YTHDC1 - YTH domain containing 1 Gene

中文名称：含 YTH 域 1

种属: Homo sapiens

同用名: YT521; YT521-B

基因 ID: 91746 | 基因类型: protein coding

关于 YTHDC1

Cytogenetic location: 4q13.2 Genomic coordinates (GRCh38): 4:68,310,387-68,350,090 (from NCBI)

This gene has 7 transcripts (splice variants), 1 gene allele, 204 orthologues and 3 paralogues. Ubiquitous expression in bone marrow (RPKM 22.7), ovary (RPKM 15.2) and 25 other tissues.

功能概要

启用含 N6-甲基腺苷的 RNA 结合活性。参与细胞核的 mRNA 输出； mRNA 剪接位点选择；和基因表达的调控。位于核斑点和质膜。 [由基因组资源联盟提供，2022 年 4 月]

Enables N6-methyladenosine-containing RNA binding activity. Involved in mRNA export from nucleus; mRNA splice site selection; and regulation of gene expression. Located in nuclear speck and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

YTHDC1 基因产物(3)

mRNA	Protein	Name
NM_001031732.4	NP_001026902.1	YTH domain-containing protein 1 isoform 1
NM_001330698.2	NP_001317627.1	YTH domain-containing protein 1 isoform 3
NM_133370.4	NP_588611.2	YTH domain-containing protein 1 isoform 2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables N6-methyladenosine-containing RNA reader activity	IDA IDA: 通过直接分析推断	25242552	GOA
enables RNA binding	IDA IDA: 通过直接分析推断	20167602	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	15345239	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in dosage compensation by inactivation of X chromosome	IDA IDA: 通过直接分析推断	27602518	GOA
involved in mRNA export from nucleus	IDA IDA: 通过直接分析推断	28984244	GOA
involved in mRNA splice site recognition	IDA IDA: 通过直接分析推断	20167602	GOA
involved in regulation of mRNA splicing, via spliceosome	IDA IDA: 通过直接分析推断	26876937	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in nuclear speck	IDA IDA: 通过直接分析推断	26876937	GOA
located in nucleus	IDA IDA: 通过直接分析推断	20167602	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

YTHDC1 蛋白结构

YTH

0
200
400
600
727 a.a.

蛋白主名

其他名称

YTH domain-containing protein 1

putative splicing factor YT521

YTHDC1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	YTHDC1	Q96MU7	RBMY1A1	Homo sapiens	P0DJD3-2	Y2H Prey Pooling	32296183
种属内	YTHDC1	Q96MU7	RBMY1A1	Homo sapiens	P0DJD3-2	Y2H Array	32296183
种属内	YTHDC1	Q96MU7	KRTAP10-6	Homo sapiens	P60371	Y2H Array	32296183
种属内	YTHDC1	Q96MU7	KRTAP10-6	Homo sapiens	P60371	Y2H Prey Pooling	32296183
种属内	YTHDC1	Q96MU7	PHF19	Homo sapiens	Q5T6S3	Y2H Prey Pooling	32296183
种属内	YTHDC1	Q96MU7	PHF19	Homo sapiens	Q5T6S3	Y2H Array	32296183
种属内	YTHDC1	Q96MU7	HNRNPK	Homo sapiens	P61978	Y2H Array	25416956
种属内	YTHDC1	Q96MU7	HNRNPK	Homo sapiens	P61978	Y2H Array	29892012
种属内	YTHDC1	Q96MU7	ANKRD28	Homo sapiens	O15084	Y2H Array	32296183
种属内	YTHDC1	Q96MU7	ANKRD28	Homo sapiens	O15084	Y2H Prey Pooling	32296183
种属内	YTHDC1	Q96MU7	SRPK1	Homo sapiens	Q96SB4	BiFC	23602568
种属内	YTHDC1	Q96MU7	SRPK2	Homo sapiens	P78362	Anti Tag CoIP	23602568
种属内	YTHDC1	Q96MU7	HNRNPK	Homo sapiens	P61978-2	Y2H Prey Pooling	32296183
种属内	YTHDC1	Q96MU7	HNRNPK	Homo sapiens	P61978-2	Y2H Array	32296183
种属内	YTHDC1	Q96MU7	KHDRBS3	Homo sapiens	O75525	Y2H Prey Pooling	32296183
种属内	YTHDC1	Q96MU7	KHDRBS3	Homo sapiens	O75525	Y2H Array	32296183
种属内	YTHDC1	Q96MU7	TRA2B	Homo sapiens	P62995	Y2H Array	32296183
种属内	YTHDC1	Q96MU7	TRA2B	Homo sapiens	P62995	Y2H Prey Pooling	32296183
种属内	YTHDC1	Q96MU7	DVL3	Homo sapiens	Q92997	Y2H Prey Pooling	25416956
种属内	YTHDC1	Q96MU7	DVL3	Homo sapiens	Q92997	Validated Y2H	25416956
种属内	YTHDC1	Q96MU7	DVL3	Homo sapiens	Q92997	Y2H Prey Pooling	32296183
种属内	YTHDC1	Q96MU7	DVL3	Homo sapiens	Q92997	Y2H Array	25416956
种属内	YTHDC1	Q96MU7	DVL3	Homo sapiens	Q92997	Y2H Array	32296183
种属内	YTHDC1	Q96MU7	SDCBP2	Homo sapiens	Q9H190	Validated Y2H	32296183
种属内	YTHDC1	Q96MU7	SDCBP2	Homo sapiens	Q9H190	Y2H Array	25416956
种属内	YTHDC1	Q96MU7	SDCBP2	Homo sapiens	Q9H190	Y2H Array	32296183
种属内	YTHDC1	Q96MU7	SDCBP2	Homo sapiens	Q9H190	Y2H Array	31515488
种属内	YTHDC1	Q96MU7	SDCBP2	Homo sapiens	Q9H190	Validated Y2H	25416956
种属内	YTHDC1	Q96MU7	SDCBP2	Homo sapiens	Q9H190	Y2H Prey Pooling	32296183
种属内	YTHDC1	Q96MU7	KHDRBS2	Homo sapiens	Q5VWX1	Y2H Array	32296183
种属内	YTHDC1	Q96MU7	KHDRBS2	Homo sapiens	Q5VWX1	Y2H Prey Pooling	25416956
种属内	YTHDC1	Q96MU7	KHDRBS2	Homo sapiens	Q5VWX1	Validated Y2H	25416956
种属内	YTHDC1	Q96MU7	KHDRBS2	Homo sapiens	Q5VWX1	Y2H Prey Pooling	32296183
种属内	YTHDC1	Q96MU7	CLK2	Homo sapiens	P49760	Y2H Array	32296183
种属内	YTHDC1	Q96MU7	CLK2	Homo sapiens	P49760	Y2H Prey Pooling	32296183
种属内	YTHDC1	Q96MU7	PICK1	Homo sapiens	Q9NRD5	Y2H Prey Pooling	32296183
种属内	YTHDC1	Q96MU7	PICK1	Homo sapiens	Q9NRD5	Validated Y2H	32296183
种属内	YTHDC1	Q96MU7	PICK1	Homo sapiens	Q9NRD5	Y2H Array	32296183
种属内	YTHDC1	Q96MU7	RBMY1F	Homo sapiens	Q15415	Y2H Prey Pooling	25416956
种属内	YTHDC1	Q96MU7	RBMY1F	Homo sapiens	Q15415	Y2H Prey Pooling	32296183
种属内	YTHDC1	Q96MU7	RBMY1F	Homo sapiens	Q15415	Y2H Array	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Hepatoblastoma

