SRPK2 - SRSF protein kinase 2 Gene

中文名称：SRSF 蛋白激酶 2

种属: Homo sapiens

同用名: SFRSK2

基因 ID: 6733 | 基因类型: protein coding

关于 SRPK2

Cytogenetic location: 7q22.3 Genomic coordinates (GRCh38): 7:105,114,740-105,399,357 (from NCBI)

This gene has 15 transcripts (splice variants), 236 orthologues and 19 paralogues. Broad expression in testis (RPKM 31.3), brain (RPKM 21.9) and 24 other tissues.

功能概要

启用 ATP 绑定活动；镁离子结合活性；和蛋白丝氨酸/苏氨酸激酶活性。参与多个过程，包括核酸代谢过程；肽基丝氨酸磷酸化；和病毒基因组复制的调控。位于染色质；胞质溶胶；和核腔。 [由基因组资源联盟提供，2022 年 4 月]

Enables ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Involved in several processes, including nucleic acid metabolic process; peptidyl-serine phosphorylation; and regulation of viral genome replication. Located in chromatin; cytosol; and nuclear lumen. [provided by Alliance of Genome Resources, Apr 2022]

SRPK2 基因产物(12)

mRNA	Protein	Name
NM_001278273.2	NP_001265202.1	SRSF protein kinase 2 isoform b precursor
NM_001350738.2	NP_001337667.1	SRSF protein kinase 2 isoform b
NM_001350739.2	NP_001337668.1	SRSF protein kinase 2 isoform c
NM_001350740.2	NP_001337669.1	SRSF protein kinase 2 isoform d
NM_001350741.2	NP_001337670.1	SRSF protein kinase 2 isoform e
NM_001350742.2	NP_001337671.1	SRSF protein kinase 2 isoform f
NM_001350743.2	NP_001337672.1	SRSF protein kinase 2 isoform g
NM_001350744.2	NP_001337673.1	SRSF protein kinase 2 isoform g
NM_001350745.2	NP_001337674.1	SRSF protein kinase 2 isoform h
NM_001350746.2	NP_001337675.1	SRSF protein kinase 2 isoform i
NM_182691.3	NP_872633.1	SRSF protein kinase 2 isoform b precursor
NM_182692.3	NP_872634.1	SRSF protein kinase 2 isoform a

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables ATP binding	IDA IDA: 通过直接分析推断	9472028	GOA
enables magnesium ion binding	IDA IDA: 通过直接分析推断	9472028	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	16189514	GOA
enables protein serine/threonine kinase activity	IDA IDA: 通过直接分析推断	9472028	GOA
enables protein serine/threonine kinase activity	IGI IGI: 通过遗传相互作用推断	26167880	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in R-loop processing	IDA IDA: 通过直接分析推断	28076779	GOA
involved in RNA splicing	IDA IDA: 通过直接分析推断	9472028	GOA
involved in intracellular signal transduction	IDA IDA: 通过直接分析推断	9472028	GOA
involved in negative regulation of viral genome replication	IDA IDA: 通过直接分析推断	12417631	GOA
involved in peptidyl-serine phosphorylation	IGI IGI: 通过遗传相互作用推断	26167880	GOA
involved in positive regulation of cell population proliferation	IDA IDA: 通过直接分析推断	18559500	GOA
involved in positive regulation of viral genome replication	IDA IDA: 通过直接分析推断	20498328	GOA
involved in protein phosphorylation	IDA IDA: 通过直接分析推断	9472028	GOA
involved in spliceosomal complex assembly	IDA IDA: 通过直接分析推断	9472028	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in chromatin	IDA IDA: 通过直接分析推断	28076779	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	9472028	GOA
located in nuclear speck	IDA IDA: 通过直接分析推断	28076779	GOA
located in nucleoplasm	IDA IDA: 通过直接分析推断	28076779	GOA
located in nucleus	IDA IDA: 通过直接分析推断	9472028	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SRPK2 蛋白结构

Pkinase

0
200
400
600
688 a.a.

