推断
12627958 GOA
acts upstream of or within regulation of sodium-dependent phosphate transport IDA
IDA: 通过直接分析推断
9753616 GOA
involved in response to light stimulus IMP
IMP: 通过突变表型推断
15751956 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in extracellular region IDA
IDA: 通过直接分析推断
9753616 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CRY2 蛋白结构

DNA_photolyase

DNA_photolyase: DNA photolyase (45 - 198)

FAD_binding_7

FAD_binding_7: FAD binding domain of DNA photolyase (252 - 528)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 614 a.a.
蛋白主名 其他名称

cryptochrome-2

cryptochrome 2 (photolyase-like)

关联疾病

疾病名称 别名
Advanced Sleep Phase Syndrome

Fasps

Familial Advanced Sleep-Phase Syndrome

Advanced Sleep Phase Syndrome, Familial

Familial Advanced Sleep Phase Syndrome

Sleep Phase Syndrome, Advanced, Familial

Advanced Sleep-Phase Syndrome, Familial
Delayed Sleep Phase Disorder

Delayed Sleep Phase Syndrome

Delayed Sleep Phase Syndrome, Susceptibility To

DSPD

Delayed Sleep Phase Disorder, Susceptibility To

DSPS

Sleep Phase, Delayed, Disorder

Sleep Phase Syndrome, Delayed, Susceptibility To
Sleep Disorder

Sleep Disorders

Non-Organic Sleep Disorder
Major Depressive Disorder

Seasonal Affective Disorder

Unipolar Depression

Depression

MDD

Depressive Disorder

Unipolar Depression, Susceptibility To

Major Depressive Disorder 1

Major Depressive Disorder, Response To Citalopram Therapy In

Major Depressive Disorder 2

Winter Depression

Single Major Depressive Episode

Sad

Clinical Depression

Major Depression

Depressive Syndrome

Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment

Seasonal Affective Disorder, Susceptibility To

Recurrent Major Depression

Affective Disorder, Seasonal

Depression In A Seasonal Pattern

Depression

Seasonal

Major Depressive Disorder With A Seasonal Pattern

Seasonal Depression

Seasonal Mood Disorder

Mental Depression

Recurrent Major Depressive Episodes
Bipolar Disorder

Bipolar Depression

Manic Disorder

Depression, Bipolar

Bipolar Disorder Manic Phase

Depressive-Manic Psych.

Manic Bipolar Affective Disorder

Manic Bipolar I Disorder

Manic Depression

Manic Depressive Disorder

Mixed Bipolar Disorder

Bipolar Affective Disorder

Bipolar Affective Psychosis

Bipolar Spectrum Disorder

Manic Depressive Illness

Depression Bipolar

Bipolar Disorder, Mixed

Major Affective Disorder

Major Affective Disorder 1

Major Affective Disorder 2
Dysthymic Disorder

Dysthymia

Chronic Depressive Disorder

Chronic Depression

Depressive Personality

Depressive Personality Disorder

Persistent Depressive Disorder

Persistent Depression
Diabetes Mellitus

Diabetes
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Approval
生物活性分子 (2)
目录号 产品名 作用方式
纯度 是否罕见病
HY-B0318 Metronidazole 99.92% 是
HY-B0318A Metronidazole hydrochloride / 否
Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-108468 KL001 99.68% 否
HY-115672 KS15 99.40% 否
HY-134194 KL201 98.15% 否
HY-RS03205 CRY2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus CRY2 VGNC VGNC:27731
Canis familiaris CRY2 VGNC VGNC:39634
Mus musculus CRY2 MGD MGI:1270859
Felis catus CRY2 VGNC VGNC:61196
Rattus norvegicus CRY2 RGD RGD:620935
Macaca mulatta CRY2 VGNC VGNC:71500
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