SDCBP2 - syndecan binding protein 2 Gene

中文名称：聚糖结合蛋白 2

种属: Homo sapiens

同用名: ST2; ST-2; SITAC; SITAC18

关于 SDCBP2

功能概要

该基因编码的蛋白质包含两个 II 类 PDZ 结构域。 PDZ 结构域通过结合跨膜蛋白的细胞质 C 末端促进蛋白质-蛋白质相互作用，而含有 PDZ 的蛋白质介导细胞信号传导和蛋白质复合物的组织。编码的蛋白质与磷脂酰肌醇 4、5-二磷酸 (PIP2) 结合，并在核 PIP2 组织和细胞分裂中发挥作用。已经观察到该基因编码多种亚型的可变剪接转录物变体。该基因与上游 FKBP1A (FK506 结合蛋白 1A，12kDa) 基因之间也存在通读转录，如 GeneID：100528031 所示。[RefSeq 提供，2011 年 9 月]

The protein encoded by this gene contains two class II PDZ domains. PDZ domains facilitate protein-protein interactions by binding to the cytoplasmic C-terminus of transmembrane proteins, and PDZ-containing proteins mediate cell signaling and the organization of protein complexes. The encoded protein binds to phosphatidylinositol 4, 5-bisphosphate (PIP2) and plays a role in nuclear PIP2 organization and cell division. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Read-through transcription also exists between this gene and the upstream FKBP1A (FK506 binding protein 1A, 12kDa) gene, as represented in GeneID:100528031. [provided by RefSeq, Sep 2011]