SRPK1 - SRSF protein kinase 1 Gene

中文名称：SRSF 蛋白激酶 1

种属: Homo sapiens

同用名: SFRSK1

基因 ID: 6732 | 基因类型: protein coding

关于 SRPK1

Cytogenetic location: 6p21.31 Genomic coordinates (GRCh38): 6:35,832,966-35,921,098 (from NCBI)

This gene has 13 transcripts (splice variants), 217 orthologues and 19 paralogues. Broad expression in testis (RPKM 31.4), bone marrow (RPKM 17.2) and 25 other tissues.

功能概要

该基因编码一种丝氨酸/精氨酸蛋白激酶，对剪接因子 SR (富含丝氨酸/精氨酸的结构域) 家族具有特异性。蛋白质定位于细胞核和细胞质。它被认为通过调节剪接因子的细胞内定位在调节组成型剪接和选择性剪接方面发挥作用。该基因的可变剪接导致多个转录变体。已针对该基因描述了其他可变剪接的转录变体，但尚未确定其全长性质。[RefSeq 提供，2010 年 7 月]

This gene encodes a serine/arginine protein kinase specific for the SR (serine/arginine-rich domain) family of splicing factors. The protein localizes to the nucleus and the cytoplasm. It is thought to play a role in regulation of both constitutive and alternative splicing by regulating intracellular localization of splicing factors. Alternative splicing of this gene results in multiple transcript variants. Additional alternatively spliced transcript variants have been described for this gene, but their full length nature have not been determined.[provided by RefSeq, Jul 2010]

SRPK1 基因产物(1)

mRNA	Protein	Name
NM_003137.5	NP_003128.3	SRSF protein kinase 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables ATP binding	IDA IDA: 通过直接分析推断	11509566	GOA
enables magnesium ion binding	IDA IDA: 通过直接分析推断	11509566	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	9237760	GOA
enables protein serine/threonine kinase activity	IDA IDA: 通过直接分析推断	9237760	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in chromosome segregation	IDA IDA: 通过直接分析推断	15034300	GOA
involved in intracellular signal transduction	IDA IDA: 通过直接分析推断	11509566	GOA
involved in negative regulation of viral genome replication	IDA IDA: 通过直接分析推断	12417631	GOA
involved in positive regulation of viral genome replication	IDA IDA: 通过直接分析推断	20498328	GOA
involved in protein phosphorylation	IDA IDA: 通过直接分析推断	9237760	GOA
involved in regulation of mRNA processing	IDA IDA: 通过直接分析推断	8208298	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in chromatin	IDA IDA: 通过直接分析推断	28076779	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	11509566	GOA
located in nuclear speck	IDA IDA: 通过直接分析推断	28076779	GOA
located in nucleoplasm	IDA IDA: 通过直接分析推断	28076779	GOA
located in nucleus	IDA IDA: 通过直接分析推断	11509566	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SRPK1 蛋白结构

Pkinase

0
200
400
600
655 a.a.

