RNPS1 - RNA binding protein with serine rich domain 1 Gene

中文名称：具有富丝氨酸结构域 1 的 RNA 结合蛋白

种属: Homo sapiens

同用名: E5.1

关于 RNPS1

功能概要

该基因编码的蛋白质是参与 mRNA 核输出和 mRNA 监视的剪接后多蛋白复合物的一部分。 mRNA 监测检测具有截短开放阅读框的输出 mRNA，并启动无义介导的 mRNA 衰变 (NMD) 。当翻译在最后一个外显子-外显子连接处的上游结束时，这会触发 NMD 降解含有过早终止密码子的 mRNA。这种蛋白质与 mRNA 结合并在核输出后保持结合，充当核质穿梭蛋白。这种蛋白质含有许多丝氨酸残基。已发现该基因编码不同亚型的几种转录变体。[RefSeq 提供，2013 年 11 月]

This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. This protein contains many serine residues. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]