蛋白主名

其他名称

SRSF protein kinase 2

SFRS protein kinase 2

SRPK2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	SRPK2	P78362	rnps1	Homo sapiens	D3DU92	Validated Y2H	25416956
种属内	SRPK2	P78362	rnps1	Homo sapiens	D3DU92	Y2H Prey Pooling	25416956
种属内	SRPK2	P78362	U2AF1	Homo sapiens	Q01081-2	Validated Y2H	25416956
种属内	SRPK2	P78362	LUZP4	Homo sapiens	Q9P127	Validated Y2H	25416956
种属内	SRPK2	P78362	RIMS1	Homo sapiens	Q86UR5	Anti Bait CoIP	37207277
种属内	SRPK2	P78362	SREK1	Homo sapiens	Q8WXA9	Pull Down	32707033
种属内	SRPK2	P78362	SREK1	Homo sapiens	Q8WXA9	Anti Tag CoIP	33961781
种属内	SRPK2	P78362	SNRNP70	Homo sapiens	P08621	Y2H	22365833
种属内	SRPK2	P78362	SNRNP70	Homo sapiens	P08621	Pull Down	32707033
种属内	SRPK2	P78362	SNRNP70	Homo sapiens	P08621	Protein Kinase Assay	23602568
种属内	SRPK2	P78362	SNRNP70	Homo sapiens	P08621	TAP	23602568
种属内	SRPK2	P78362	SRRM1	Homo sapiens	Q8IYB3	Pull Down	32707033
种属内	SRPK2	P78362	SRRM1	Homo sapiens	Q8IYB3	BiFC	23602568
种属内	SRPK2	P78362	SRRM1	Homo sapiens	Q8IYB3	Anti Tag CoIP	33961781
种属内	SRPK2	P78362	SRRM1	Homo sapiens	Q8IYB3	TAP	23602568
种属内	SRPK2	P78362	SRSF8	Homo sapiens	Q9BRL6-2	Validated Y2H	32296183
种属内	SRPK2	P78362	FXR1	Homo sapiens	P51114-2	Y2H Prey Pooling	32296183
种属内	SRPK2	P78362	FXR1	Homo sapiens	P51114-2	Y2H Array	32296183
种属内	SRPK2	P78362	U2AF2	Homo sapiens	P26368-2	Y2H Array	32296183
种属内	SRPK2	P78362	U2AF2	Homo sapiens	P26368-2	Y2H Prey Pooling	32296183
种属内	SRPK2	P78362	HCN1	Homo sapiens	O60741	Anti Bait CoIP	37207277
种属内	SRPK2	P78362	SRSF11	Homo sapiens	Q05519-2	Validated Y2H	32296183
种属内	SRPK2	P78362	SRSF11	Homo sapiens	Q05519-2	Y2H Array	32296183
种属内	SRPK2	P78362	SRSF11	Homo sapiens	Q05519-2	Y2H Prey Pooling	32296183
种属内	SRPK2	P78362	ZSCAN12	Homo sapiens	O43309	Y2H Prey Pooling	32296183
种属内	SRPK2	P78362	ZSCAN12	Homo sapiens	O43309	Y2H Array	32296183
种属内	SRPK2	P78362	PRR20D	Homo sapiens	P86480	Y2H Prey Pooling	32296183
种属内	SRPK2	P78362	PRR20D	Homo sapiens	P86480	Y2H Array	32296183
种属内	SRPK2	P78362	PRR20D	Homo sapiens	P86480	Validated Y2H	32296183
种属内	SRPK2	P78362	SNRNP27	Homo sapiens	Q8WVK2	Y2H	22365833
种属内	SRPK2	P78362	DDX46	Homo sapiens	Q7L014	Pull Down	32707033
种属内	SRPK2	P78362	DDX46	Homo sapiens	Q7L014	TAP	23602568
种属内	SRPK2	P78362	DDX46	Homo sapiens	Q7L014	Anti Tag CoIP	33961781
