SRSF7 - serine and arginine rich splicing factor 7 Gene

中文名称：富丝氨酸和精氨酸的剪接因子 7

种属: Homo sapiens

同用名: 9G8; AAG3; SFRS7

基因 ID: 6432 | 基因类型: protein coding

关于 SRSF7

Cytogenetic location: 2p22.1 Genomic coordinates (GRCh38): 2:38,743,599-38,751,494 (from NCBI)

This gene has 12 transcripts (splice variants), 232 orthologues and 8 paralogues. Ubiquitous expression in bone marrow (RPKM 57.8), lymph node (RPKM 43.5) and 25 other tissues.

功能概要

由该基因编码的蛋白质是富含丝氨酸/精氨酸 (SR) 的 pre-mRNA 剪接因子家族的成员，它构成了剪接体的一部分。这些因子中的每一个都包含一个用于结合 RNA 的 N 端 RNA 识别基序 (RRM) 和一个用于结合其他蛋白质的 C 端 RS 结构域。 RS 结构域富含丝氨酸和精氨酸残基，可促进不同 SR 剪接因子之间的相互作用。除了对 mRNA 剪接至关重要外，SR 蛋白还显示参与 mRNA 从细胞核输出和翻译。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供，2018 年 5 月]

The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an N-terminal RNA recognition motif (RRM) for binding RNA and a C-terminal RS domain for binding Other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2018]

SRSF7 基因产物(3)

mRNA	Protein	Name
NM_001031684.3	NP_001026854.1	serine/arginine-rich splicing factor 7 isoform 1
NM_001195446.2	NP_001182375.1	serine/arginine-rich splicing factor 7 isoform 2
NM_001363802.1	NP_001350731.1	serine/arginine-rich splicing factor 7 isoform 3

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	10749975	GOA
enables protein domain specific binding	IPI IPI: 通过物理相互作用推断	10749975	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in RNA splicing	IDA IDA: 通过直接分析推断	8013463	GOA
involved in negative regulation of mRNA splicing, via spliceosome	IDA IDA: 通过直接分析推断	15009664	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SRSF7 蛋白结构

RRM_1

0
100
200
238 a.a.

蛋白主名

其他名称

serine/arginine-rich splicing factor 7

SR splicing factor 7

SRSF7 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	SRSF7	Q16629	RBBP6	Homo sapiens	Q7Z6E9	Anti Tag CoIP	33961781
Intra	SRSF7	Q16629	RBBP6	Homo sapiens	Q7Z6E9	Anti Tag CoIP	18624398
Intra	SRSF7	Q16629	LUC7L2	Homo sapiens	Q9Y383	Y2H Array	31515488
Intra	SRSF7	Q16629	LUC7L2	Homo sapiens	Q9Y383	Y2H Prey Pooling	25416956
Intra	SRSF7	Q16629	LUC7L2	Homo sapiens	Q9Y383	Validated Y2H	25416956
Intra	SRSF7	Q16629	LUC7L2	Homo sapiens	Q9Y383	Validated Y2H	32296183
Intra	SRSF7	Q16629	LUC7L2	Homo sapiens	Q9Y383	Y2H Array	25416956
Intra	SRSF7	Q16629	RNPS1	Homo sapiens	Q15287	Anti Tag CoIP	33961781
Intra	SRSF7	Q16629	NXF1	Homo sapiens	Q9UBU9	Pull Down	17036044
Intra	SRSF7	Q16629	NXF1	Homo sapiens	Q9UBU9	CoIP	15184380
Intra	SRSF7	Q16629	SRPK1	Homo sapiens	Q96SB4	Anti Tag CoIP	33961781
Intra	SRSF7	Q16629	SRPK1	Homo sapiens	Q96SB4	Protein Kinase Assay	23602568
Intra	SRSF7	Q16629	SRPK2	Homo sapiens	P78362	Anti Tag CoIP	33961781
Intra	SRSF7	Q16629	LUC7L	Homo sapiens	Q9NQ29-3	Validated Y2H	32296183
Intra	SRSF7	Q16629	PRPF38A	Homo sapiens	Q8NAV1	Validated Y2H	32296183
Intra	SRSF7	Q16629	SDCBP	Homo sapiens	O00560	Y2H Prey Pooling	25416956
Intra	SRSF7	Q16629	SDCBP	Homo sapiens	O00560	Y2H Array	25416956
Cross	SRSF7	Q16629	Srek1	Rattus norvegicus	Q9JKL7	Pull Down	14559993

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Allergic Bronchopulmonary Aspergillosis

Aspergillosis, Allergic Bronchopulmonary	Abpa
Allergic Bronchopulmonary Mycosis	Hinson-Pepys Disease
Pulmonary Aspergillus Disease	Allergic Aspergillosis
Aspergillosis Allergic Bronchopulmonary

Frontotemporal Dementia

Pallidopontonigral Degeneration	Frontotemporal Lobar Degeneration
Semantic Dementia	FTD
Frontotemporal Lobe Dementia	Multiple System Tauopathy With Presenile Dementia
Dementia, Frontotemporal	Frontotemporal Dementia With Parkinsonism
Mstd	Frontotemporal Lobar Degeneration With Tau Inclusions
Ftld With Tau Inclusions	Dementia, Frontotemporal, With Parkinsonism
Fldem	Ftdp17
Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex	Ddpac
Wilhelmsen-Lynch Disease	Wld
Ppnd	Dementia, Frontotemporal, With Or Without Parkinsonism
Semantic Primary Progressive Aphasia	Semantic Variant Ppa
Wilhemsen-Lynch Disease	Frontotemporal Dementia-Amyotrophic Lateral Sclerosis
Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17	Ftd-Als
Ftld	Pick Complex
Pick Disease Of The Brain	Frontotemporal Dementia With Parkinsonism-17
Grn-Related Frontotemporal Dementia	Frontotemporal Dementia With Motor Neuron Disease
Dementia In Fronto-Temporal Lobar Degeneration	Ftd - [Frontotemporal Dementia]
Temple Dementia	Frontal Lobe Dementia

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS13798	SRSF7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	SRSF7	VGNC	VGNC:77822
Felis catus	SRSF7	VGNC	VGNC:81226
Canis familiaris	SRSF7	VGNC	VGNC:46821
Rattus norvegicus	SRSF7	RGD	RGD:1307425
Mus musculus	SRSF7	MGD	MGI:1926232
Bos taurus	SRSF7	VGNC	VGNC:35303

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