蛋白主名

其他名称

SRSF protein kinase 1

SFRS protein kinase 1

SRPK1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	SRPK1	Q96SB4	SREK1	Homo sapiens	Q8WXA9	Pull Down	32707033
种属内	SRPK1	Q96SB4	USP39	Homo sapiens	Q53GS9	Pull Down	32707033
种属内	SRPK1	Q96SB4	USP39	Homo sapiens	Q53GS9	Protein Kinase Assay	23602568
种属内	SRPK1	Q96SB4	SNRNP70	Homo sapiens	P08621	Pull Down	32707033
种属内	SRPK1	Q96SB4	SNRNP70	Homo sapiens	P08621	Protein Kinase Assay	23602568
种属间	SRPK1	Q96SB4	N	SARS-CoV-2	P0DTC9	Protein Kinase Assay	33247108
种属内	SRPK1	Q96SB4	YTHDC1	Homo sapiens	Q96MU7	Anti Tag CoIP	23602568
种属内	SRPK1	Q96SB4	YTHDC1	Homo sapiens	Q96MU7	TAP	23602568
种属内	SRPK1	Q96SB4	LUC7L2	Homo sapiens	Q9Y383	Protein Kinase Assay	23602568
种属内	SRPK1	Q96SB4	LUC7L2	Homo sapiens	Q9Y383	Pull Down	32707033
种属内	SRPK1	Q96SB4	LUC7L2	Homo sapiens	Q9Y383	TAP	23602568
种属内	SRPK1	Q96SB4	TP53	Homo sapiens	P04637	Pull Down	21130767
种属内	SRPK1	Q96SB4	SRSF3	Homo sapiens	P84103	Protein Kinase Assay	23602568
种属内	SRPK1	Q96SB4	SNRPD3	Homo sapiens	P62318	Crosslink	30021884
种属内	SRPK1	Q96SB4	RBM39	Homo sapiens	Q14498	TAP	23602568
种属内	SRPK1	Q96SB4	RBM39	Homo sapiens	Q14498	Pull Down	32707033
种属内	SRPK1	Q96SB4	RNPS1	Homo sapiens	Q15287	Pull Down	32707033
种属内	SRPK1	Q96SB4	RNPS1	Homo sapiens	Q15287	BiFC	23602568
种属内	SRPK1	Q96SB4	SRSF7	Homo sapiens	Q16629	TAP	23602568
种属内	SRPK1	Q96SB4	SRSF1	Homo sapiens	Q07955	Pull Down	10196197
种属内	SRPK1	Q96SB4	RBM8A	Homo sapiens	Q9Y5S9	Protein Kinase Assay	23602568
种属内	SRPK1	Q96SB4	RBM8A	Homo sapiens	Q9Y5S9	TAP	23602568
种属内	SRPK1	Q96SB4	LUC7L	Homo sapiens	Q9NQ29	TAP	23602568
种属内	SRPK1	Q96SB4	DGCR8	Homo sapiens	Q8WYQ5	TAP	23602568
种属内	SRPK1	Q96SB4	U2AF1	Homo sapiens	Q01081	TAP	23602568
种属内	SRPK1	Q96SB4	SRSF8	Homo sapiens	Q9BRL6	TAP	23602568
种属内	SRPK1	Q96SB4	SRPK3	Homo sapiens	Q9UPE1	Protein Kinase Assay	23602568
种属内	SRPK1	Q96SB4	SRPK3	Homo sapiens	Q9UPE1	TAP	23602568
种属内	SRPK1	Q96SB4	ZRSR2	Homo sapiens	Q15696	Protein Kinase Assay	23602568
种属内	SRPK1	Q96SB4	PTK2	Homo sapiens	Q05397	Protein Kinase Assay	23602568
种属内	SRPK1	Q96SB4	PRPF38A	Homo sapiens	Q8NAV1	Pull Down	32707033
种属内	SRPK1	Q96SB4	PRPF38A	Homo sapiens	Q8NAV1	Y2H	22365833
种属间	SRPK1	Q96SB4	a7y3z3_hpv16	Human papillomavirus	A7Y3Z3	CoIP	17360743
种属间	SRPK1	Q96SB4	a7y3z3_hpv16	Human papillomavirus	A7Y3Z3	Pull Down	17360743
种属间	SRPK1	Q96SB4	a7y3z3_hpv16	Human papillomavirus	A7Y3Z3	Fluorescence	17360743
种属内	SRPK1	Q96SB4	KRR1	Homo sapiens	Q13601	Protein Kinase Assay	23602568
种属内	SRPK1	Q96SB4	KRR1	Homo sapiens	Q13601	Pull Down	32707033
种属内	SRPK1	Q96SB4	SRSF6	Homo sapiens	Q13247	Protein Kinase Assay	23602568
种属间	SRPK1	Q96SB4	Safb	Rattus norvegicus	O88453	Pull Down	11509566

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Denys-Drash Syndrome

Drash Syndrome	DDS
Nephropathy, Wilms Tumor, And Genital Anomalies	Wilms Tumor And Pseudohermaphroditism
Wilms Tumor And Pseudo- Or True Hermaphroditism	Nephropathy Associated With Male Pseudohermaphroditism And Wilms' Tumor
Pseudohermaphroditism, Nephron Disorder And Wilms' Tumor	Wilms Tumor-Dsd Syndrome
Wilms Tumor-Disorder Of Sex Development Syndrome

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-117661	SPHINX31	Inhibitor	99.13%	否
HY-13949	SRPIN340	Inhibitor	99.97%	否
HY-116856	SRPKIN-1	Inhibitor	98.02%	否
HY-148518	MSC-1186	Inhibitor	99.42%	否
HY-114653	SRPIN803	Inhibitor	99.17%	否
HY-132126	SPHINX	Inhibitor	99.87%	否
HY-113831	CLK1/2-IN-3	Inhibitor	/	否
HY-160586	Srpk1-IN-1	Inhibitor	/	否
HY-160587	Antiangiogenic agent 5	Inhibitor	/	否
HY-RS13777	SRPK1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	SRPK1	RGD	RGD:1308272
Bos taurus	SRPK1	VGNC	VGNC:54238
Canis familiaris	SRPK1	VGNC	VGNC:54365
Felis catus	SRPK1	VGNC	VGNC:65687
Macaca mulatta	SRPK1	VGNC	VGNC:103870
Mus musculus	SRPK1	MGD	MGI:106908

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2025 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4