种属内	SRPK2	P78362	ARL6IP4	Homo sapiens	Q66PJ3	Pull Down	32707033
种属内	SRPK2	P78362	ARL6IP4	Homo sapiens	Q66PJ3	Protein Kinase Assay	23602568
种属内	SRPK2	P78362	TRA2A	Homo sapiens	Q13595	Protein Kinase Assay	23602568
种属内	SRPK2	P78362	TRA2A	Homo sapiens	Q13595	Pull Down	32707033
种属内	SRPK2	P78362	NOM1	Homo sapiens	Q5C9Z4	Y2H Array	32296183
种属内	SRPK2	P78362	NOM1	Homo sapiens	Q5C9Z4	Y2H Prey Pooling	32296183
种属内	SRPK2	P78362	NOM1	Homo sapiens	Q5C9Z4	Validated Y2H	32296183
种属内	SRPK2	P78362	ARGLU1	Homo sapiens	Q9NWB6	Y2H	22365833
种属内	SRPK2	P78362	ARGLU1	Homo sapiens	Q9NWB6	Anti Tag CoIP	33961781
种属内	SRPK2	P78362	YTHDC1	Homo sapiens	Q96MU7	Anti Tag CoIP	33961781
种属内	SRPK2	P78362	YTHDC1	Homo sapiens	Q96MU7	TAP	23602568
种属内	SRPK2	P78362	YTHDC1	Homo sapiens	Q96MU7	BiFC	23602568
种属内	SRPK2	P78362	YTHDC1	Homo sapiens	Q96MU7	Pull Down	32707033
种属内	SRPK2	P78362	CHTOP	Homo sapiens	Q9Y3Y2	Protein Kinase Assay	23602568
种属内	SRPK2	P78362	CHTOP	Homo sapiens	Q9Y3Y2	Pull Down	32707033
种属内	SRPK2	P78362	LUC7L2	Homo sapiens	Q9Y383	Pull Down	32707033
种属内	SRPK2	P78362	LUC7L2	Homo sapiens	Q9Y383	TAP	23602568
种属内	SRPK2	P78362	SRSF10	Homo sapiens	O75494	Pull Down	32707033
种属内	SRPK2	P78362	SRSF10	Homo sapiens	O75494	Anti Tag CoIP	33961781
种属内	SRPK2	P78362	DDX21	Homo sapiens	Q9NR30	TAP	23602568
种属内	SRPK2	P78362	HNRNPC	Homo sapiens	P07910	TAP	23602568
种属内	SRPK2	P78362	RBM39	Homo sapiens	Q14498	Anti Tag CoIP	33961781
种属内	SRPK2	P78362	RBM39	Homo sapiens	Q14498	Validated Y2H	25416956
种属内	SRPK2	P78362	RBM39	Homo sapiens	Q14498	Protein Kinase Assay	23602568
种属内	SRPK2	P78362	RBM39	Homo sapiens	Q14498	Pull Down	32707033
种属内	SRPK2	P78362	RBM39	Homo sapiens	Q14498	Y2H Prey Pooling	25416956
种属内	SRPK2	P78362	RBM39	Homo sapiens	Q14498	Y2H Array	25416956
种属内	SRPK2	P78362	RBM39	Homo sapiens	Q14498	TAP	23602568
种属内	SRPK2	P78362	RNPS1	Homo sapiens	Q15287	Y2H	22365833
种属内	SRPK2	P78362	RNPS1	Homo sapiens	Q15287	Validated Y2H	32296183
种属内	SRPK2	P78362	RNPS1	Homo sapiens	Q15287	Pull Down	32707033
种属内	SRPK2	P78362	TCOF1	Homo sapiens	Q13428	Pull Down	32707033
种属内	SRPK2	P78362	ACIN1	Homo sapiens	Q9UKV3	Anti Tag CoIP	33961781
种属内	SRPK2	P78362	ACIN1	Homo sapiens	Q9UKV3	TAP	23602568
种属内	SRPK2	P78362	ACIN1	Homo sapiens	Q9UKV3	Y2H	22365833