Wilms Tumor 1

Nephroblastoma	Wilms Tumor
WT1	Wilms' Tumor
Bilateral Wilms Tumor	Wilms Tumor, Type 1
Wilms Tumor, Somatic	Adult Nephroblastoma
Wt1 Disorder	Renal Embryonic Tumor
Adult Kidney Wilms Tumor	Childhood Kidney Wilms Tumor
Nonanaplastic Kidney Wilms Tumor

Autism Spectrum Disorder

Asd	Autism Spectrum Disorders
Autistic Continuum	Pervasive Developmental Disorder
Pervasive Development Disorder	Autistic Behavior
Autistic Disorder	Autistic
Autistic Disorder Of Childhood Onset	Infantile Autism
Childhood Autism	Kanner Syndrome
Pervasive Developmental Delay Nos	Pervasive Developmental Disorder, Not Otherwise Specified

Leukemia, Acute Myeloid

Acute Myeloid Leukemia	Leukemia, Acute Myelogenous
Acute Myelogenous Leukemia	AML
Leukemia, Acute Myeloid, Susceptibility To	Acute Myeloblastic Leukemia
Leukemia, Acute Myeloid, Reduced Survival In, Somatic	Acute Myeloid Leukaemia
Leukemia, Myelocytic, Acute	Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome
Secondary Aml	Acute Myelocytic Leukemia
Acute Myeloid Leukemia, Somatic	Leukemia, Acute Myeloid, Somatic
Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic	Acute Myeloblastic Leukaemia
Acute Myelogenous Leukaemia	Aml - Acute Myeloid Leukemia
Acute Myeloid Leukemia With Cebpa Somatic Mutations	Aml With Cebpa Somatic Mutations
Inherited Acute Myeloid Leukemia	Familial Aml
Inherited Aml	Pure Familial Aml
Pure Familial Acute Myeloid Leukemia	Secondary Acute Myeloid Leukemia
Therapy-Related Aml And Myelodysplastic Syndrome	Acute Myeloid Leukemia, Secondary
Acute Non-Lymphoblastic Leukemia	Acute Non-Lymphocytic Leukemia
Acute Biphenotypic Leukemia	Acute Undifferentiated Leukemia
Acute Myeloblastic Leukaemia With Multilineage Dysplasia	Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission
Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-158974	YTHDC1-IN-1		99.44%	否
HY-164607	YL-5092	Inhibitor	99.83%	否
HY-RS15935	YTHDC1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-168610	YTH-IN-1		/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	YTHDC1	MGD	MGI:2443713
Rattus norvegicus	YTHDC1	RGD	RGD:621706
Canis familiaris	YTHDC1	VGNC	VGNC:48503
Felis catus	YTHDC1	VGNC	VGNC:67150
Macaca mulatta	YTHDC1	VGNC	VGNC:79860
Bos taurus	YTHDC1	VGNC	VGNC:37039

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

YTHDC1 - YTH domain containing 1 Gene

关于 YTHDC1

功能概要

YTHDC1 基因产物(3)

YTHDC1 蛋白结构

YTHDC1 蛋白互作信息

关联疾病

直系同源

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YTHDC1 - YTH domain containing 1 Gene

关于 YTHDC1

功能概要

YTHDC1 基因产物(3)

YTHDC1 蛋白结构

YTHDC1 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

N

Q

S

T

X

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