2. Gene
  3. TNP1 - transition protein 1 Gene

TNP1 - transition protein 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：过渡蛋白 1

种属: Homo sapiens

同用名: TP1

基因 ID: 7141 | 基因类型: protein coding

关于 TNP1

Cytogenetic location: 2q35 Genomic coordinates (GRCh38): 2:216,859,458-216,860,064 (from NCBI)

This gene has 1 transcript (splice variant) and 83 orthologues. Restricted expression toward testis (RPKM 903.2).

功能概要

Transition protein-1 是单倍体基因组的精子细胞特异性产物，它取代组蛋白并在成熟精子中被鱼精蛋白取代 (参见 PRM1、MIM 182880；PRM2、MIM 182890) (Luerssen 等人，1990 [PubMed 2249851) ]) .[OMIM 提供，2008 年 3 月]

Transition protein-1 is a spermatid-specific product of the haploid genome which replaces histone and is itself replaced in the mature sperm by the protamines (see PRM1, MIM 182880; PRM2, MIM 182890) (Luerssen et al., 1990 [PubMed 2249851]).[supplied by OMIM, Mar 2008]

TNP1 基因产物(1)

mRNA Protein Name
NM_003284.4 NP_003275.1 spermatid nuclear transition protein 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA binding IMP
IMP: 通过突变表型推断
12743712 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in chromatin remodeling IDA
IDA: 通过直接分析推断
12743712 GOA
involved in flagellated sperm motility IMP
IMP: 通过突变表型推断
10781074 GOA
involved in heterochromatin formation IEP
IEP: 通过表达模式推断
11315969 GOA
involved in negative regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
12743712 GOA
involved in nucleosome disassembly IMP
IMP: 通过突变表型推断
10781074 GOA
involved in sexual reproduction IMP
IMP: 通过突变表型推断
10781074 GOA
involved in single strand break repair IDA
IDA: 通过直接分析推断
12743712 GOA
involved in spermatid development IDA
IDA: 通过直接分析推断
12743712 GOA
involved in spermatid nucleus elongation IMP
IMP: 通过突变表型推断
10781074 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of nucleosome IDA
IDA: 通过直接分析推断
12743712 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TNP1 蛋白结构

TP1

TP1: Nuclear transition protein 1 (2 - 55)

  • 0
  • 55 a.a.
蛋白主名 其他名称

spermatid nuclear transition protein 1

STP-1

TNP1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
TNP1 P09430 DVL3 Homo sapiens Q92997
Y2H Array
32296183
种属内
TNP1 P09430 DVL3 Homo sapiens Q92997
Y2H Prey Pooling
32296183
种属内
TNP1 P09430 DVL3 Homo sapiens Q92997
Validated Y2H
32296183
种属内
TNP1 P09430 SDCBP2 Homo sapiens Q9H190
Y2H Array
31515488
种属内
TNP1 P09430 SDCBP2 Homo sapiens Q9H190
Y2H Prey Pooling
25416956
种属内
TNP1 P09430 SDCBP2 Homo sapiens Q9H190
Validated Y2H
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Male Infertility

Infertility, Male

Infertility Male

Male Sterility

Absolute Infertility
Spermatogenic Failure

Azoospermia

Spgf

Spermatogenic Failure, Susceptibility To

Absent Sperm

Aspermatogenesis

Infertility Due To Azoospermia

Hypospermatogenesis

Azoospermatism
Spermatogenic Failure, X-Linked, 1

Sertoli Cell-Only Syndrome

Germinal Cell Aplasia

Del Castillo Syndrome

SPGFX1

X-Linked Spermatogenic Failure 1

Congenital Absence Of Germinal Epithelium Of Testes
Infertility
Pelvic Varices

Varix Of Pelvis

Pelvic Varicose Vein
Oligospermia
Cryptorchidism, Unilateral Or Bilateral

Cryptorchidism

Undescended Testicle

Undescended Testis

Cryptorchism

Undescended Testicles

CRYPTO

Impaired Testicular Descent

Cryptosporidiosis

Retained Testis

Unilateral Cryptorchidism

Unilateral Undescended Testis

Nondescent Unilateral Testicle

Unilateral Cryptorchism

Ectopic Testis, Unilateral

Bilateral Cryptorchidism

Bilateral Cryptorchism

Bilateral Nondescent Testicle

Bilateral Undescended Testes

Bilateral Ectopic Testes
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14857 TNP1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus TNP1 RGD RGD:3884
Macaca mulatta TNP1 VGNC VGNC:104561
Bos taurus TNP1 VGNC VGNC:36197
Canis familiaris TNP1 VGNC VGNC:47693
Felis catus TNP1 VGNC VGNC:80389
Mus musculus TNP1 MGD MGI:98784
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