种属内	SRPK2	P78362	SRSF7	Homo sapiens	Q16629	Protein Kinase Assay	23602568
种属内	SRPK2	P78362	SRSF7	Homo sapiens	Q16629	TAP	23602568
种属内	SRPK2	P78362	RBM8A	Homo sapiens	Q9Y5S9	TAP	23602568
种属内	SRPK2	P78362	LUC7L	Homo sapiens	Q9NQ29	Protein Kinase Assay	23602568
种属内	SRPK2	P78362	LUC7L	Homo sapiens	Q9NQ29	Pull Down	32707033
种属内	SRPK2	P78362	LUC7L	Homo sapiens	Q9NQ29	TAP	23602568
种属内	SRPK2	P78362	SRSF12	Homo sapiens	Q8WXF0	Anti Tag CoIP	33961781
种属内	SRPK2	P78362	SRSF12	Homo sapiens	Q8WXF0	Protein Kinase Assay	23602568
种属内	SRPK2	P78362	NSRP1	Homo sapiens	Q9H0G5	Anti Tag CoIP	35271311
种属内	SRPK2	P78362	NSRP1	Homo sapiens	Q9H0G5	Protein Kinase Assay	23602568
种属内	SRPK2	P78362	U2AF1	Homo sapiens	Q01081	Anti Tag CoIP	23602568
种属内	SRPK2	P78362	U2AF1	Homo sapiens	Q01081	TAP	23602568
种属内	SRPK2	P78362	U2AF1	Homo sapiens	Q01081	Y2H	22365833
种属内	SRPK2	P78362	U2AF1	Homo sapiens	Q01081	Y2H Array	25416956
种属内	SRPK2	P78362	SRSF8	Homo sapiens	Q9BRL6	Anti Tag CoIP	33961781
种属内	SRPK2	P78362	SRSF8	Homo sapiens	Q9BRL6	Protein Kinase Assay	23602568
种属内	SRPK2	P78362	SRSF8	Homo sapiens	Q9BRL6	TAP	23602568
种属内	SRPK2	P78362	ZRSR2	Homo sapiens	Q15696	Validated Y2H	32296183
种属内	SRPK2	P78362	ZRSR2	Homo sapiens	Q15696	Y2H Array	25416956
种属内	SRPK2	P78362	ZRSR2	Homo sapiens	Q15696	Validated Y2H	25416956
种属内	SRPK2	P78362	RSRC1	Homo sapiens	Q96IZ7	Anti Tag CoIP	33961781
种属内	SRPK2	P78362	PRPF38A	Homo sapiens	Q8NAV1	Anti Tag CoIP	33961781
种属内	SRPK2	P78362	PRPF38A	Homo sapiens	Q8NAV1	Y2H Array	25416956
种属内	SRPK2	P78362	PRPF38A	Homo sapiens	Q8NAV1	Pull Down	32707033
种属内	SRPK2	P78362	PRPF38A	Homo sapiens	Q8NAV1	Y2H	22365833
种属内	SRPK2	P78362	PRPF38A	Homo sapiens	Q8NAV1	Protein Kinase Assay	23602568
种属内	SRPK2	P78362	TLE5	Homo sapiens	Q08117	Validated Y2H	25416956
种属内	SRPK2	P78362	TLE5	Homo sapiens	Q08117	Y2H Array	25416956
种属内	SRPK2	P78362	TLE5	Homo sapiens	Q08117	Y2H Prey Pooling	25416956
种属内	SRPK2	P78362	SRSF5	Homo sapiens	Q13243	Pull Down	32707033
种属内	SRPK2	P78362	TRA2B	Homo sapiens	P62995	Protein Kinase Assay	23602568
种属内	SRPK2	P78362	TRA2B	Homo sapiens	P62995	Y2H Array	32296183
种属内	SRPK2	P78362	TRA2B	Homo sapiens	P62995	Pull Down	32707033
种属内	SRPK2	P78362	TRA2B	Homo sapiens	P62995	Y2H Prey Pooling	32296183
种属内	SRPK2	P78362	FXR2	Homo sapiens	P51116	Y2H Array	25416956
种属内	SRPK2	P78362	FXR2	Homo sapiens	P51116	Pull Down	32707033
种属内	SRPK2	P78362	HOXB6	Homo sapiens	P17509	Y2H Array	32296183
种属内	SRPK2	P78362	HOXB6	Homo sapiens	P17509	Y2H Prey Pooling	32296183
种属内	SRPK2	P78362	U2AF2	Homo sapiens	P26368	TAP	23602568
种属内	SRPK2	P78362	U2AF2	Homo sapiens	P26368	BiFC	23602568
种属内	SRPK2	P78362	U2AF2	Homo sapiens	P26368	Pull Down	32707033
种属内	SRPK2	P78362	U2AF2	Homo sapiens	P26368	Y2H Pooling	16189514
种属内	SRPK2	P78362	U2AF2	Homo sapiens	P26368	Anti Tag CoIP	23602568
种属内	SRPK2	P78362	MMTAG2	Homo sapiens	Q9BU76	TAP	23602568
种属内	SRPK2	P78362	MMTAG2	Homo sapiens	Q9BU76	Pull Down	32707033
种属内	SRPK2	P78362	MMTAG2	Homo sapiens	Q9BU76	Protein Kinase Assay	23602568
种属内	SRPK2	P78362	CLK3	Homo sapiens	P49761	Y2H Array	25416956
种属内	SRPK2	P78362	CLK3	Homo sapiens	P49761	Anti Tag CoIP	33961781
种属内	SRPK2	P78362	CLK3	Homo sapiens	P49761	Y2H Prey Pooling	25416956
种属内	SRPK2	P78362	CLK3	Homo sapiens	P49761	Validated Y2H	25416956
种属内	SRPK2	P78362	SNIP1	Homo sapiens	Q8TAD8	Validated Y2H	32296183
种属内	SRPK2	P78362	SNIP1	Homo sapiens	Q8TAD8	Y2H Array	32296183
种属内	SRPK2	P78362	SNIP1	Homo sapiens	Q8TAD8	Y2H Prey Pooling	32296183
种属内	SRPK2	P78362	SNIP1	Homo sapiens	Q8TAD8	Y2H	22365833
种属内	SRPK2	P78362	CLK2	Homo sapiens	P49760	Validated Y2H	25416956
种属内	SRPK2	P78362	ZSCAN9	Homo sapiens	O15535	Y2H Array	32296183
种属内	SRPK2	P78362	ZSCAN9	Homo sapiens	O15535	Y2H Prey Pooling	25416956
种属内	SRPK2	P78362	ZSCAN9	Homo sapiens	O15535	Y2H Prey Pooling	32296183
种属内	SRPK2	P78362	RBM23	Homo sapiens	Q86U06	Protein Kinase Assay	23602568
种属内	SRPK2	P78362	COIL	Homo sapiens	P38432	Y2H Prey Pooling	32296183
种属内	SRPK2	P78362	COIL	Homo sapiens	P38432	Y2H Array	32296183
种属内	SRPK2	P78362	RSRC2	Homo sapiens	Q7L4I2	Anti Tag CoIP	33961781

种属间: 跨种属相互作用 种属内: 同种属相互作用

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-148518	MSC-1186	Inhibitor	99.42%	否
HY-113831	CLK1/2-IN-3	Inhibitor	/	否
HY-RS13778	SRPK2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	SRPK2	MGD	MGI:1201408
Felis catus	SRPK2	VGNC	VGNC:65688
Bos taurus	SRPK2	VGNC	VGNC:35289
Canis familiaris	SRPK2	VGNC	VGNC:46811
Rattus norvegicus	SRPK2	RGD	RGD:1305107
Macaca mulatta	SRPK2	VGNC	VGNC:81764
Others	SRPK2	NCBI

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